Product Detailed Description

liposomal L-Isoleucine 80% — High Bioavailability Branched-Chain Amino Acid Supplement

Product Overview

Liposomal L-Isoleucine 80% is a premium-grade dietary supplement ingredient delivering L-isoleucine in an advanced liposomal delivery system. L-Isoleucine (CAS 73-32-5), also known as 2-amino-3-methylvaleric acid or α-amino-β-methylvaleric acid, is an essential branched-chain amino acid with the molecular formula C₆H₁₃NO₂ and a molecular weight of 131.17 g/mol. It occurs as white to off-white crystals, shiny flakes, or a crystalline powder, and is soluble in water (approximately 41.2 mg/mL at 25°C) and soluble in 1 M hydrochloric acid forming a clear, colorless solution. L-Isoleucine is one of the three BCAAs, along with leucine and valine, and is characterized by a branched aliphatic side chain. It is an isomer of L-leucine, differing in the position of the side chain: in L-isoleucine, the methyl group is on the β-carbon of the amino acid chain, rather than the γ-carbon as in L-leucine. L-Isoleucine is biosynthesized from threonine through the formation of α-ketobutyrate and is degraded to acetyl CoA and propionyl CoA.

L-Isoleucine is classified as an essential amino acid because the human body cannot synthesize it, requiring dietary intake. The most important dietary sources are meat, dairy products, eggs, soy protein, and legumes. L-Isoleucine plays a critical role in muscle tissue repair, cellular energy production, and hemoglobin formation, and also functions as a glucogenic amino acid that helps regulate blood glucose levels. Isoleucine provides a source of nitrogen for transport to the liver and kidney.

Why Liposomal Technology?

Conventional L-isoleucine presents significant formulation and bioavailability challenges. Traditional crystalline amino acids rely on specific, saturable active transport systems in the brush border membrane of the small intestine. When high doses of standard BCAAs are ingested, these carrier proteins quickly become saturated, leaving a substantial portion of the amino acids unabsorbed. Furthermore, isoleucine competes with leucine and valine for both absorption in the gut and entry into muscle tissue, which can limit its availability when supplemented in isolation or imbalanced ratios. Free-form BCAAs often present poor water solubility, severe bitterness, and mucosal irritation.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Encapsulation and Retention — A stability study evaluating liposomal nanovesicles loading isoleucine-containing bioactive peptides demonstrated that the encapsulation efficiency of isoleucine-proline-proline (IPP) in liposomal vesicles was maximized through optimized preparation methods. The phospholipidic nanovesicles, produced by modified ethanol injection-microchannel technique, were smaller with lower polydispersity index than non-ionic surfactant vesicles, demonstrating the technical feasibility of efficient isoleucine encapsulation within liposomal carriers.

2. Biomimetic Absorption Mechanism — Liposomal L-isoleucine utilizes a biomimetic delivery mechanism to circumvent the saturable transport barriers of the small intestine. Because the outer surface of the liposome mimics the phospholipid bilayer of cell membranes, liposomes are absorbed through lipid-mediated pathways and endocytosis, bypassing the competitive BCAA transporter system entirely.

3. Improved Formulation Stability and Taste Profile — Liposomal microencapsulation provides taste-masking, reducing the bitterness and mucosal irritation associated with free-form BCAAs. The liposomal matrix also enhances formulation stability, making it ideal for use in powders, capsules, liquid sachets, and functional beverages.

4. Balanced BCAA Delivery — Liposomal encapsulation ensures efficient delivery of isoleucine in balance with other BCAAs. Research suggests that leucine taken alone may actually be more anabolic than leucine taken with isoleucine and valine, due to competition for both absorption in the gut and entry into muscle tissue. Liposomal L-isoleucine ensures that this essential BCAA is delivered efficiently, supporting balanced BCAA availability for muscle metabolism.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-isoleucine, with USP/EP/JP grade assay of 98.5%–101.5% on dried basis available.

• Liposomal Enhancement — Liposomal nanovesicle encapsulation demonstrated high encapsulation efficiency for isoleucine-containing peptides, with optimized preparation methods maximizing loading capacity.

• Muscle Growth and Protein Synthesis — Isoleucine is essential for muscle growth and protein synthesis, and it may aid in muscle recovery.

• Muscle Soreness Reduction — When isoleucine is taken as part of a BCAA supplement, it seems to reduce post-exercise muscle soreness and markers of muscle damage.

• Endurance and Muscle Repair — L-Isoleucine is known for its ability to help endurance and assist in the repair and rebuilding of muscle.

• Hemoglobin Formation and Glucose Regulation — Isoleucine is needed for hemoglobin formation and helps regulate blood glucose levels.

• Complete Taste-Masking — Liposomal microencapsulation reduces the bitterness and mucosal irritation associated with free-form BCAAs.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The standard dosage for isoleucine is 48–72 milligrams per kilogram of bodyweight, assuming a non-obese person. For a 70 kg adult, this equates to approximately 3,360–5,040 mg per day. A combination dose is 20 grams of combined BCAAs, with a balanced ratio of leucine and isoleucine. Commercial BCAA supplements typically provide 450 mg of L-isoleucine per serving, with a recommended intake of 3 capsules daily during meals. The WHO has derived similar recommendations of 20 mg isoleucine per kg body weight per day. For general muscle support, the standard dosage of 48–72 mg/kg body weight is commonly used. Amino acids are best absorbed when taken half an hour before eating or sleeping. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.