Liposomal ergothioneine 70% — High Bioavailability Longevity Vitamin Supplement

Product Overview

liposomal Ergothioneine 70% is a premium-grade dietary supplement ingredient delivering L-ergothioneine in an advanced liposomal delivery system. Ergothioneine (EGT) is a naturally occurring sulfur-containing amino acid (2-mercaptohistidine trimethylbetaine) and a potent antioxidant. Chemically, it exists in a thione tautomeric form in neutral aqueous solution, which confers remarkable structural stability and resistance to auto-oxidation.

Ergothioneine is synthesized exclusively by certain bacteria and fungi, particularly mushrooms, and is acquired by humans through dietary intake. It is not synthesized endogenously in mammals. EGT is actively accumulated in cells via the carnitine/organic cation transporter OCTN1 (SLC22A4), which is broadly expressed in human tissues including the liver, kidneys, eyes, brain, and skin. The unique tissue distribution and active accumulation of EGT in metabolically active and stress-prone tissues underscore its physiological role in cellular protection.

Ergothioneine has been characterized as a “longevity vitamin” and is increasingly recognized for its cytoprotective and anti-aging properties. However, its oral bioavailability and cellular uptake can be limited by transporter-dependent absorption kinetics. Liposomal encapsulation addresses these challenges by protecting EGT during digestive transit and facilitating efficient delivery to target tissues.

Why Liposomal Technology?

Conventional ergothioneine already exhibits superior chemical stability compared to other antioxidants. Studies have demonstrated that EGT has excellent light, thermal, and acid-base stability. However, its oral absorption and tissue distribution are dependent on the OCTN1 transporter, which can be a rate-limiting factor.

Liposomal encapsulation provides three critical advantages:

1. Digestive Protection — The phospholipid bilayer shields EGT from degradation and premature metabolism during digestive transit, preserving its intact molecular structure until reaching optimal absorption sites in the small intestine.

2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and complementing the OCTN1 transporter-mediated uptake pathway. This dual-route delivery system supports enhanced absorption and tissue distribution.

3. Mitochondrial Targeting — EGT actively accumulates in mitochondria, where it exerts its antioxidant effects. Liposomal delivery supports efficient cellular delivery, ensuring EGT reaches the mitochondria of target tissues including the liver, brain, and skin.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% ergothioneine by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects EGT during digestive transit and supports efficient cellular delivery, complementing OCTN1 transporter-mediated uptake.

• Mitochondrial Accumulation — EGT actively accumulates in mitochondria, where it protects mitochondrial integrity by maintaining mitochondrial signal and morphology, restoring membrane potential, and suppressing mitochondrial superoxide accumulation.

• Clinically Validated for Sleep Quality — A randomized, double-blind, placebo-controlled study demonstrated that 8 mg/day EGT for 16 weeks significantly improved subjective sleep quality compared to placebo (p < 0.05).

• Clinically Validated for Skin Health — An 8-week randomized, double-blind, placebo-controlled trial in 66 women aged 35–59 demonstrated that 30 mg/day EGT significantly improved skin aging parameters including wrinkle and spot reduction (all p < 0.01), with no adverse events reported.

• Longevity Vitamin — EGT is actively concentrated in tissues under oxidative stress and is increasingly recognized as a longevity-associated nutrient.

• Water-Soluble — Soluble in water (up to 100 mg/mL at 25°C); suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated ergothioneine across a range of doses. A physiologically based pharmacokinetic (PBPK) modeling study estimated that 8 mg/day of EGT for 16 weeks is optimal for attaining an effective plasma EGT concentration, with a randomized, double-blind, placebo-controlled study confirming significant improvement in subjective sleep quality at this dose (p < 0.05). An 8-week randomized, double-blind, placebo-controlled trial in 66 women used 30 mg/day EGT for skin health. An open-label pilot study in women with suboptimal ovarian reserve used 120 mg/day for three consecutive menstrual cycles, demonstrating increases in serum AMH and favorable shifts in FSH/E2 profiles. For general antioxidant and Mitochondrial Support, 8–30 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.