Product Detailed Description

liposomal Beta-NAD+ 70% — High Bioavailability Cellular Energy Supplement

Product Overview

Liposomal Beta-NAD+ 70% is a premium-grade dietary supplement ingredient delivering β-nicotinamide adenine dinucleotide in an advanced liposomal delivery system. β-NAD⁺ (CAS 53-84-9), also known as nicotinamide adenine dinucleotide, coenzyme I, or β-NAD, is a pyridine nucleotide with the molecular formula C₂₁H₂₇N₇O₁₄P₂ and a molecular weight of 663.43 g/mol. It consists of two nucleotides joined through their phosphate groups, with one nucleotide containing an adenine nucleobase and the other containing nicotinamide. The compound occurs as a white to off-white crystalline powder that is freely soluble in water, and is the oxidized form of NADH, serving as the primary electron acceptor in the mitochondrial electron transport chain.

NAD⁺ is a vital cofactor that functions as an electron carrier in cellular energy transduction, playing a crucial role in energy production and supplying power for most physiological activities in the human body.It is essential for hundreds of metabolic reactions, including glycolysis, the TCA cycle, and fatty acid β-oxidation. NAD⁺ levels decline with age, with research reporting that NAD⁺ levels drop by roughly 50% between ages 40 and 60.This decline is associated with general aging and chronic disorders, including cognitive decline and sarcopenia.NAD⁺ is a crucial redox cofactor and signaling molecule that regulates cellular metabolism, genome stability, and stress responses.

Why Liposomal Technology?

Conventional oral NAD⁺ presents significant bioavailability and stability challenges. The large molecular weight and complex structure of NAD⁺ make it difficult to penetrate cell membranes, resulting in challenging effective absorption and utilization by the human body.Furthermore, NAD⁺ has poor physicochemical stability and is easily broken down under room temperature and high-temperature conditions, which also limits its application as tablets and capsules.Low bioavailability and stability of NAD⁺ formulations are the main factors limiting its effectiveness as an anti-aging treatment.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Intracellular Delivery and Bioavailability — A liposomal formulation of NAD⁺ (LF-NAD⁺) increased the intracellular NAD⁺ content and cell survival in human aortic endothelial cells compared to control NAD⁺ alone. Clinical data demonstrates that Liposomal NAD⁺ achieves 1.52-fold higher bioavailability compared to conventional forms, with 9 times higher NAD⁺ concentration in the liver.A clinical study is evaluating whether liposomal encapsulation significantly enhances oral bioavailability of NAD⁺ compared to native NAD⁺ in healthy adults.

2. Superior Stability — Liposomal NAD⁺ compositions exhibit enhanced chemical, physical, and/or microbial storage stability at a variety of storage temperatures. The phospholipid bilayer shields NAD⁺ from pH-induced degradation, temperature-induced breakdown, and oxidative stress during storage and gastrointestinal transit.

3. Enhanced Anti-Senescence Properties — LF-NAD⁺ treatment significantly reduced the number of senescent cells in both human aortic endothelial cells and human epidermal keratinocytes. The formulation was associated with reduced expression of p16 in both cell types and a significant reduction in p21 in keratinocytes alone, demonstrating enhanced anti-aging effects on vascular and skin cells.

4. Enhanced Skin Penetration — LF-NAD⁺ increased the skin penetration of the active substance NAD⁺ by 30% compared to the application of NAD⁺ alone, as measured ex vivo in skin explants using infrared spectroscopy.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% β-NAD⁺ in the liposomal formulation, with ≥95% (HPLC) assay available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 1.52-fold higher bioavailability compared to conventional forms, with 9 times higher NAD⁺ concentration in the liver and an average particle size of 29 nm.

• Anti-Senescence Properties — LF-NAD⁺ significantly reduces the number of senescent cells in both endothelial cells and keratinocytes, with reduced expression of p16 and p21 senescence markers.

• Enhanced Skin Penetration — Increases skin penetration of NAD⁺ by 30% compared to free NAD⁺.

• Mitochondrial Function Support — NAD⁺ is required for fatty acid metabolism during β-oxidation, glutaminolysis generating α-ketoglutarate, mitochondrial shuttling of metabolites, and energy production.

• Sirtuin and PARP Activation — NAD⁺ dynamically regulates NAD⁺-dependent enzyme systems, including sirtuins and poly(ADP-ribose) polymerases, supporting DNA repair, epigenetic regulation, and circadian rhythm maintenance.

• Clinically Validated for Friedreich‘s Ataxia — A 12-week randomized controlled trial evaluated NAD⁺ precursor supplementation with nicotinamide riboside in patients with Friedreich’s ataxia, demonstrating safety and tolerability.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated NAD⁺ and its precursors across a range of doses. Weight-based dosing of nicotinamide riboside in a Friedreich‘s ataxia clinical trial was 300 mg for weights of 24–48 kg, 600 mg for weights of 48–72 kg, and 900 mg for weights over 72 kg.A clinical trial in older adults with mild cognitive impairment used 500 mg of nicotinamide riboside twice daily (1,000 mg/day) for 12 weeks.A study in long COVID patients used 2,000 mg of nicotinamide riboside daily for 20 weeks.Commercial liposomal NAD⁺ products typically provide 250–500 mg per capsule or serving, with a recommended intake of 1–2 servings daily. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and intracellular delivery.

Important Safety Information: Liposomal NAD⁺ is generally well tolerated, with reported responses typically mild, temporary, and individual-dependent. Common side effects may include mild nausea, headaches, and fatigue, especially when starting or using higher doses. These usually ease as the body adjusts or when the dose is lowered. Individuals with known hypersensitivity to NAD⁺ or related compounds should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. NAD⁺ may interact with certain medications; consult a healthcare professional if taking prescription drugs.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.