Product Detailed Description

liposomal GHK-CU 70% — High Bioavailability Copper Peptide Supplement

Product Overview

Liposomal GHK-Cu 70% is a premium-grade dietary supplement ingredient delivering GHK-Cu in an advanced liposomal delivery system. GHK-Cu (CAS 89030-95-5), also known as copper tripeptide-1, is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) complexed with copper(II). It is chemically characterized by the molecular formula C₁₄H₂₂CuN₆O₄ and a molecular weight of 401.91 g/mol. GHK-Cu was first isolated from human plasma by Pickart in 1973 and is also found in saliva and urine.

GHK has an extremely high affinity for copper(II), with a pK for the dissociation constant of approximately 16—similar to the copper transport site on albumin. This high-affinity binding forms a stable complex that possesses significant superoxide dismutase-like activity, with a rate constant of about 25% of the activity of enzymatic Cu,Zn-superoxide dismutase. GHK-Cu exhibits diverse biological activities, including skin-repairing, skin-remodeling, anti-aging, anti-inflammatory, and antioxidant properties.

Why Liposomal Technology?

Conventional GHK-Cu presents significant formulation challenges. GHK-Cu is a fairly hydrophilic compound with limited permeation through the lipophilic stratum corneum. The peptide is susceptible to enzymatic degradation by carboxypeptidases found in wound environments and plasma, which rapidly reduces the amount of active peptide reaching the target tissue. These limitations significantly restrict the efficacy of conventional GHK-Cu formulations.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability and Anti-Enzymatic Degradation — The phospholipid bilayer shields GHK-Cu from enzymatic degradation by carboxypeptidases, preserving its intact molecular structure during digestive transit and topical application. The rigid-flexible nanocarrier system demonstrates a favorable ability for anti-enzymatic degradation and skin penetration.

2. Enhanced Skin Permeation — liposomes capable of encapsulating GHK-Cu may improve its permeation potential through the lipophilic stratum corneum. The transport of liposomes containing GHK-Cu has been shown to enhance skin permeation, with studies demonstrating that cell-penetrating peptides further enhance skin absorption of GHK-Cu.

3. Enhanced Cellular Uptake — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. Liposomes can be used as carriers for biomimetic peptides such as GHK-Cu, with GHK-Cu loaded liposomes demonstrating excellent antioxidant and anti-inflammatory capacity.

4. Targeted Delivery to Skin and Connective Tissues — Liposomal encapsulation facilitates targeted delivery of GHK-Cu to fibroblasts and other connective tissue cells, where it exerts its collagen-stimulating and tissue-remodeling effects.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% GHK-Cu by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects GHK-Cu from enzymatic degradation and enhances skin permeation through the lipophilic stratum corneum.

• Collagen and Elastin Synthesis — GHK-Cu stimulates collagen synthesis in fibroblast cultures and increases protein synthesis of collagen and elastin. The presence of a GHK triplet in the α2(I) chain of type I collagen suggests that the tripeptide may be liberated by proteases at the site of a wound and exert in situ healing effects.

• Matrix Remodeling — GHK-Cu stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan decorin.

• Clinically Validated for Photoaging — A randomized controlled trial in 67 women with photoaging demonstrated that GHK-Cu cream over 12 weeks improved fine lines and skin density versus placebo.

• Hair Growth Support — A 2026 randomized, double-blind, vehicle-controlled split-face study in 18 healthy participants reported that a 2% GHK-Cu serum improved eyebrow hair count and diameter over 12 weeks without serious adverse effects.

• Wound Healing Support — A Phase 2 randomized, double-blind, vehicle-controlled split-wound study is evaluating topical GHK-Cu gel to accelerate re-epithelialization of standardized acute skin wounds in healthy adults.

• Antioxidant Activity — GHK-Cu possesses significant superoxide dismutase-like activity, scavenging reactive oxygen species and protecting cells from oxidative damage.

• Elastase Inhibition — GHK-Cu has been shown to lead to 48.90 ± 2.50% elastase inhibition, supporting skin elasticity and anti-aging.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated GHK-Cu across a range of concentrations and delivery formats. A randomized controlled trial in 67 women with photoaging used GHK-Cu cream over 12 weeks. A 2026 split-face study in 18 healthy participants used a 2% GHK-Cu serum, demonstrating improvement in eyebrow hair count and diameter over 12 weeks without serious adverse effects. A cream combining 5% ferment extract and 0.2% GHK-Cu was evaluated for skin protection and anti-aging effects. For general skin and hair support, 1–5 mg daily is commonly used in oral formulations. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability. GHK-Cu exhibits a biphasic dose response—concentrations that stimulate at low levels can be cytotoxic at high ones, so appropriate dosing is essential.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.