Product Detailed Description

Liposomal Oleuropein 40% — High Purity Olive Leaf Polyphenol Supplement

Product Overview

liposomal Oleuropein 40% is a premium-grade dietary supplement ingredient delivering oleuropein in an advanced liposomal delivery system. Oleuropein is a secoiridoid-type polyphenol and the characteristic marker compound of olive leaf, responsible for the bitter taste of unripe olives and the majority of the health-promoting properties attributed to olive products. Chemically, oleuropein is an ester of elenolic acid and hydroxytyrosol, with the molecular formula C₂₅H₃₂O₁₃ and a molecular weight of 540.52 g/mol.

Oleuropein has been extensively studied for its antioxidant, anti-inflammatory, anti-atherogenic, anti-cancer, antimicrobial, antiviral, hypolipidemic, and hypoglycemic activities. It is a central component of the Mediterranean diet, which has shown promising results in reducing the risk of non-communicable diseases including cardiovascular, liver, and bone diseases. However, its clinical potential is limited by poor oral bioavailability. Liposomal encapsulation addresses this challenge by protecting oleuropein from degradation and enhancing its delivery to target cells.

Why Liposomal Technology?

Conventional oleuropein exhibits low systemic bioavailability due to rapid hydrolysis into hydroxytyrosol in the gastrointestinal tract, extensive first-pass metabolism, and limited passive diffusion across intestinal epithelium.

Liposomal encapsulation provides three critical advantages:

1. Digestive Protection — The phospholipid bilayer shields oleuropein from enzymatic hydrolysis and premature conversion into hydroxytyrosol during digestive transit, preserving its intact molecular structure until reaching target cells.

2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. In a pharmacokinetic study in mice, oleuropein-loaded liposomes demonstrated a nearly 6-fold increase in bioavailability (AUC₀→∞ = 641.78 ± 103.764 μg/mL·hr) compared to free oleuropein solution (AUC₀→∞ = 104.11 ± 18.374 μg/mL·hr).

3. Sustained Release — Liposomal formulations provide controlled release of oleuropein, maintaining consistent active levels for prolonged antioxidant and anti-inflammatory activity.

Product Specifications

Key Features

• High Purity — Standardized to ≥40% oleuropein by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation provides nearly 6-fold higher bioavailability compared to free oleuropein in pharmacokinetic studies, with encapsulation efficiency up to 76.18% in optimized formulations.

• Antioxidant and Anti-Inflammatory — Oleuropein activates the Nrf2 pathway, reducing oxidative stress and modulating inflammatory responses.

• Geroprotective Potential — Oleuropein targets the hallmarks of aging, including mitochondrial dysfunction, DNA instability, and chronic inflammation.

• Water-Dispersible — Soluble in water, ethanol, and methanol; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Clean-Label Compatible — Non-GMO, no artificial additives; complies with ISO22000, HACCP, GMP, HALAL and KOSHER standards.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated oleuropein at doses ranging from 50 mg to 375 mg per day, with a systematic review reporting supplementation ranging from 5 mg/d hydroxytyrosol to 990 mL/d olive leaf infusion (320.8 mg oleuropein and 11.9 mg hydroxytyrosol). A 6-month randomized controlled trial in older adults with knee joint pain used 125 mg oleuropein twice daily. Another randomized controlled pilot study used 750 mg standardized olive leaf extract (50% oleuropein, 375 mg oleuropein) twice daily for 10 days in viral infections. Daily doses of 250–1000 mg olive leaf extract containing approximately 50–200 mg oleuropein have been administered for periods ranging from several weeks to 12 months without clinically relevant adverse events. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.