Product Detailed Description

Liposomal L-leucine 80% — High Bioavailability Muscle Protein Synthesis Supplement

Product Overview

liposomal L-Leucine 80% is a premium-grade dietary supplement ingredient delivering L-leucine in an advanced liposomal delivery system. L-Leucine (CAS 61-90-5), also known as L-2-amino-4-methylpentanoic acid or (S)-2-amino-4-methylpentanoic acid, is an essential branched-chain amino acid with the molecular formula C₆H₁₃NO₂ and a molecular weight of 131.17 g/mol. It occurs as white to off-white crystals or crystalline powder or shiny flakes. L-Leucine is a hydrophobic amino acid and is one of the three branched-chain amino acids (BCAAs), along with isoleucine and valine. It is the most abundant amino acid in food proteins and tissues, with the most important food sources being soybean, beef, peanuts, fish, wheat germ, almonds, chicken, eggs, and oats.

L-Leucine is classified as an essential amino acid because the human body cannot synthesize it, requiring dietary intake. L-Leucine is absorbed in the small intestine in its free form or as part of peptides and is transported to the liver, where a portion is used for protein synthesis and the rest is distributed to body tissues. Most L-leucine metabolism occurs in muscular tissue, where it undergoes reversible transamination to alpha-ketoisocaproate, followed by irreversible oxidative decarboxylation to isovaleryl-CoA and acyl-CoA derivatives, ultimately producing acetoacetate and acetyl-CoA for Energy Metabolism.

Why Liposomal Technology?

Conventional L-leucine presents significant absorption challenges. Anabolic resistance is a well-established phenomenon during aging, with cells becoming more resistant to turning on protein synthesis, and research indicates that older adults need twice as much leucine compared to younger adults for similar activation of MPS. This increased leucine requirement can be partially explained by increased retention of orally ingested leucine in the gut, which is retained twice as much compared to young adults, limiting the amount of leucine that makes it into the bloodstream.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Absorption and Bioavailability — Liposomal L-leucine delivers superior bioavailability to support muscle protein synthesis, recovery, and performance. Lipoamino acids are encapsulated in liposomes, allowing for superior bioavailability compared to standard amino acids, ensuring more of the active nutrient reaches the bloodstream and cells.

2. Targeted Nutrient Delivery — Liposomal technology delivers amino acids directly into cells, improving their effectiveness in muscle repair, recovery, and protein synthesis.

3. Protection from Gastrointestinal Degradation — Unlike some free-form amino acids, lipoamino acids reduce the risk of stomach irritation or degradation in the GI tract, making them suitable for sensitive users. The phospholipid bilayer shields L-leucine from premature metabolism in the gastrointestinal tract, preserving its intact structure until reaching optimal absorption sites.

4. Sustained Release and Formulation Stability — Lipoamino acids offer greater formulation stability, making them ideal for use in powders, capsules, liquid sachets, and functional beverages. Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting prolonged mTOR activation and protein synthesis.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-leucine, with pharmaceutical-grade assay of 98.5%–101.0% on anhydrous basis available.

• Liposomal Enhancement — Liposomal encapsulation delivers superior bioavailability to support muscle protein synthesis, recovery, and performance.

• Potent mTOR Activator — L-Leucine is the most potent activator of protein synthesis among all amino acids. Cells sense leucine levels and respond by turning on protein synthesis via mTOR, a master-regulator of protein synthesis.

• Clinically Studied for Muscle Protein Synthesis — Leucine supplementation of a low-protein (6.25 g) mixed macronutrient beverage can be as effective as a high-protein dose (25 g) at stimulating increased MPS rates when supplemented with a high (5.0 g total leucine) amount of leucine.

• Sarcopenia and Aging Support — Anabolic resistance during aging can be partly ameliorated with extra leucine, as research indicates that older adults need twice as much leucine compared to younger adults for similar activation of MPS.

• Metabolic Regulation — L-Leucine stimulates protein synthesis, controls satiety by acting directly on the hypothalamus and stimulating leptin release, controls body weight by reducing fatty mass, controls energy expenditure, and improves glucose metabolism and sensitivity.

• GRAS and FDA Affirmed — L-Leucine is a food additive (E 641) authorized in the European Union with assay specification of 98.5%–101.0% on the anhydrous basis.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend varying doses of L-leucine depending on the application. The standard leucine dosage is 2–10 grams, with leucine tending to be supplemented in the 2,000–5,000 mg range for acute usage. The AESAN has recommended a maximum daily amount of 2,950 mg of L-leucine in food supplements. In accordance with the FAO/WHO/UNU joint technical report, the requirements for L-leucine in adults are 39 mg/kg body weight per day. The usual daily intake of L-leucine in the Western population is between 6 and 9 g per person per day, although male adults between 50–70 years old may take up to 14 g/day. L-Leucine is best absorbed when taken between meals or in a fasted state, or alongside meals with inherently low protein content. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.