Product Detailed Description

Liposomal dihydromyricetin 70% — High Bioavailability Liver Protection Supplement

Product Overview

liposomal Dihydromyricetin 70% is a premium-grade dietary supplement ingredient delivering dihydromyricetin in an advanced liposomal delivery system. Dihydromyricetin (DHM), also known as ampelopsin, is a naturally occurring flavanonol belonging to the flavonoid subclass of polyphenols. It is chemically characterized by the molecular formula C₁₅H₁₂O₈ and a molecular weight of 320.25 g/mol. DHM is the most abundant bioactive component in vine tea (Ampelopsis grossedentata), a characteristic industrial cash crop in southern China that has been consumed for more than 600 years. Its content in Ampelopsis grossedentata is as high as 35%.

DHM exhibits diverse biological activities, including antioxidant and anti-inflammatory properties, alongside therapeutic potential for neurological and metabolic disorders. Particularly noteworthy are DHM's significant anti-alcohol properties. Research demonstrates that DHM functions as a negative allosteric modulator of GABA_A receptors, effectively reducing alcohol-induced loss of righting reflex, and accelerates alcohol metabolism by enhancing the activities of alcohol metabolic enzymes (ADH and ALDH) while mitigating liver steatosis and injury through activation of AMPK.

Why Liposomal Technology?

Conventional DHM presents fundamental bioavailability challenges. DHM has a remarkably low absolute bioavailability of only 4.02% in rats, primarily due to its poor water solubility, low intestinal permeability, and strong bitter taste. The compound is susceptible to degradation by gastric acid, and its use in medical practice is limited by physicochemical properties and pharmacokinetic characteristics.

Liposomal encapsulation provides three critical advantages:

1. Gastric Protection and Stability Enhancement — The phospholipid bilayer shields DHM from gastric acid degradation and enzymatic metabolism during digestive transit. In the DHM-Lipo-Rg3 formulation, metabolite profiling suggested that liposomal encapsulation protected against enzymatic degradation while enhancing dehydroxylation pathways. The liposomal system significantly enhanced DHM stability and effectively repaired liver damage, maintaining normal liver metabolic functions.

2. Enhanced Cellular Uptake and Superior Bioavailability — In situ single-pass intestinal perfusion demonstrated approximately two-fold enhancement in absorption parameters for DHM-Lipo-Rg3 versus free DHM. Pharmacokinetic studies revealed DHM-Lipo-Rg3 significantly improved bioavailability by 3.1-fold in males and 5.4-fold in females compared to conventional cholesterol-containing liposomes. A separate chitosan-modified DHM liposome (CDL) demonstrated 3.23-fold and 1.92-fold increases in the drug concentration–time curve compared to free DHM and unmodified liposomes, respectively, with 1.49-fold and 1.31-fold increases in Cmax.

3. Targeted Hepatic Delivery and Sustained Release — NIR fluorescence imaging confirmed that DHM liposomes target hepatic macrophages and polarize macrophages into an anti-inflammatory phenotype. The liposomal formulation demonstrated sustained releasing and hepatic targeting, effectively alleviating liver inflammation. Combined with the long-lasting sustained-release characteristic of liposomes, the formulation takes effect continuously for 8–12 hours, helping to quickly restore mental state without the after-effects of hangover or drowsiness.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% dihydromyricetin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves >95% encapsulation efficiency with particle size <90 nm, dramatically improving DHM bioavailability.

• Superior Bioavailability — Liposomal delivery significantly improved bioavailability by 3.1-fold in males and 5.4-fold in females compared to conventional liposomal formulations in pharmacokinetic studies.

• Targeted Liver Protection — Liposomes precisely deliver DHM to liver cells, accelerating alcohol metabolism, reducing acetaldehyde accumulation, and quickly alleviating discomfort such as headache, nausea, and fatigue after drinking.

• Powerful Antioxidant Capacity — The antioxidant capacity of DHM exceeds that of vitamins C and E. Liposomal DHM eliminates free radicals and inhibits lipid peroxidation, effectively repairing fatty liver and drug-induced liver damage.

• Alcohol Metabolism Support — DHM normalizes hepatic alcohol-metabolizing enzymes (ADH and ALDH), significantly increasing alcohol tolerance time and decreasing sober-up time in animal models.

• Gastrointestinal-Liver Axis Synergy — Liposomal DHM moderately regulates intestinal microecology, inhibits harmful bacteria, nourishes beneficial bacteria, and reduces the damage of intestinal toxins to the liver through the “gastrointestinal-liver axis”.

• Water-Dispersible and Taste-Masked — Liposomal encapsulation masks the natural bitterness of DHM, improving palatability for functional food and beverage applications.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 300–900 mg of dihydromyricetin per day. A Phase I, dose-escalation study (NCT05623501) evaluated DHM in healthy volunteers using a purified form from a cGMP-compliant source, with cohort 1 receiving DHM in two doses of 300 mg as liquid suspension, and dose escalation planned to 900 mg. For general liver protection and antioxidant support, 300–600 mg daily is commonly used. For alcohol metabolism support, 300–600 mg taken before or after alcohol consumption is recommended. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability. The continuous sustained-release characteristic of liposomes provides 8–12 hours of action, supporting rapid recovery without hangover after-effects.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.