Product Detailed Description

Liposomal L-phenylalanine 80% — High Bioavailability Essential Amino Acid Supplement

Product Overview

liposomal L-Phenylalanine 80% is a premium-grade dietary supplement ingredient delivering L-phenylalanine in an advanced liposomal delivery system. L-Phenylalanine (CAS 63-91-2), also known as (S)-2-amino-3-phenylpropanoic acid or β-phenyl-L-alanine, is an essential aromatic amino acid with the molecular formula C₉H₁₁NO₂ and a molecular weight of 165.19 g/mol. It is a white, crystalline powder that is sparingly soluble in water (27 g/L at 20°C) and is a member of the aromatic amino acid family, containing a benzene ring in its side chain.

L-Phenylalanine is an essential proteinogenic amino acid that the human body cannot synthesize on its own and must obtain through dietary intake. It is found in high-protein foods including meat, cottage cheese, and wheat germ. As a key metabolic precursor, L-phenylalanine is converted to tyrosine by the enzyme phenylalanine hydroxylase, which is then used in the biosynthesis of the neurotransmitters dopamine and norepinephrine—critical mediators of mood, focus, and mental alertness.

Why Liposomal Technology?

Conventional L-phenylalanine presents significant formulation challenges. As a large neutral amino acid (LNAA), it competes with other LNAAs (leucine, isoleucine, valine, tryptophan, and tyrosine) for transport across the intestinal epithelium and the blood-brain barrier via the L-type amino acid transporter (LAT1). This competition limits the fraction of orally administered L-phenylalanine that reaches systemic circulation and the central nervous system.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Brain Availability — Lipid-based carriers and liposomal delivery systems improve the permeability and transport efficiency of L-phenylalanine, enhancing its availability to the central nervous system. Liposomal encapsulation bypasses the competitive LNAA transport pathway by utilizing lipid-mediated absorption mechanisms, ensuring efficient delivery of the amino acid to target tissues including the brain.

2. Sustained Release for Balanced Neurotransmitter Effect — Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting a balanced neurotransmitter effect rather than a sharp peak in stimulation. Neuro-nutrition formulations benefit from sustained-release formats that help maintain steady effects instead of sharp peaks and subsequent crashes.

3. Enhanced Stability and Dispersibility — The phospholipid bilayer protects L-phenylalanine from premature degradation during digestive transit and provides excellent water dispersibility for use in aqueous formulations including functional beverages and liquid supplements.

4. Clean-Label Compatible — The phospholipid carrier is sourced from plant-derived lipids, keeping the entire delivery system aligned with clean-label and vegan-friendly positioning.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% L-phenylalanine, with pharmaceutical-grade assay of 98.5%–101.5% available.

• Liposomal Enhancement — Lipid-based carrier system improves brain availability by enhancing permeability and transport efficiency across biological membranes.

• Neurotransmitter Precursor — L-Phenylalanine is the direct precursor to tyrosine, which is subsequently converted to dopamine and norepinephrine—key neurotransmitters for mood regulation, focus, and mental alertness.

• Sustained Release Profile — Liposomal delivery provides balanced, phased release for steady effects rather than sharp peaks and crashes.

• Appetite Regulation Support — L-Phenylalanine has been described in research as a strong trigger for cholecystokinin (CCK), a hormone that produces feelings of fullness and food satisfaction, which can reduce overall food intake.

• Pain Tolerance Support — L-Phenylalanine may enhance pain tolerance and has been studied for premenstrual syndrome and migraine headaches.

• Water-Dispersible — Soluble in water (27 g/L at 20°C); suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 500 mg of L-phenylalanine per serving, with a typical dosage of 1 capsule daily, or up to 1–3 capsules daily as needed. Amino acids are best absorbed when taken half an hour before eating or sleeping. For best results, L-phenylalanine should be taken with cofactor vitamins B6 and C to support its metabolic conversion to tyrosine and downstream neurotransmitters. For cognitive and nootropic applications, moderate, divided doses and sustained-release formats help maintain steady effects instead of sharp peaks.

Important Safety Information: L-Phenylalanine is contraindicated in individuals with phenylketonuria (PKU), tyrosinemia (type I or II), or melanoma (pigmented type). It should not be co-administered with monoamine oxidase inhibitors (MAO inhibitors). Pregnant or lactating women and children should not take L-phenylalanine supplements without medical supervision.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.