Product Detailed Description

liposomal Para-Aminobenzoic Acid PABA 70% — High Bioavailability Aminobenzoic Acid Supplement

Product Overview

Liposomal Para-Aminobenzoic Acid PABA 70% is a premium-grade dietary supplement ingredient delivering para-aminobenzoic acid (PABA) in an advanced liposomal delivery system. PABA (CAS 150-13-0), also known as 4-aminobenzoic acid, p-aminobenzoic acid, or vitamin B10, is an organic compound with the molecular formula C₇H₇NO₂ and a molecular weight of 137.14 g/mol. It occurs as a white to off-white crystalline powder, although commercial samples can appear gray, and it is only slightly soluble in water (approximately 4.41 g/L at 20°C). The pure substance crystallizes in colorless needles which upon ageing, particularly under the influence of air and light, acquire a yellowish cast. PABA is freely soluble in alcohol or boiling water; at room temperature, one part of PABA may be dissolved in 200 parts of water.

PABA is an aminobenzoic acid in which the amino group is para to the carboxy group. It was formerly classified as a member of the vitamin B complex and was historically used in sunscreening agents until it was found to also be a sensitizer. PABA is produced by certain bacteria, plants, and fungi, and is a precursor in the biosynthesis of folate (vitamin B9) and certain coenzymes. It is found in various food sources including grains, eggs, milk, and meat.

Why Liposomal Technology?

Conventional PABA presents significant formulation challenges. The compound is only slightly soluble in cold water (1 g in approximately 200 parts of water at room temperature) and undergoes rapid renal clearance following oral administration, limiting its systemic bioavailability. PABA is metabolized to para-aminohippuric acid and is excreted primarily in the urine.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability — Liquid crystal-drug formulations of PABA have demonstrated significantly improved bioavailability compared to PABA solution alone. Liposomal encapsulation utilizes similar phospholipid-based carrier technology to protect PABA during gastrointestinal transit and facilitate enhanced intestinal absorption.

2. Enhanced Solubility and Dispersibility — The phospholipid bilayer significantly improves the aqueous dispersibility of PABA, which is only slightly soluble in water. Liposomal PABA forms a stable dispersion in aqueous systems, suitable for functional beverages and liquid formulations.

3. Protection from Oxidation — PABA discolors on exposure to light and air. Liposomal encapsulation protects PABA from oxidative degradation during storage and digestive transit, preserving its intact molecular structure until reaching optimal absorption sites.

4. Sustained Release for Prolonged Biological Activity — Liposomal delivery provides a sustained-release profile that maintains steady plasma levels of PABA, supporting prolonged antioxidant and neurotransmitter-modulating activity rather than a sharp peak followed by rapid decline.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% PABA by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation improves aqueous dispersibility, protects PABA from oxidative degradation, and enhances intestinal absorption.

• Neurotransmitter Modulation — Experimental and clinical evidence demonstrates that PABA enhances serotonin and dopamine synthesis by activating key enzymes including tryptophan hydroxylase and tyrosine hydroxylase, thereby stabilizing mood and improving cognitive function.

• Anti-Inflammatory Activity — PABA suppresses neuroinflammation by inhibiting NF-κB signaling and cytokine production (including IL-1β and TNF-α) while scavenging reactive oxygen species (ROS) to mitigate oxidative stress and protect neuronal integrity.

• Folate Synthesis Cofactor — PABA is a precursor in the biosynthesis of folate (vitamin B9) and is a structural component of folic acid and certain coenzymes.

• Skin and Hair Support — PABA has been historically used to support skin health and hair pigmentation. A study of 460 patients with gray hair who took 100 mg of PABA three times a day led to pigment restoration within 2–4 months in 82% of patients.

• Water-Dispersible — Liposomal powder offers significantly improved aqueous dispersibility compared to free PABA; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and historical usage data provide guidance on PABA dosing. Prophylactic doses of 500 to 1,000 mg/day have been used. A study of 460 patients with gray hair who took 100 mg of PABA three times a day (300 mg/day) led to pigment restoration within 2–4 months in 82% of patients. Clinical use of PABA at doses of 10 grams per day or more has produced nausea, vomiting, acidosis, pruritus, rash, fever, and methaemoglobinemia. Doses of 12 g/day (corresponding to 200 mg/kg body weight for a 60 kg human) have been associated with hepatic injury. For general cellular and antioxidant support, 100–500 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: A daily dose of more than 12 g of PABA has been reported to be unsafe and can bring about serious side effects such as liver, kidney, and blood problems. PABA was historically used in sunscreens but was removed from the FDA OTC sunscreen monograph in 2026 because it is not generally recognized as safe and effective (GRASE) as a sunscreen active ingredient due to the risk of allergic skin reactions and photosensitivity. PABA is listed as a prohibited cosmetic ingredient in the European Union (II/167). This product is not intended for use as a sunscreen or topical photoprotective agent. Individuals with known hypersensitivity to PABA or related compounds should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. PABA may interact with sulfonamide antibiotics and should not be used concurrently without medical supervision.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.