Product Detailed Description

liposomal L-Histidine 80% — High Bioavailability Essential Amino Acid Supplement

Product Overview

Liposomal L-Histidine 80% is a premium-grade dietary supplement ingredient delivering L-histidine in an advanced liposomal delivery system. L-Histidine (CAS 71-00-1), also known as (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid or α-amino-1H-imidazole-4-propionic acid, is an essential proteinogenic amino acid with the molecular formula C₆H₉N₃O₂ and a molecular weight of 155.16 g/mol. It occurs as white crystals or a crystalline powder that is odorless and has a slightly bitter taste, and is soluble in water.

L-Histidine is one of the nine essential amino acids in humans. It is a basic amino acid characterized by an imidazole side chain, which confers unique chemical properties including metal chelation, antioxidant activity, and pH buffering capacity. L-Histidine is particularly important as the direct precursor for carnosine synthesis in skeletal muscle and brain tissue, and also serves as a precursor for histamine, a critical mediator of immune and inflammatory responses. The compound is found in high-protein foods including meat, poultry, fish, dairy products, and eggs.

Why Liposomal Technology?

Conventional L-histidine presents significant formulation challenges. The compound is absorbed from the small intestine via an active transport mechanism requiring the presence of sodium, which can be saturated at high doses. Additionally, L-histidine competes with other amino acids for transport across the intestinal epithelium, limiting the fraction that reaches systemic circulation.

Liposomal encapsulation provides four critical advantages:

1. Exceptionally High Encapsulation Efficiency and Sustained Release — A stability study comparing amino acid-encapsulated liposomes versus double emulsions demonstrated that encapsulation efficiencies of amino acids in liposomes were over 97%, with cumulative release rates below 30% for 5 days. The study confirmed that liposomal encapsulation provides excellent retention and sustained release of amino acids, making it an ideal delivery system for essential amino acids including L-histidine.

2. Protection from Competitive Transport — Liposomal encapsulation bypasses the sodium-dependent active transport mechanism by utilizing lipid-mediated absorption pathways, ensuring efficient delivery of L-histidine to target cells independent of the amino acid ratio in the intestinal lumen.

3. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism complements the physiological transport pathways utilized by free L-histidine, supporting enhanced systemic absorption and tissue distribution.

4. Sustained Release for Prolonged Biological Activity — Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting prolonged carnosine synthesis and antioxidant activity rather than a sharp peak followed by rapid decline.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-histidine by HPLC, with USP/EP/FCC grade assay of 98.5%–101.5% on dried basis available.

• Liposomal Enhancement — Liposomal encapsulation achieves >97% encapsulation efficiency with <30% cumulative release over 5 days, providing sustained delivery and protection from competitive transport.

• Carnosine Precursor — L-Histidine is the direct precursor to carnosine (β-alanyl-L-histidine), a potent endogenous antioxidant and anti-glycation dipeptide synthesized in skeletal muscle and brain tissue.

• Metabolic Health Support — Supplementation with 4.0–4.5 g histidine/d and increased dietary histidine intake are associated with decreased BMI, adiposity, markers of glucose homeostasis (HOMA-IR, fasting blood glucose, 2-h postprandial blood glucose), proinflammatory cytokines, and oxidative stress.

• Immune Function Support — Histidine is the precursor for histamine, which mediates the growth and functionality of immune cells. In vitro studies show that histidine addition to culture medium prevented apoptosis, enhanced cell growth, and elevated antibody production in lymphocytes.

• Clinically Studied for Safety — Histidine loading (0.054 g/kg) has been safely applied in pediatric leukemia, and small clinical trials in prediabetes and obesity (4–8 g/day) improved postprandial glucose and increased mucosal-associated invariant T (MAIT) cells.

• Water-Soluble — Soluble in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and regulatory guidelines commonly recommend varying doses of L-histidine depending on the application. The current estimated requirement for histidine for healthy adults is 8–12 mg per kg body weight per day. Human research has used between 1 gram and 8 grams per day. Small clinical trials in prediabetes and obesity used 4–8 g per day and demonstrated improved postprandial glucose, increased MAIT cells, and shifted gut microbiota. Supplementation with doses of 4.0–4.5 g histidine/d and increased dietary histidine intake are associated with decreased BMI, adiposity, markers of glucose homeostasis, proinflammatory cytokines, and oxidative stress. At high intakes of histidine (>24 g/d), studies report adverse effects such as decreased serum zinc and cognitive impairment. For general immune and antioxidant support, 1–4 g daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.