Product Detailed Description

liposomal GABA 70% — High Bioavailability Calming Neurotransmitter Supplement

Product Overview

Liposomal GABA 70% is a premium-grade dietary supplement ingredient delivering gamma-aminobutyric acid (GABA) in an advanced liposomal delivery system. GABA (CAS 56-12-2) is a naturally occurring inhibitory neurotransmitter in the human central nervous system and is also an important functional amino acid, widely present in the brain, nervous system, and various tissues within the body. The human body can synthesize a small amount of GABA on its own, but as stress increases, staying up late, and aging occur, the level of GABA in the body tends to be insufficient, requiring external supplementation.

GABA is the major inhibitory neurotransmitter in the brain, and imbalances of this neurotransmitter are associated with neurological diseases such as Alzheimer‘s and Parkinson’s disease, and psychological disorders including anxiety, depression, and stress. Emerging evidence has demonstrated that changes in both circulating and brain levels of GABA are associated with changes in gut microbiota composition, and that changes in GABA levels and microbiota composition play a role in modulating mental health.

Why Liposomal Technology?

Conventional oral GABA faces fundamental bioavailability challenges. It has long been believed that GABA cannot cross the blood-brain barrier, but studies that have assessed this issue are often contradictory and range widely in their employed methods. Conventional GABA supplementation faces significant bioavailability challenges due to the blood-brain barrier and poor gastrointestinal absorption.

Liposomal encapsulation provides three critical advantages:

1. Gastric Protection — The phospholipid bilayer shields GABA from stomach acid degradation, significantly enhancing its stability and biological utilization rate, allowing GABA to be absorbed and utilized by the body more efficiently.

2. Blood-Brain Barrier Penetration — In contrast to GABA, which only poorly penetrates into the brain after systemic administration, a liposomal suspension of phosphatidylserine (PS) and GABA (GABA-PS; liposome-entrapped GABA) has been shown to cross the blood-brain barrier and exert anticonvulsant effects in animal models.

3. Enhanced Cellular Uptake — Liposomal encapsulation technology addresses bioavailability limitations by encasing GABA molecules within lipid bilayers, dramatically improving cellular uptake and therapeutic efficacy. The liposomal delivery system increases GABA absorption rates by up to 90% compared to standard formulations.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% GABA by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects GABA from gastric acid degradation and significantly enhances stability and biological utilization rate.

• Blood-Brain Barrier Support — Liposomal GABA has been shown to cross the blood-brain barrier and exert central nervous system effects in animal models.

• Clinically Validated for Stress Relief — Clinical studies with GABA have shown it to produce significant antistress effects, as evidenced by changes in brain-wave patterns, pupil diameter, and heart rate, as well as reduction of salivary cortisol and chromogranin A levels.

• Sleep Quality Support — Oral consumption of 100 mg GABA for a week significantly shortened sleep latency and increased total non-rapid eye movement (non-REM) sleep time.

• Gut-Brain Axis Modulation — GABA is recognized as a potential postbiotic mediator in the gut-brain axis, modulating mental health through microbiota composition changes.

• Water-Dispersible — Good water dispersibility; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 100–300 mg of GABA per day. The typical dosage is 100 to 200 mg up to three times daily, with a general guideline of no more than 1,000 mg within a 4-hour period and no more than 3,000 mg within a 24-hour period. A randomized controlled trial in 30 women administered 200 mg of GABA daily, with many studies showing that doses ranging from 100 to 200 milligrams a day are effective. Oral consumption of 100 mg GABA for a week significantly shortened sleep latency and increased total non-REM sleep time. For general stress and sleep support, 100–200 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.