Product Detailed Description

Liposomal L-citrulline 80% — High Bioavailability Nitric Oxide Support Supplement

Product Overview

liposomal L-Citrulline 80% is a premium-grade dietary supplement ingredient delivering L-citrulline in an advanced liposomal delivery system. L-Citrulline (CAS 372-75-8), also known as (2S)-2-amino-5-(carbamoylamino)pentanoic acid, is a non-proteinogenic α-amino acid with the molecular formula C₆H₁₃N₃O₃ and a molecular weight of 175.19 g/mol . It is a white crystalline powder that is soluble in water and is derived from ornithine through the catabolism of proline, glutamine, and glutamate, or obtained through the arginine-citrulline pathway .

L-Citrulline is a central intermediate in the urea cycle and serves as a precursor to L-arginine, which is subsequently converted to nitric oxide (NO) by endothelial nitric oxide synthase (eNOS). Because L-citrulline is not metabolized by arginase—the enzyme that degrades L-arginine in the liver and intestine—it provides a more efficient route for elevating plasma L-arginine and supporting NO production . NO is a critical signaling molecule that regulates vascular tone, blood flow, and endothelial function.

Why Liposomal Technology?

Conventional L-citrulline presents formulation challenges. As a highly polar amino acid, it competes with other amino acids for transport across the intestinal epithelium. While L-citrulline is more bioavailable than L-arginine, optimizing its delivery can further enhance its therapeutic potential.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Absorption and Bioavailability — Liposomal encapsulation protects L-citrulline from premature metabolism in the gastrointestinal tract and facilitates efficient cellular uptake via lipid-mediated pathways. This delivery mechanism complements the amino acid transport pathways utilized by free L-citrulline.

2. Protection from First-Pass Metabolism — The phospholipid bilayer shields L-citrulline from enzymatic degradation, preserving its intact structure until reaching optimal absorption sites in the small intestine. This is particularly important because L-citrulline‘s primary advantage over L-arginine is its ability to bypass hepatic arginase metabolism.

3. Sustained Release for Balanced Nitric Oxide Support — Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting balanced and prolonged NO production rather than a sharp peak followed by rapid decline. Studies demonstrate that L-citrulline is converted to L-arginine in the kidneys, providing a time-release effect that is more effective than direct L-arginine supplementation .

4. Water-Dispersible Formulation — Liposomal L-citrulline powder offers excellent dispersibility in water, forming a uniform suspension suitable for functional beverages and liquid formulations.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-citrulline, with USP-grade assay of 98.5%–101.0% available .

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects L-citrulline from first-pass metabolism and enhances intestinal absorption through lipid-mediated pathways.

• Superior to L-Arginine — L-Citrulline is not metabolized by arginase, the enzyme that degrades L-arginine in the liver and intestine, making it a more effective precursor for elevating plasma L-arginine and supporting NO production .

• Clinically Studied for Vascular Function — A study in patients with heart failure with preserved ejection fraction (HFpEF) demonstrated that 7-day L-citrulline administration (6 g/day) improved brachial artery endothelium-dependent vasodilation, upper and lower limb microvascular function, and physical capacity .

• Clinically Studied for Erectile Function — A randomized, double-blind, placebo-controlled trial in men with mild erectile dysfunction demonstrated that 1.5 g/day of L-citrulline for 1 month improved Erection Hardness Score from 2.4 to 3.1 .

• Clinically Studied for Metabolic Health — A randomized clinical trial in obese adolescents with MASLD demonstrated that L-citrulline supplementation alone decreased the degree of hepatic steatosis (p = 0.038) .

• Water-Soluble — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated L-citrulline across a range of doses. A pharmacokinetic study in healthy volunteers used single doses of 3–15 g, with peak L-arginine levels occurring approximately 1 hour post-dose and lasting up to 6 hours . A randomized controlled trial in men with mild erectile dysfunction used 1.5 g/day for 1 month . A study in HFpEF patients used 6 g/day (3 g twice daily) for 7 days . A randomized clinical trial in obese adolescents with MASLD used L-citrulline supplementation for 12 weeks . Commercial products typically recommend mixing 1–2 scoops (5–12 g) with any drink daily, with or without food . For exercise performance, 1–2 servings are taken prior to workout .

Important Safety Information: L-Citrulline is generally safe for most healthy adults. Reported side effects are mild and may include upset stomach, diarrhea (at high doses), and mild headache . Caution is advised when taking L-citrulline with blood pressure medication, nitrates, or PDE5 inhibitors due to potential additive effects on blood pressure . Individuals with low blood pressure or heart-related conditions should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.