Product Detailed Description

liposomal Alpha-Ketoglutarate 70% — High Bioavailability Cellular Energy Supplement

Product Overview

Liposomal Alpha-Ketoglutarate 70% is a premium-grade dietary supplement ingredient delivering alpha-ketoglutarate (AKG) in an advanced liposomal delivery system. AKG (also known as 2-oxoglutarate or 2-oxopentanedioic acid) is a key intermediate in the Krebs cycle (citric acid cycle, TCA cycle), the central metabolic pathway that converts carbohydrates, fats, and proteins into ATP. It is chemically characterized as a dicarboxylic acid with the molecular formula C₅H₆O₅ and a molecular weight of 146.10 g/mol.

AKG serves multiple critical physiological functions. It acts as an energy donor, a precursor of amino acid biosynthesis, and an epigenetic regulator that modulates DNA and histone methylation. Endogenous AKG levels decline significantly with age, and exogenous supplementation has been shown to improve obesity, blood glucose levels, and cardiovascular disease risks associated with metabolic syndrome. In animal models, dietary AKG supplementation extended both lifespan and healthspan, associated with reduced systemic inflammation and increased IL-10 levels. However, native AKG has limited oral bioavailability and is rapidly metabolized in the gastrointestinal tract. Liposomal encapsulation addresses this challenge by protecting AKG during digestive transit and enhancing its delivery to target tissues.

Why Liposomal Technology?

Conventional AKG presents significant formulation challenges. AKG is a highly polar, water-soluble molecule that is rapidly absorbed and metabolized, with limited stability in the gastrointestinal environment. Following oral administration, AKG is primarily taken up by the liver and rapidly converted to other metabolites, limiting its systemic availability and distribution to peripheral tissues.

Liposomal encapsulation provides three critical advantages:

1. Digestive Protection — The phospholipid bilayer shields AKG from gastric acid degradation and premature metabolism during digestive transit, preserving its intact molecular structure until reaching optimal absorption sites in the small intestine. liposomes protect the active α-KG from degradation, mimicking cell membranes to allow endocytosis-like absorption.

2. Enhanced Cellular Uptake and Mitochondrial Delivery — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. By shielding the molecule within a phospholipid bilayer, maximum absorption across the gut lining and direct delivery to the mitochondria—the primary site of AKG's metabolic activity—is achieved.

3. Superior Bioavailability — Conventional pills and powders show limited AKG absorption. The liposomal structure creates a protective layer around nutrients, keeping them away from gastric acid and maintaining optimal bioavailability. This significantly increases bioavailability compared to standard acid-based powders.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% calcium alpha-ketoglutarate, ensuring consistent active content.

• Liposomal Enhancement — Sunflower phospholipid bilayer encapsulation protects AKG from gastric degradation and enhances intestinal absorption through lipid-mediated pathways.

• Mitochondrial Targeting — Liposomal delivery shields AKG and facilitates direct delivery to mitochondria, the primary site of AKG's metabolic activity.

• Krebs Cycle Energy Support — AKG is a key intermediate in the Krebs cycle, supporting efficient ATP production and cellular Energy Metabolism.

• Epigenetic Regulation — AKG serves as a cofactor for dioxygenases that regulate DNA and histone demethylation, playing a central role in epigenetic maintenance.

• Clinically Validated for Biological Age — A clinical study using 1 g/day Ca-AKG with vitamins A and D for an average of 7 months demonstrated an average reduction in biological age of approximately 8 years in healthy individuals aged 40–65.

• Metabolic Health Support — Exogenous AKG supplementation improves obesity, blood glucose levels, and cardiovascular disease risks associated with metabolic syndrome.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated AKG across a range of doses. A clinical study using 1 g/day of calcium alpha-ketoglutarate with vitamins A and D for an average of 7 months demonstrated an average reduction in biological age of approximately 8 years in 42 healthy individuals aged 40–65. An ongoing clinical trial (ABLE) is evaluating sustained-release Ca-AKG at 1 g/day for 6 months in 120 healthy individuals aged 40–60 with higher biological than chronological age. For general metabolic and anti-aging support, 300–600 mg daily is commonly used. In post-menopausal women with osteopenia, 6 g/day of Ca-AKG was evaluated over 6 months, demonstrating a trend toward improvement in bone mineral density. For hemodialysis patients, several clinical trials found Ca-AKG to be safe at doses up to 4.5 g/day. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.