Product Detailed Description

Liposomal Melatonin 70% — High Bioavailability Sleep and Circadian Rhythm Supplement

Product Overview

liposomal Melatonin 70% is a premium-grade dietary supplement ingredient delivering melatonin in an advanced liposomal delivery system. Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine neurohormone synthesized primarily in the pineal gland from the essential amino acid tryptophan. It is closely linked to light exposure: its secretion surges as light intensity decreases in the evening and declines as light intensity increases in the morning, prompting the body to wake.

Melatonin is a pleiotropic regulator molecule that orchestrates multiple physiological functions through MT1 and MT2 melatonin receptors, which are specific G-protein coupled receptors involved in the regulation of sleep regulation and circadian rhythms. It also exerts potent antioxidant and anti-inflammatory effects through receptor-independent mechanisms, directly scavenging free radicals and protecting cells from oxidative damage.

Why Liposomal Technology?

Conventional melatonin presents significant formulation challenges. The compound undergoes extensive first-pass hepatic metabolism by CYP1A2 enzymes, resulting in extremely low oral bioavailability of approximately 15%. Its short elimination half-life of 30–60 minutes requires frequent dosing and limits sustained therapeutic effects.

Liposomal encapsulation provides three critical advantages:

1. Hepatic Protection — The phospholipid bilayer shields melatonin from first-pass metabolism in the liver, preserving its intact molecular structure until reaching systemic circulation.

2. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. A pharmacokinetic study in adult rats demonstrated that liposomal melatonin nanoformulations achieved higher bioavailability in the brain compared to free melatonin administration.

3. Sustained Release — Liposomal formulations provide controlled release of melatonin, with a prolonged release profile demonstrated by T1/2 of 81 minutes for melatonin-liposomes versus 26 minutes for melatonin-ethanol solution.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% melatonin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects melatonin from first-pass hepatic metabolism and provides sustained release with prolonged half-life.

• Clinically Validated for Sleep — Meta-analyses of randomized controlled trials demonstrate that melatonin significantly improves sleep quality, reduces sleep onset latency, and increases total sleep time.

• Circadian Rhythm Regulation — Melatonin resets the biological clock via MT2 receptors and suppresses neuronal firing via MT1 receptors.

• Antioxidant and Neuroprotective — Melatonin crosses the blood-brain barrier and the blood-retinal barrier, eliminating free radicals and protecting against oxidative damage.

• Water-Soluble — Soluble in water, acetone, ethyl acetate, and methanol; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical guidelines and commercial products commonly recommend 0.5–5 mg of melatonin per day, taken 1 hour before usual bedtime on the day of travel and 2 to 4 nights after arrival for jet lag management. A meta-analysis of 19 studies (1,683 patients) found that melatonin decreases time to fall asleep by 7 minutes, increases overall sleep time by 8 minutes, and improves sleep quality. Subgroup analysis from a systematic review indicated that high-dose exogenous melatonin (≥3 mg) reduced sleep onset latency parameters, while low-dose exogenous melatonin (<3 mg) significantly increased total sleep time parameters.

For shift work sleep support, the Cochrane systematic review found that melatonin (1 to 10 mg) after the night shift may increase sleep length during daytime sleep by 24 minutes and night-time sleep by 17 minutes compared to placebo. Doses of up to 300 mg per day have been reported in the literature without clinically significant adverse effects. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.