Product Detailed Description

Liposomal L-Tyrosine 70% — High Bioavailability Cognitive Performance Supplement

Product Overview

liposomal L-Tyrosine 70% is a premium-grade dietary supplement ingredient delivering L-tyrosine in an advanced liposomal delivery system. L-Tyrosine (CAS 60-18-4), also known as (S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, is a non-essential aromatic amino acid with the molecular formula C₉H₁₁NO₃ and a molecular weight of 181.19 g/mol. It is a white crystalline powder that is very slightly soluble in water (approximately 0.45 g/L at 25°C) and practically insoluble in ethanol. L-Tyrosine is synthesized in animals from L-phenylalanine via the enzyme phenylalanine hydroxylase and is a precursor for the biosynthesis of dopamine, epinephrine, norepinephrine, and melanin.

L-Tyrosine is a conditionally essential amino acid, meaning that under normal physiological conditions the body can synthesize sufficient amounts from phenylalanine, but during periods of high stress, the demand for catecholamine synthesis may exceed endogenous production capacity. L-Tyrosine is an intermediary in the biosynthesis of dopamine, epinephrine, and norepinephrine, and the first step of the catecholamine biosynthetic route from L-tyrosine is catalyzed by tyrosine hydroxylase. In the central nervous system, catecholamine neurotransmitters participate in regulating activities such as awakening, attention, and mood.

Why Liposomal Technology?

Conventional L-tyrosine presents significant formulation challenges. The compound has extremely poor water solubility in physiological media (approximately 0.45 mg/mL at neutral pH), which severely limits its dissolution rate and intestinal absorption. Additionally, free L-tyrosine undergoes rapid metabolic clearance, has a short in vivo half-life, and exhibits unstable bioavailability after oral administration. L-Tyrosine uptake can be further reduced by competing amino acids from dietary protein.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Solubility and Bioavailability — liposomes can effectively encapsulate poorly water-soluble amino acids such as tyrosine, increasing their apparent solubility and absorption profiles in aqueous biological systems. Nano-formulations significantly improve solubility and dispersion uniformity in aqueous and biological environments, with nanoscale particle size facilitating transcellular absorption and blood-brain barrier penetration. Depending on the ingredient, absorption may increase by 60–70% or two to three times.

2. Protection from Enzymatic Degradation — Nano-carrier protection shields L-tyrosine from enzymatic degradation and pH-induced inactivation in the gastrointestinal tract, enhancing chemical stability. The phospholipid bilayer preserves the intact molecular structure until reaching optimal absorption sites in the small intestine.

3. Enhanced Brain Availability — Lipid nanoparticles can protect L-tyrosine during gastrointestinal transit, promote lymphatic circulation absorption, and enhance accumulation in brain and neural tissues, which is especially suitable for neurological and cognitive intervention applications. This is particularly important because dopamine neurons in the prefrontal cortex—a brain region involved in response inhibition and working memory—are highly tyrosine-dependent.

4. Sustained Release for Prolonged Cognitive Support — Nano-carriers enable sustained and slow release, prolonging action time and reducing frequent administration. Liposomal delivery provides a controlled-release profile that maintains steady plasma amino acid levels, supporting prolonged cognitive benefits.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% L-tyrosine by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation increases apparent solubility and absorption profiles, with absorption increases of 60–70% to two or three times compared to free L-tyrosine.

• Catecholamine Precursor — L-Tyrosine is an intermediary in the biosynthesis of dopamine, epinephrine, and norepinephrine, and the EFSA has concluded that L-tyrosine contributes to the normal synthesis of dopamine.

• Clinically Validated for Cognitive Function Under Stress — L-Tyrosine supplementation has been shown to mitigate working memory decrements during cold exposure and reduce cognitive impairments during environmental stress such as cold induction, acoustic noise, or demanding tasks.

• Clinically Validated for Cognitive Fatigue — Health Canada monograph supports the claim that L-tyrosine helps to decrease cognitive fatigue due to physically stressful situations (e.g., extended wakefulness, exposure to cold, excessive noise) at a dose of 10 g, 1–2 times per day.

• Dopamine Synthesis Support — The EFSA NDA Panel has concluded that L-tyrosine does contribute to the synthesis of dopamine, supporting its role as a cognitive and mood-support nutrient.

• Water-Dispersible — Liposomal powder offers dramatically improved aqueous dispersibility compared to free L-tyrosine; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated L-tyrosine across a range of doses depending on the application. For general cognitive support, effective doses are usually around 150 mg of L-tyrosine per kilogram of body weight, or about 10 grams for someone who weighs 70 kilograms. For decreasing cognitive fatigue due to physically stressful situations, the Health Canada monograph recommends 10 g, 1–2 times per day, taken up to one hour before or during periods of physical stress. Clinical studies have also used 100–150 mg/kg per day for cognitive performance, while manufacturers commonly recommend 500–1,500 mg/day for general supplementation. L-Tyrosine should be taken on an empty stomach for optimal absorption and benefits, as uptake can be reduced when competing amino acids from dietary protein are present. Tyrosine levels peak 15–60 minutes after taking it, and effects last approximately 1–3 hours, so it should be taken just before the high-stress situation. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.