Product Detailed Description

Liposomal hydroxytyrosol 10% — High Bioavailability Olive Polyphenol Supplement

Product Overview

liposomal Hydroxytyrosol 10% is a premium-grade dietary supplement ingredient delivering hydroxytyrosol in an advanced liposomal delivery system. Hydroxytyrosol (HT) is a phenylethanoid and member of the class of catechols, chemically characterized as benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. It is isolated from Olea europaea and is the primary polyphenol responsible for the health benefits associated with the Mediterranean diet. Hydroxytyrosol is a pale-yellow viscous liquid that is miscible with water and exhibits characteristic slightly bitter taste.

Hydroxytyrosol has been extensively studied for its broad-spectrum pharmacological activities, including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, and anticancer effects. It is one of the most potent natural antioxidants, with an oxidative radical absorbance capacity reported to be 30 times that of vitamin C. However, its clinical utility is limited by rapid first-pass metabolism. Liposomal encapsulation addresses this challenge by protecting hydroxytyrosol from degradation and enhancing its delivery to target cells.

Why Liposomal Technology?

Conventional hydroxytyrosol exhibits low systemic bioavailability due to rapid first-pass metabolism. Circulating hydroxytyrosol is predominantly present as sulfate and glucuronide conjugates, and free parent compound levels are comparatively low. The elimination half-life of hydroxytyrosol has been reported to be approximately 2–3 hours, reflecting efficient metabolic clearance.

Liposomal encapsulation provides three critical advantages:

1. Digestive Protection — The phospholipid bilayer shields hydroxytyrosol from enzymatic degradation and premature metabolism during digestive transit, preserving its intact molecular structure until reaching target cells.

2. Enhanced Cellular Uptake — liposomes are small (15–1000 nm) spherical vesicular systems comprising one or more bilayers formed by phospholipids, surrounding aqueous cores. This structure allows for the incorporation of hydrophilic substances like hydroxytyrosol directly into the core, facilitating efficient cellular delivery.

3. Enhanced Stability and Antioxidant Activity — Liposomal formulations have been shown to be more stable and active as an antioxidant than the free form in solution. The encapsulation of hydroxytyrosol in liposomes enhances its antioxidant activity and is a promising formulation for prolonging biological activity time.

Product Specifications

Key Features

• High Purity — Standardized to ≥10% hydroxytyrosol by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances stability and antioxidant activity compared to free hydroxytyrosol.

• Superior Antioxidant Capacity — Hydroxytyrosol demonstrates an oxidative radical absorbance capacity 30 times that of vitamin C.

• Cardiovascular Protection — Hydroxytyrosol protects the cardiovascular system by avoiding oxidation of LDL cholesterol and maintaining normal blood HDL cholesterol concentrations, thus helping to prevent atherosclerosis.

• Neuroprotective Effects — Reduces oxidative stress, preserves nitric-oxide bioavailability, lowers inflammatory markers, and supports favorable intrinsic connectivity on the neurovascular axis.

• Clinically Validated — Chronic supplementation with 15 mg/day for 16 weeks significantly improved antioxidant and anti-inflammatory status in individuals with overweight and prediabetes, with reduced oxLDL levels, protein carbonyls, and 8-OHdG.

• Water-Dispersible — Soluble in water and ethanol; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 5–15 mg of hydroxytyrosol per day for chronic supplementation, with acute doses of 30–60 mg used in some applications. A human supplementation study using 15 mg/day for 16 weeks significantly improved antioxidant and anti-inflammatory status in individuals with overweight and prediabetes. The FDA GRAS notice specifies an intended use level of 5–10 mg per serving in bakery products and beverages. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.