liposomal Emodin 70% — High Purity Anthraquinone Supplement

Product Overview

Liposomal Emodin 70% is a premium-grade dietary supplement ingredient delivering emodin in an advanced liposomal delivery system. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone derivative found in several traditional medicinal plants, including Rheum palmatum (rhubarb), Polygonum cuspidatum (Japanese knotweed), and Cassia obtusifolia. It is the primary active anthraquinone responsible for the purgative, anti-inflammatory, and hepatoprotective properties attributed to these botanicals.

Emodin has been extensively studied for its broad-spectrum pharmacological activities, including anti-inflammatory, antioxidant, anticancer, antimicrobial, and antifibrotic effects. However, its clinical potential is severely limited by poor water solubility, rapid metabolism, and extremely low oral bioavailability. Liposomal encapsulation addresses these challenges by protecting emodin from degradation and enhancing its delivery to target cells.

Why Liposomal Technology?

Conventional emodin exhibits extremely poor oral bioavailability (approximately 3.2%), with about 56% of the administered dose remaining unabsorbed and excreted into feces as prototype. The molecule undergoes extensive glucuronidation in the liver and intestine, which significantly hinders its absorption and systemic exposure.

Liposomal encapsulation provides three critical advantages:

1. Solubility Enhancement — Emodin is a planar, highly conjugated anthraquinone derivative with poor aqueous solubility (~20 μg/mL). The phospholipid bilayer improves dispersion in aqueous systems and supports uniform formulation.

2. Digestive Protection — liposomes shield emodin from enzymatic degradation and extensive first-pass glucuronidation in the gastrointestinal tract, preserving intact molecular structure until reaching target cells.

3. Enhanced Cellular Uptake and Sustained Release — Emodin-loaded liposomes exhibit significantly enhanced gastrointestinal stability and sustained release properties compared with free emodin, facilitating improved absorption and prolonged circulation time.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% emodin by HPLC, ensuring consistent active content.

• Liposomal Delivery — Phospholipid bilayer encapsulation achieves high encapsulation efficiency (above 80% in optimized formulations) and improves stability, dispersion, and cellular uptake.

• Enhanced Bioavailability — Liposomal encapsulation protects emodin from extensive first-pass metabolism and facilitates improved systemic exposure.

• Sustained Release — Liposomal formulations provide controlled release of emodin, reducing gastrointestinal irritation and maintaining consistent active levels.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated emodin at doses ranging from 25 to 200 mg per day depending on the target application. For general anti-inflammatory and antioxidant support, 50–100 mg daily is commonly used. Liposomal formulations may allow for lower doses due to enhanced bioavailability. Formulators should adjust dosage based on target population, delivery format, and regulatory guidelines.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.