Product Detailed Description

liposomal Hydroxypinacolone Retinoate (HPR) 70% — High Bioavailability Gentle Retinoid Supplement

Product Overview

Liposomal Hydroxypinacolone Retinoate (HPR) 70% is a premium-grade dietary supplement ingredient delivering HPR in an advanced liposomal delivery system. Hydroxypinacolone retinoate (CAS 893412-73-2), also known as HPR or Granactive Retinoid, is a cosmetic-grade ester of all-trans retinoic acid (ATRA) with the molecular formula C₂₆H₃₈O₃ and a molecular weight of 398.58 g/mol. It is a yellow crystalline solid that is oil-soluble and is typically supplied in solution form (10% HPR in dimethyl isosorbide or plant oils) for cosmetic applications.

HPR is a new-generation retinoid that is increasingly used in skincare products for its anti-aging, acne-prevention, and skin-regulating properties. Unlike retinol, which requires two enzymatic conversion steps to become active retinoic acid, HPR binds directly to retinoic acid receptors, providing inherent retinoic acid activity without the need for metabolic decomposition. This direct mechanism of action is responsible for HPR's superior stability and reduced irritation profile compared to conventional retinoids.

Why Liposomal Technology?

Conventional HPR presents significant formulation challenges. The compound has poor stability in certain solvent systems, particularly in highly hygroscopic solutions where HPR has been found to be unstable. Studies have shown that at 45°C, only 74% of uncoated HPR remained after 12 weeks, and it is recommended to avoid heat above 60°C during formulation. Additionally, HPR faces limitations in skin penetration and delivery efficiency.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability — Liposomal encapsulation protects HPR from degradation and oxidative breakdown. The phospholipid bilayer shields HPR from environmental stressors including heat, light, and oxygen exposure. Research has demonstrated that compounding HPR with non-polar oils and antioxidants can greatly improve stability, and liposomal encapsulation provides an additional protective layer.

2. Enhanced Skin Penetration and Epidermal/Dermal Delivery — A nanoliposome platform co-delivering HPR and carnosine was developed to overcome the challenges of instability and poor skin penetration. The formulation demonstrated comprehensive pro-regenerative, anti-inflammatory, antioxidative, and anti-glycation effects, representing a promising nano-delivery strategy for advanced anti-aging skincare.

3. Reduced Irritation Potential — HPR is dermatologically tested to offer less irritation potential than retinol. Liposomal encapsulation further minimizes direct contact between HPR and the skin surface, enhancing tolerability for sensitive skin types. A 24-hour closed patch test with 30 healthy volunteers demonstrated that HPR-containing complexes had less irritation versus retinol.

4. Sustained Release for Prolonged Activity — Liposomal delivery provides a controlled-release profile that maintains steady levels of HPR at the target site, supporting prolonged retinoid receptor activation rather than a sharp peak followed by rapid decline.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% HPR by HPLC, with 99.0% purity available for premium cosmetic-grade applications.

• Liposomal Enhancement — Nanoliposome platform enhances stability and epidermal/dermal delivery, overcoming the instability and poor skin penetration challenges of free HPR.

• Direct Receptor Binding — HPR binds directly to retinoic acid receptors without undergoing metabolic decomposition into a more bioactive form, providing innate retinoic acid activity.

• Clinically Validated for Anti-Aging — An 8-week study in middle-aged Chinese women with mild photoaging demonstrated that a serum containing HPR significantly improved wrinkles, elasticity, hydration, barrier function, and pigmentation with excellent tolerability.

• Superior Stability vs. Retinol — HPR has demonstrated greater stability and lower skin irritation compared to retinol, serving as an effective substitute for retinoic acid with the advantage of no harmful side effects.

• Collagen and Elastin Synthesis — A synergistic complex containing HPR significantly increased expression levels of type I collagen genes col1a1b and col1a2, as well as the elastin gene Elna, by 217%, 184%, and 290%, respectively (P<0.05), surpassing the effects of individual components.

• Anti-Inflammatory Activity — The HPR-containing complex exhibited a more pronounced reduction of neutrophil aggregation compared to retinol (−25% vs. +1008%, P<0.05).

• Low Irritation Profile — A 24-hour closed patch test with 30 healthy volunteers found that the HPR complex had less irritation versus retinol. TGA data demonstrates safety of HPR up to concentrations of 1 per cent.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated HPR across a range of concentrations. A single-blind, split-face clinical trial involving 31 women compared 0.03% 9-cis HPR with 0.3% retinol applied to opposite sides of the face every evening for four weeks, demonstrating that daily 0.03% 9-cis HPR produced comparable or greater improvements in several measures, including wrinkles. For participants new to retinoids, a half-dose application was recommended during the first week. A 10-week UV irradiation study evaluated 0.03% and 0.1% concentrations of 9-cis HPR for mitigating UV-induced photoaging. For topical formulations, the recommended dosage ranges from 0.01% to 3.0% depending on the intended application and formulation.

Important Safety Information: HPR is classified as a topical retinoid. AAD 2024, SEGO 2023, and AEDV 2024 classify all topical retinoids (including HPR) as unwanted in pregnancy and lactation. Individuals with known hypersensitivity to retinoids should avoid use. Avoid using HPR with other strong exfoliants such as AHAs to prevent irritation. Benzoyl peroxide oxidizes retinoids, making them inactive. Use sun protection during HPR use, as retinoids can increase sun sensitivity. Pregnant or lactating women and children should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.