Product Detailed Description

Liposomal lycopene 30% — High Bioavailability Carotenoid Supplement

Product Overview

liposomal Lycopene 30% is a premium-grade dietary supplement ingredient delivering lycopene in an advanced liposomal delivery system. Lycopene (CAS 502-65-8) is a naturally occurring carotenoid and the pigment responsible for the red color of tomatoes, watermelons, and other red fruits. It is a highly unsaturated, straight-chain hydrocarbon composed of 11 conjugated and 2 non-conjugated carbon-carbon double bonds, with the molecular formula C₄₀H₅₆ and a molecular weight of 536.87 g/mol.

Lycopene is synthesized exclusively by plants and microorganisms; humans cannot synthesize it and must acquire it through dietary intake. It is the most abundant carotenoid in human plasma, with high concentrations also found in the testes, adrenal glands, and prostate. The compound is recognized for its potent antioxidant, anti-inflammatory, and cardioprotective properties, as well as its role in supporting prostate health and skin protection against UV-induced damage.

Why Liposomal Technology?

Native lycopene presents fundamental formulation challenges. The compound is practically insoluble in water and only slightly soluble in oils. Its highly unsaturated structure renders it extremely susceptible to oxidative degradation and cis-trans isomerization induced by light, heat, oxygen, pH changes, and active surfaces. These factors significantly limit its stability in food and supplement formulations, as well as its oral bioavailability.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability — The phospholipid bilayer shields lycopene from oxygen, light, and enzymatic degradation, significantly improving its stability during storage and gastrointestinal transit. The liposomal membrane protects lycopene from degradation by the body‘s enzymatic and immune systems and exhibits good stability against heat, pH, and shear stress.

2. Improved Bioavailability — Liposomal encapsulation improves lycopene bioavailability through enhanced dispersibility and sustained release. Liposomal lycopene demonstrated enteric-release properties, with minimal release in artificial gastric fluid (<28%) and up to 96% release in artificial intestinal fluid over 24 hours, exhibiting slow-release characteristics.

3. Enhanced Antioxidant Activity — Liposomal lycopene increased GSH-Px and T-AOC activities in serum and liver while decreasing MDA and CAT concentrations compared to free lycopene in animal studies. The encapsulation of lycopene effectively improves its antioxidant activity and ROS scavenging effect.

4. Water Dispersibility — Liposomal lycopene exhibits amphiphilic properties, being soluble in both water and oil, with good solubility and high transparency, suitable for a wide range of formulation applications.

Product Specifications

Key Features

• High Purity — Standardized to ≥30% lycopene by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation significantly enhances lycopene stability against heat, pH, and oxidative degradation, and improves dispersibility and bioavailability.

• Superior Pharmacokinetics — Liposomal lycopene achieved a Tmax of 7.45 h versus 4.45 h for free lycopene oil, with Cmax of 0.654 μg/mL versus 0.473 μg/mL, and AUC of 21.67 versus 12.38 mirog·h·mL⁻¹ in animal studies.

• Enhanced Relative Bioavailability — Liposomal lycopene demonstrated 154.42% relative bioavailability compared to oil-based lycopene preparation.

• Potent Antioxidant Activity — Lycopene’s antioxidant capacity is 2 times that of β-carotene and 100 times that of vitamin E.

• Cardiovascular Support — Clinical trials demonstrated that 15–30 mg/day lycopene supplementation for 8 weeks was associated with statistically significant reductions in systolic blood pressure.

• Prostate Health — Clinical studies have used 30 mg/day lycopene in men with prostate cancer or benign prostate hyperplasia.

• Water-Dispersible — Amphiphilic properties allow solubility in both water and oil; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated lycopene across a range of doses. A cardiovascular trial demonstrated that 8 weeks of treatment with a tomato nutrient complex standardized to contain 15 mg or 30 mg of lycopene was associated with statistically significant reductions in mean systolic blood pressure of 9.7 mmHg and 7 mmHg, respectively, compared to baseline. A clinical trial in men at increased risk of prostate cancer used 15 mg/day lycopene capsules or lycopene-rich foods for 6 months. A Phase II trial among men with high-grade prostatic intraepithelial neoplasia used 30 mg/day lycopene from tomato extract capsules. A Phase I study in metastatic prostate cancer patients identified the maximum tolerated dose as 150 mg/day in combination with docetaxel. For general antioxidant and cardiovascular support, 15–30 mg daily is commonly used. The Observed Safe Level methodology indicates up to 75 mg/day of lycopene is safe. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.