Product Detailed Description

Liposomal L-theanine 70% — High Bioavailability Calm Focus Supplement

Product Overview

liposomal L-Theanine 70% is a premium-grade dietary supplement ingredient delivering L-theanine in an advanced liposomal delivery system. L-Theanine (CAS 3081-61-6), also known as γ-glutamylethylamide, N5-ethyl-L-glutamine, or 5-N-ethyl-L-glutamine, is a unique non-protein amino acid with the molecular formula C₇H₁₄N₂O₃ and a molecular weight of 174.20 g/mol. It is a white, crystalline powder with an off-white to white appearance and a characteristic odor and taste, and is freely soluble in water. L-Theanine is predominantly biosynthesized in tea plants (Camellia sinensis), where it contributes to the characteristic umami and fresh flavor that is highly valued in global tea-drinking culture.

L-Theanine is the primary amino acid responsible for the calming yet alert state associated with tea consumption. Unlike pharmaceutical sedatives, L-theanine promotes relaxation without causing drowsiness or impairing cognitive function. It has been extensively studied for its effects on stress management, cognitive performance, sleep quality, and neuroprotection. Emerging food applications include cognitive-enhancing beverages, plant-based preservatives, and low-sodium umami enhancers.

Why Liposomal Technology?

Conventional L-theanine presents formulation challenges. The compound is highly polar, which limits its passive diffusion across intestinal cell membranes and the blood-brain barrier. It also competes with other large neutral amino acids for transport via shared amino acid transporters, which can limit the fraction of orally administered L-theanine that reaches systemic circulation and the central nervous system.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Absorption and Bioavailability — Liposomal L-theanine is designed to enhance the absorption and effectiveness of theanine. Encapsulated in lipid bilayers, this white to off-white powder delivers theanine directly to cells, maximizing its potential to reduce stress, improve focus, and support relaxation without drowsiness. Liposomal delivery systems bypass the competitive amino acid transport pathway by utilizing lipid-mediated absorption mechanisms.

2. Enhanced Brain Availability — L-Theanine crosses the blood-brain barrier via the L-type amino acid transporter (LAT1), which is shared with other large neutral amino acids. Liposomal encapsulation provides an alternative delivery route that improves permeability and transport efficiency across biological membranes, supporting enhanced central nervous system availability.

3. Controlled Release for Sustained Effect — Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting balanced neurotransmitter modulation rather than a sharp peak followed by rapid decline. Theanine liposomes prepared by two methods had optimal sizes of 154.8 and 169.0 nm, which can effectively accumulate in target tissues.

4. Water Dispersibility and Formulation Flexibility — Liposomal L-theanine is soluble in water and exhibits excellent dispersibility, making it suitable for a wide range of formulations including capsules, powders, functional beverages, and liquid supplements.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% L-theanine by HPLC, with ≥98% assay available for pharmaceutical-grade applications.

• Liposomal Enhancement — Lipid bilayer encapsulation enhances the absorption and effectiveness of theanine, delivering it directly to cells and maximizing its potential to reduce stress, improve focus, and support relaxation without drowsiness.

• Clinically Validated for Stress Reduction — AlphaWave® L-Theanine supplementation for 28 days was safe and significantly decreased perceived stress and light sleep, improved sleep quality, and enhanced cognitive attention in healthy adults with moderate stress.

• Clinically Validated for Sleep Quality — A systematic review of 13 eligible trials (n = 550) demonstrated that supplementation with 200–450 mg/day of L-theanine appears to be a safe and effective way to support healthy sleep in adults, with beneficial effects on sleep latency, maintenance, efficiency, perceived sleep satisfaction, and feelings of refreshment on waking. Doses up to 900 mg daily produced no next-day drowsiness, cognitive impairment, or motor deficits.

• Clinically Validated for Cognitive Function — A meta-analysis of randomized controlled trials provides evidence that theanine plus caffeine, and theanine alone, could be beneficial for cognitive and mood outcomes.

• Unique Relaxed Alertness Mechanism — L-Theanine modulates glutamate receptors to enhance neuroprotection (BDNF upregulation, cortisol reduction), activates AMPK for anti-obesity effects (lipid oxidation, adiponectin secretion), and activates γδ T cells to bolster immunomodulation.

• Water-Soluble — Freely soluble in water; suitable for capsules, tablets, powder drink mixes, functional beverages, and liquid formulations.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated L-theanine across a range of doses. A systematic review of 13 eligible trials (n = 550) identified that supplementation with 200–450 mg/day of L-theanine appears to be a safe and effective way to support healthy sleep in adults. Clinical studies typically use L-theanine at a dosage of 100–400 milligrams per day, with most studies suggesting a daily dose of 100–400 mg. A typical split involves 100–200 mg in the morning or early afternoon, and 100–200 mg later in the day if needed for relaxation or sleep. For stress relief, 50–200 mg before a stressful event is commonly used. For sleep in ADHD, 200 mg twice a day has been used. Doses up to 900 mg daily produced no next-day drowsiness, cognitive impairment, or motor deficits across all studied populations aged 9–57 years. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.