Product Detailed Description

Liposomal Ferric Pyrophosphate 80% — High Bioavailability Iron Supplement

Product Overview

liposomal Ferric Pyrophosphate 80% is a premium-grade dietary supplement ingredient delivering ferric pyrophosphate (Fe₄(P₂O₇)₃) in an advanced liposomal delivery system. Ferric pyrophosphate is a water-insoluble ferric iron salt in which iron is complexed with pyrophosphate, offering several advantages over conventional ferrous iron salts: higher elemental iron content (24–30%), superior tolerability, no metallic aftertaste, and minimal impact on food color, taste, and texture. This makes it an ideal iron fortificant for food and beverage applications where sensory neutrality is critical.

Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Ferric pyrophosphate is directly absorbed in the intestine, particularly by M cells in the duodenum. However, its water-insoluble nature limits absorption under normal physiological conditions. Liposomal encapsulation addresses this limitation by protecting iron through the gastric environment and releasing it primarily in the small intestine, while also enabling water dispersibility for use in instant beverages and aqueous systems.

Why Liposomal Technology?

Conventional ferric pyrophosphate, while well-tolerated and sensory-neutral, faces absorption challenges due to its poor water solubility. Ionic iron salts such as ferrous sulfate are more soluble but frequently cause gastrointestinal side effects including nausea, cramping, and constipation.

Liposomal encapsulation provides three critical advantages:

1. Gastric Protection — The phospholipid bilayer shields iron from gastric acid and prevents premature reactions with food components, preserving the iron-pyrophosphate complex until reaching optimal absorption sites in the small intestine.

2. Enhanced Dispersibility — The introduction of modified starch allows water-insoluble ferric pyrophosphate to disperse uniformly in cold water, enabling its use in instant beverages and other aqueous systems without sedimentation.

3. Improved Sensory Profile — Liposomal ferric iron offers significantly reduced metallic aftertaste, smooth and neutral mouthfeel, and high compatibility with flavored formulations, overcoming the limitations of traditional iron ingredients.

4. Clinically Validated Efficacy — A prospective randomized controlled trial in 192 children aged 2–12 years with iron-deficiency anemia demonstrated that liposomal iron (SunActive) achieved significantly higher hemoglobin, hematocrit, serum ferritin, and serum iron levels compared to conventional iron polymaltose complex after both 1 month and 6 months of therapy (P<0.001). The liposomal group also exhibited better growth-related anthropometric measurements and improved compliance rates.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% ferric pyrophosphate with elemental iron content ≥80.0 mg/g, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves encapsulation efficiency exceeding 89%, with zeta potential of −39.47 mV and particle size of 1,296 nm for excellent colloidal stability.

• Superior Gastrointestinal Tolerance — Ferric pyrophosphate is generally recognized as safe (GRAS) by the FDA for use as a nutrient supplement in conventional foods and infant formulas. Liposomal encapsulation further minimizes gastric irritation.

• Clinically Validated — Randomized controlled trial in 192 children demonstrated superior efficacy in improving hemoglobin, ferritin, and serum iron levels compared to conventional iron supplements.

• Sensory Neutral — No metallic aftertaste; minimal impact on food color, taste, and texture, making it ideal for food and beverage fortification.

• Water-Dispersible — Disperses uniformly in cold water; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 14–30 mg of elemental iron per day for maintenance in healthy adults and 60–120 mg per day for iron deficiency. A typical dosing regimen of 1–2 capsules daily provides approximately 14–30 mg elemental iron per serving. Ferric pyrophosphate can be taken with meals without the typical reduction in absorption seen with ionic iron forms, offering greater flexibility in dosing. Co-supplementation with vitamin C further enhances absorption. Iron status should be monitored through ferritin and transferrin saturation to guide dosing.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.