Product Detailed Description

liposomal Glutathione 70% — High Bioavailability Master Antioxidant Supplement

Product Overview

Liposomal Glutathione 70% is a premium-grade dietary supplement ingredient delivering reduced L-glutathione in an advanced liposomal delivery system. Glutathione (γ-L-glutamyl-L-cysteinylglycine; GSH) is a tripeptide synthesized intracellularly from glutamate, cysteine, and glycine, and is the most abundant endogenous antioxidant in human cells. It functions as the body’s primary intracellular antioxidant, neutralizing reactive oxygen species, detoxifying xenobiotics, and maintaining cellular redox homeostasis.

Glutathione concentrations decline significantly with age, oxidative stress, and various disease states. However, conventional oral glutathione supplementation faces a formidable obstacle: the enzyme gamma-glutamyl transferase (GGT), concentrated on the brush border of the small intestine, which rapidly cleaves glutathione molecules before they can reach systemic circulation. This enzymatic barrier results in oral bioavailability estimates as low as 5–25%. Liposomal encapsulation addresses this challenge by protecting glutathione from enzymatic breakdown and facilitating direct cellular uptake.

Why Liposomal Technology?

The liposomal delivery system uses a phospholipid bilayer to fully encapsulate reduced glutathione, shielding it from gastric acid and enzymatic degradation. This bionic vesicle structure is highly compatible with human cell membranes, allowing direct uptake through the intestinal wall.

Liposomal encapsulation provides three critical advantages:

1. Gastric and Enzymatic Protection — The phospholipid bilayer isolates glutathione from digestive juices, gastric acid, and GGT-mediated cleavage, preserving its intact molecular structure until reaching target cells.

2. Enhanced Cellular Uptake — In cellular models using human embryonic kidney 293T cells, liposomal glutathione demonstrated approximately 1.9-fold higher cellular uptake than plain glutathione, peaking at 6 hours (45% vs. 23%). Liposomal glutathione also increased cell proliferation by up to 3-fold over control, superior to plain glutathione, and achieved 100% wound closure at 24 hours versus 59.8% for plain glutathione.

3. Superior Systemic Bioavailability — In a parallel-arm human pharmacokinetic study, twelve healthy subjects received a single oral dose of either liposomal glutathione (LipoDuo™) or plain glutathione (1 g). Liposomal glutathione achieved a maximum plasma concentration of approximately 1,800 ng/ml—6× higher than plain glutathione—with a bimodal absorption pattern and plasma levels maintained above 500 ng/ml at 24 hours.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% reduced glutathione by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves encapsulation efficiency of approximately 75% with particle size of 90–100 nm and zeta potential of −25 to −60 mV.

• 6× Higher Peak Plasma Concentration — Human pharmacokinetic data demonstrates maximum plasma concentration of ~1,800 ng/ml vs. plain glutathione, with levels >500 ng/ml maintained at 24 hours.

• Bimodal Absorption Pattern — Sustained systemic availability through dual-phase absorption, supporting prolonged antioxidant activity.

• Water-Dispersible — Soluble in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Clean-Label Compatible — Fermentation-derived, non-GMO, no artificial additives.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 250–1,000 mg of liposomal glutathione per day. A clinical trial using liposomal GSH (ReadiSorb®) administered 840 mg (two teaspoons) twice daily for a total daily dose of 1,680 mg. Commercial liposomal glutathione products typically recommend daily intake of 50–250 mg, adjustable based on individual needs. For general antioxidant support, 250–500 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.