Product Detailed Description

liposomal Fisetin 70% — High Bioavailability Senolytic Supplement

Product Overview

Liposomal Fisetin 70% is a premium-grade dietary supplement ingredient delivering fisetin in an advanced liposomal delivery system. Fisetin (CAS 528-48-3), also known as 3,3′,4′,7-tetrahydroxyflavone or 5-desoxyquercetin, is a naturally occurring flavonol polyphenol belonging to the flavonoid class of plant secondary metabolites. It is chemically characterized by the molecular formula C₁₅H₁₀O₆ and a molecular weight of 286.24 g/mol. Fisetin was first isolated from Venetian sumach in 1833 and is found in various fruits and vegetables including strawberries, apples, persimmons, grapes, and onions, with strawberries containing the highest concentration.

Fisetin exhibits a broad spectrum of pharmacological activities, including potent antioxidant, anti-inflammatory, anticancer, neuroprotective, and senolytic effects. It has been identified as a geroprotector that promotes cellular metabolism, reduces senescence, regulates sirtuin function, and may promote longevity. As a novel powerful senolytic agent, fisetin has been investigated for its ability to address aging and aging-related disorders by selectively targeting senescent cells.

Why Liposomal Technology?

Conventional fisetin presents significant formulation challenges. The compound has poor water solubility (10.45 μg/mL), high lipophilicity (LogP 3.2), and limited oral bioavailability (approximately 44.1%), which significantly restrict its pharmacological applications.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Solubility and Bioavailability — Liposomal encapsulation significantly increases the solubilizing capacity and stability of fisetin. A PEG/R8 co-modified fisetin liposome formulation achieved a Cmax of 604.05 ± 166.73 ng/mL, prolonged half-life to 5.04 ± 0.63 hours, and enhanced relative oral bioavailability to 7.71-fold compared to free fisetin. A separate liposomal formulation demonstrated a 47-fold increase in relative bioavailability compared to free fisetin.

2. Gastric Protection — The phospholipid bilayer shields fisetin from premature degradation during digestive transit, preserving its intact molecular structure until reaching optimal absorption sites in the small intestine.

3. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. Hyaluronic acid-coated nanoliposomes have been shown to improve the storage and thermal stability as well as the digestive stability and bioaccessibility of encapsulated fisetin.

4. Targeted Senescent Cell Delivery — Liposomal encapsulation facilitates targeted delivery of fisetin to senescent cells, where it exerts its senolytic effects by inhibiting anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby promoting the death of senescent cells.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% fisetin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances relative oral bioavailability up to 7.71-fold compared to free fisetin, with prolonged half-life and enhanced cellular delivery.

• Potent Senolytic Activity — Fisetin selectively targets and eliminates senescent cells by inhibiting Bcl-2 and Bcl-xL, reducing the senescence-associated secretory phenotype (SASP) and age-related inflammation.

• Clinically Validated for Senolytic Dosing — A Phase I/II randomized clinical trial in knee osteoarthritis patients used oral fisetin at 20 mg/kg body weight for 2 consecutive days per cycle, with 3 cycles over 12 months.

• Anti-Aging and Longevity Support — Preclinical studies demonstrate that intermittent fisetin supplementation improves physical function, reduces frailty, and decreases cellular senescence in skeletal muscle with aging.

• Neuroprotective and Cognitive Support — Fisetin exerts neuroprotective effects through modulation of key cellular pathways, including mTOR, Wnt/β-catenin, and NF-κB signaling.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated fisetin across a range of dosing protocols. A Phase I/II randomized, double-blind, placebo-controlled clinical trial in individuals aged 40–80 with radiographically confirmed knee osteoarthritis used oral fisetin at 20 mg/kg body weight for 2 consecutive days, followed by 28 days off, for 3 dosing cycles over a 12-month study period. A low-dose fisetin study in middle-aged and older adults used 100 mg of oral fisetin once daily for 7 weeks for chronic inflammation support. For general senolytic and healthy aging support, the "hit-and-run" dosing strategy—20 mg/kg for 2 consecutive days per month—is commonly used in clinical research. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.