Liposomal L-Threonine 80% — High Bioavailability Gut Barrier and Immune Support Supplement

Product Overview

liposomal L-Threonine 80% is a premium-grade dietary supplement ingredient delivering L-threonine in an advanced liposomal delivery system. L-Threonine (CAS 72-19-5), also known as (2S,3R)-2-amino-3-hydroxybutanoic acid, is an essential proteinogenic amino acid with the molecular formula C₄H₉NO₃ and a molecular weight of 119.12 g/mol. It occurs as a white crystalline powder or crystalline substance and is freely soluble in water (90 g/L at 20°C), soluble in formic acid, and practically insoluble in ethanol. L-Threonine contains a hydroxyl group in its side chain, classifying it as a polar, uncharged amino acid.

L-Threonine is one of the nine essential amino acids in humans and cannot be synthesized endogenously. It is found in high-protein foods including meat, poultry, fish, dairy products, eggs, and legumes. L-Threonine is particularly important because it is the most abundant amino acid in gastrointestinal mucin, the gel-like protective layer that lines the intestinal epithelium and serves as the first line of defense against bacterial penetration and inflammatory insult. It also serves as a precursor for the biosynthesis of immunoglobulins, which play a critical role in Immune Regulation and host defense.

Why Liposomal Technology?

Conventional L-threonine presents significant formulation challenges. As a large neutral amino acid, it competes with other LNAAs—including leucine, isoleucine, valine, phenylalanine, and tyrosine—for transport across the intestinal epithelium via the L-type amino acid transporter (LAT1). This competition limits the fraction of orally administered L-threonine that reaches systemic circulation and target tissues. Additionally, intestinal inflammation is known to increase gastrointestinal threonine uptake and mucin synthesis, indicating that the demand for threonine can exceed supply under conditions of gut stress.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Absorption and Bioavailability — Liposomal delivery systems encapsulate amino acids in phospholipid-based liposomes, which enhance absorption and bioavailability compared to conventional forms. The phospholipid bilayer shields L-threonine from premature metabolism in the gastrointestinal tract and facilitates efficient cellular uptake via lipid-mediated pathways.

2. Protection from Competitive Transport — Liposomal encapsulation bypasses the competitive LNAA transport pathway by utilizing lipid-mediated absorption mechanisms, ensuring efficient delivery of L-threonine to target cells independent of the LNAA ratio in plasma.

3. Targeted Delivery to Intestinal Tissue — L-Threonine is the most abundant amino acid in gastrointestinal mucin, and its bioavailability directly determines the body’s capacity to maintain adequate mucin synthesis. Liposomal delivery provides targeted delivery of threonine to intestinal tissues, supporting the integrity of the mucosal barrier and the production of protective mucin.

4. Sustained Release and Formulation Stability — Liposomes provide a gradual, sustained release for prolonged efficacy, protecting sensitive ingredients from oxidative degradation and ensuring excellent compatibility with biological systems. Lipoamino acids offer greater formulation stability, making them ideal for use in powders, capsules, liquid sachets, and functional beverages.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-threonine by HPLC, with USP/EP grade assay of 98.5%–101.5% on dried basis available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances absorption and bioavailability, protects from oxidative degradation, and provides sustained release for prolonged efficacy.

• Mucin Synthesis Support — L-Threonine is the most abundant amino acid in gastrointestinal mucin, and its bioavailability directly determines the body‘s capacity to maintain adequate mucin synthesis, the first line of defense of the intestinal barrier.

• Intestinal Immune Modulation — Threonine acts as a nutritional modulator that influences the intestinal immune system via complex signaling networks, particularly the MAPK and TOR signaling pathways. It is important for mucin and immunoglobulin production.

• Clinically Studied for Safety — A randomized double-blind controlled trial established a no-observed-adverse-effect level (NOAEL) for L-threonine of 12 g/day in healthy adult males. Doses of up to 4 g daily have been used safely for up to 12 months.

• Immune Function Support — Threonine attenuates lipopolysaccharide-induced intestinal inflammatory responses and is involved in the synthesis of immunoglobulins, which play the role of immune regulation.

• Water-Dispersible — Freely soluble in water (90 g/L at 20°C); suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and regulatory guidelines commonly recommend varying doses of L-threonine depending on the application. A randomized double-blind controlled trial established a no-observed-adverse-effect level (NOAEL) for L-threonine of 12 g/day in healthy adult males. The requirement for L-threonine in healthy adults is approximately 15 mg/kg body weight per day. In adults (≥18 years), specified doses of 1,000, 1,200, 1,500, 2,000, and 2,400 mg/day of L-threonine in food supplements are unlikely to cause adverse health effects. Doses of up to 4 grams daily have been used safely for up to 12 months. People need about 0.5–1 gram of threonine from their diet daily, and this amount is considered safe. For general gut health and immune support, 500–2,000 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.