Product Detailed Description

Liposomal EDTA iron sodium 80% — High Bioavailability Chelated Iron Supplement

Product Overview

liposomal EDTA Iron Sodium 80% is a premium-grade dietary supplement ingredient delivering ferric sodium EDTA (NaFeEDTA) in an advanced liposomal delivery system. Ferric sodium EDTA is an iron chelate resulting from the deprotonation of all four carboxy groups of ethylenediaminetetraacetic acid and the addition of an iron(III) ion and a sodium ion. It is chemically characterized by the molecular formula C₁₀H₁₂FeN₂NaO₈, with a molecular weight of 367.05 g/mol (anhydrous form).

Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Ferric sodium EDTA is widely used for the treatment of iron deficiency anaemia and as a food fortificant to fulfil nutritional iron requirements. Its chelated structure protects iron from dietary inhibitors such as phytates and tannins, making it an effective iron source even in high-phytate food matrices. Liposomal encapsulation further enhances its performance by protecting the iron-chelate complex during digestive transit and facilitating efficient cellular delivery.

Why Liposomal Technology?

Ferric sodium EDTA already offers superior bioavailability compared to conventional iron salts. The WHO has concluded that sodium iron EDTA is suitable for use as a source of iron for food fortification to fulfil nutritional iron requirements, and is considered safe when used in supervised food fortification programmes. Ferric sodium EDTA has received approval from major regulatory authorities, such as the WHO, FDA, and EFSA, as an iron source with elevated bioavailability and a good safety profile.

Liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the iron-chelate complex during digestive transit and facilitates efficient cellular delivery.

Liposomal encapsulation provides three critical advantages:

1. Gastric Protection — The phospholipid bilayer shields the iron-chelate complex from gastric acid degradation and interaction with dietary inhibitors, preserving its intact structure until reaching optimal absorption sites in the small intestine.

2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery. Liposomes are absorbed through the intestinal mucosa, and iron is released by liver enzymes, providing high gastrointestinal absorption and bioavailability.

3. Superior Bioavailability and GI Tolerance — Liposomal iron preparations have been demonstrated to improve the bioavailability of iron in the human body compared with conventional forms. The liposomal formulation minimizes direct contact between iron and the gastrointestinal mucosa, reducing the risk of nausea, cramping, and constipation commonly associated with conventional iron salts.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% ferric sodium EDTA, with purity grades available up to ≥99%.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects the iron-chelate complex during digestive transit and enhances cellular delivery through lipid-mediated pathways.

• Superior Bioavailability — Ferric sodium EDTA is recognized by the WHO, FDA, and EFSA as an iron source with elevated bioavailability and a good safety profile.

• Protection from Dietary Inhibitors — The EDTA chelation protects iron from phytates and polyphenols, enhancing iron absorption even in high-phytate food matrices.

• Gentle on Digestion — Liposomal encapsulation minimizes direct contact between iron and the gastrointestinal mucosa, reducing the risk of nausea, cramping, and constipation.

• Food Fortification Ready — Suitable for fortifying cereals, soy sauce, fish sauce, and other food vehicles.

• Water-Dispersible — Soluble in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical guidelines and regulatory standards commonly recommend specific limits for ferric sodium EDTA. According to GB 14880 (Chinese national standard for food nutritional fortification), the daily intake for adults should not exceed 92 mg of EDTA-iron (equivalent to 12 mg of iron), with the dose halved for children and adolescents. For fortifying complementary foods, 2 mg of iron from NaFeEDTA can be used for one daily serving to ensure EDTA levels are below the ADI for infants 6–8 months of age. Oral solution of sodium feredetate 190 mg (equivalent to 27.5 mg of iron/5 mL) is administered at 10 mL two to three times a day. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.