Product Detailed Description

Liposomal azelaic acid 70% — High Bioavailability Sebum-Regulating and Skin-Brightening Supplement

Product Overview

liposomal Azelaic Acid 70% is a premium-grade dietary supplement ingredient delivering azelaic acid in an advanced liposomal delivery system. Azelaic acid (CAS 123-99-9), also known as nonanedioic acid or 1,7-heptanedicarboxylic acid, is a saturated dicarboxylic acid with the molecular formula C₉H₁₆O₄ and a molecular weight of 188.22 g/mol. It is chemically characterized as HOOC(CH₂)₇COOH. Azelaic acid occurs as a white to slightly yellowish crystalline powder or needles and is practically insoluble in cold water, but soluble in hot water, ethanol, and organic solvents.

Azelaic acid is a naturally occurring dicarboxylic acid produced by the ozonolysis of oleic acid and is also found in wheat, barley, and rye. It exhibits a broad spectrum of dermatological activities including keratolytic, comedolytic, antimicrobial, and anti-inflammatory effects. It is an FDA-approved active ingredient for topical treatment of acne (20% cream, Azelex, approved 1995) and rosacea (15% gel/foam, Finacea). Azelaic acid is also used for hyperpigmentation disorders including melasma and post-inflammatory hyperpigmentation.

The 70% specification represents the active ingredient loading capacity by weight relative to the total liposomal formulation, providing a highly concentrated yet stable delivery system for this versatile dicarboxylic acid.

Why Liposomal Technology?

Conventional azelaic acid presents significant formulation and bioavailability challenges. The compound has limited aqueous solubility (2.4 g/L at 20°C) and inadequate penetration across the stratum corneum, which might be related to different possible side effects such as itching and burning. Additionally, azelaic acid has poor absorption through the skin, thus requiring repeated and prolonged application in conventional formulations.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Encapsulation Efficiency and Stability — Liposomal formulations prepared by the lipid film hydration method with different concentrations of azelaic acid (15%, 20%, 25%) achieved 80.42% encapsulation efficiency, with a size of up to 500 nm and good stability, as demonstrated by FTIR spectroscopy, DLS, and zeta-potential measurements. The optimum formulation in terms of both antimicrobial and wound healing effect was ALAipo20% (liposomes with 20% azelaic acid included).

2. Enhanced Antimicrobial Activity — All liposomal formulations exhibited a better antibacterial effect compared to free azelaic acid solution against Staphylococcus aureus and Enterococcus faecalis. This enhanced antimicrobial activity is particularly relevant for acne management, where Cutibacterium acnes (formerly Propionibacterium acnes) plays a key pathogenic role.

3. Enhanced Wound Healing and Cytoprotection — Cytotoxicity assays and an in vitro "scratch" test performed with normal human dermal fibroblasts revealed an accelerating healing effect, while a comet assay evidenced the protective effect of azelaic acid liposomal formulations against hydrogen peroxide-induced DNA damage in fibroblasts. These findings support the enhanced biocompatibility and cytoprotective properties of liposomal azelaic acid.

4. Enhanced Skin Penetration and Bioavailability — Liposome encapsulation enhances azelaic acid's benefits by providing deeper skin penetration and effective delivery. Liposomal technology has been incorporated into azelaic acid preparations where its efficacy and better bioavailability of the active ingredient have been proven.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% azelaic acid in the liposomal formulation, with ≥99% (HPLC) assay available.

• Liposomal Enhancement — Lipid film hydration method achieves 80.42% encapsulation efficiency with particle sizes up to 500 nm and good stability confirmed by FTIR, DLS, and zeta-potential measurements.

• Enhanced Antimicrobial Activity — Liposomal formulations exhibit better antibacterial activity against Staphylococcus aureus and Enterococcus faecalis compared to free azelaic acid solution.

• Wound Healing and Cytoprotection — Demonstrates an accelerating healing effect in human dermal fibroblasts and protective effect against hydrogen peroxide-induced DNA damage.

• FDA-Approved for Acne and Rosacea — Azelaic acid is an FDA-approved active ingredient for topical treatment of acne (20% cream) and rosacea (15% gel/foam).

• Keratolytic and Comedolytic — Exerts keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and the amount and distribution of filaggrin in epidermal layers.

• Anti-Inflammatory Activity — Possesses direct anti-inflammatory effect due to scavenger activity of free oxygen radicals and modulation of the inflammatory response through PPARγ activation.

• Melanin Synthesis Inhibition — Inhibits tyrosinase activity and melanin synthesis, making it effective for hyperpigmentation disorders including melasma and post-inflammatory hyperpigmentation.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

For topical applications, azelaic acid is FDA-approved at 20% (cream, for acne) and 15% (gel/foam, for rosacea), typically applied twice daily (morning and evening). Improvement is usually detectable within 1–2 months of initiating therapy. For oral supplementation with liposomal azelaic acid, 100–500 mg per day is commonly used, depending on the intended application. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and skin penetration. Individual sensitivity varies, and it is advisable to start with a lower dose and gradually increase as tolerated.

Important Safety Information: Azelaic acid is generally well tolerated. The most common side effects are local skin reactions including itching, burning, stinging, erythema, and dryness at the application site. These reactions are typically mild and transient. Individuals with known hypersensitivity to azelaic acid or related compounds should avoid use. Pregnant or lactating women and children should consult a healthcare professional before use. Azelaic acid may interact with certain medications; consult a healthcare professional if taking prescription drugs.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.