Product Detailed Description

Liposomal vitamin D2 Ergocalciferol 300,000 IU/g — High Bioavailability Vitamin D Supplement

Product Overview

liposomal Vitamin D2 Ergocalciferol 300,000 IU/g is a premium-grade dietary supplement ingredient delivering ergocalciferol in an advanced liposomal delivery system. Ergocalciferol (CAS 50-14-6), also known as vitamin D2, calciferol, or oleovitamin D2, is a fat-soluble secosteroid with the molecular formula C₂₈H₄₄O and a molecular weight of 396.65 g/mol. It is chemically designated as (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol. Ergocalciferol occurs as white or slightly yellowish, odorless crystalline powder or white to almost white crystals, and is practically insoluble in water but freely soluble in ethanol (96%), methanol, and fatty oils. It is sensitive to air, heat, and light, and undergoes reversible isomerization to pre-ergocalciferol in solution depending on temperature and time, with the activity attributed to both compounds.

Ergocalciferol is one of the two major forms of vitamin D, produced by ultraviolet irradiation of ergosterol in plants, fungi, and yeast. It is the primary form of vitamin D used in food fortification and is also available as a pharmaceutical agent for the treatment and prevention of vitamin D deficiency. Vitamin D2 is essential for calcium and phosphorus metabolism, promoting intestinal calcium absorption, bone mineralization, and maintaining normal neuromuscular function. 1 mg of ergocalciferol is equivalent to 40,000 IU of antirachitic activity.

Why Liposomal Technology?

Conventional ergocalciferol presents significant formulation and stability challenges. The compound is sensitive to air, heat, and light, and undergoes reversible isomerization to pre-ergocalciferol in solution. Additionally, as a highly lipophilic molecule, ergocalciferol requires bile salt-dependent micelle formation for intestinal absorption, and its oral bioavailability is influenced by dietary fat intake and individual gastrointestinal conditions.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability and Photoprotection — The phospholipid bilayer shields ergocalciferol from oxygen, heat, and light-induced degradation, preserving its intact molecular structure and biological activity during storage and gastrointestinal transit. liposomes have shown significant promise for encapsulating lipophilic bioactives and improving their stability and bioaccessibility.

2. Enhanced Bioaccessibility — Vitamin D2 can be incorporated into phospholipid liposomes at concentrations up to approximately 35 wt.%, providing a stable and homogeneous formulation that enhances the dispersion and absorption of this fat-soluble vitamin in aqueous environments. Liposomal delivery systems have been demonstrated to significantly improve the bioaccessibility of lipophilic vitamins.

3. Enhanced Cellular Uptake and Targeted Delivery — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism complements the physiological absorption pathways utilized by free ergocalciferol, supporting enhanced systemic absorption and tissue distribution.

4. Water-Dispersible and Clean-Label Compatible — The liposomal powder disperses readily in aqueous systems, making it suitable for functional beverages and liquid formulations. The phospholipid carrier is plant-derived and non-GMO, supporting clean-label positioning.

Product Specifications

Key Features

• High Purity — Standardized to 300,000 IU/g of vitamin D2 activity, with assay of 97.0%–103.0% (HPLC) available and higher potencies up to 40,000,000 IU/g available upon request.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances stability, bioaccessibility, and cellular uptake of ergocalciferol, with incorporation levels up to approximately 35 wt.% in liposomal formulations.

• Essential Bone Health Support — Vitamin D2 maintains normal calcium and phosphorus metabolism, promoting intestinal calcium absorption and bone mineralization to support musculoskeletal health.

• Immune Function Support — Vitamin D2 is essential for immune system regulation and supports the body's natural defense mechanisms.

• Clinically Established for Deficiency Treatment — Ergocalciferol is indicated for the prophylaxis and treatment of vitamin D deficiency, including rickets, osteomalacia, and hypocalcemia.

• Plant-Derived and Vegan-Friendly — Vitamin D2 is produced by UV irradiation of ergosterol from yeast, making it suitable for vegan and vegetarian formulations.

• Food Fortification Ready — Ergocalciferol is the primary form of vitamin D used in food fortification, including beverages, dairy products, cereals, and infant formula.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems compared to crystalline ergocalciferol; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Prophylaxis: For adults, the recommended prophylactic dose is 400–1,000 IU/day. For children and adults with reduced vitamin D availability (obesity, pigmented skin, lack of sun exposure) or reduced intake (vegan diet), 1,000–2,000 IU/day may be appropriate.

Deficiency Treatment: For the treatment of vitamin D deficiency (rickets, osteomalacia, neonatal hypocalcemia), the recommended dose is 2,000–4,000 IU/day for 3–6 months. Alternatively, high-dose protocols may include 50,000 IU weekly for 8 weeks or a single dose of 200,000 IU.

Pregnancy and Lactation: For the treatment of deficiency in pregnant or breastfeeding women, doses up to 2,000 IU/day (5 drops) or a maximum of 4,000 IU/day (10 drops) are recommended.

Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and protection from degradation.

Important Safety Information: Vitamin D2 is generally well tolerated at recommended doses. The Tolerable Upper Intake Level (UL) for vitamin D is 4,000 IU/day for adults, although higher doses may be used under medical supervision. Excessive intake of vitamin D can cause hypercalcemia, which may result in nausea, vomiting, weakness, and renal complications. Individuals with hypercalcemia, hyperphosphatemia, or severe renal impairment should consult a healthcare professional before use. Pregnant or lactating women and children should consult a healthcare professional before use. Vitamin D2 may interact with certain medications, including thiazide diuretics, cardiac glycosides, and corticosteroids.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.