Product Detailed Description

Liposomal calcium lactate 80% — High Bioavailability Gentle Calcium Supplement

Product Overview

liposomal Calcium Lactate 80% is a premium-grade dietary supplement ingredient delivering calcium lactate in an advanced liposomal delivery system. Calcium lactate (CAS 814-80-2), also known as calcium 2-hydroxypropanoate or calcium dilactate, is the calcium salt of lactic acid, chemically characterized by the molecular formula C₆H₁₀CaO₆ (anhydrous) and a molecular weight of 218.22 g/mol. It is a white, nearly odorless, crystalline powder or granule that is soluble in water (solubility approximately 9 g/100 mL at 25°C) and practically insoluble in ethanol. Calcium lactate provides approximately 13.1%–14.5% elemental calcium and is a food additive with the European E number E327 and INS number 327, functioning as an acidity regulator, antioxidant, emulsifier, firming agent, stabilizer, and thickener.

Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth as hydroxyapatite complexes. The remaining 1% of "non-bone calcium" plays critical roles in muscle contraction, nerve impulse transmission, blood clotting, and hormone secretion. Calcium lactate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability, excellent water solubility, neutral taste, and superior gastrointestinal tolerability.

Why Liposomal Technology?

Calcium lactate already offers superior bioavailability compared to calcium carbonate, with a solubility of approximately 5% (w/v) and excellent absorption and body absorption properties without known side effects. However, conventional calcium lactate still faces limitations related to the regulated nature of intestinal calcium transport, interactions with dietary inhibitors, and the potential for gastrointestinal discomfort at higher doses.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability and Targeted Delivery — liposomes protect active ingredients from being destroyed by gastric acid and digestive enzymes. A preclinical study demonstrated that calcium lactate nanoliposomes achieved an encapsulation efficiency of 93.42% with a particle size of 172.1 nm and a zeta potential of −53.45 mV, demonstrating excellent colloidal stability. Encapsulation within liposomal vesicles enhanced calcium delivery to target cells, increasing intracellular calcium and stimulating downstream physiological responses.

2. Protection from Dietary Inhibitors — The phospholipid bilayer shields calcium from binding with oxalates or phytates in the diet, which normally block absorption.

3. Enhanced Stability and Slow Release — The phospholipid layer acts as a protective shell, effectively preventing active ingredients from degrading due to light, oxidation, or pH changes. The nanoliposomes demonstrated stable pH and particle size over six cycles.

4. Gentle on the Gastrointestinal Tract — Calcium lactate is known for its low gastrointestinal irritation and neutral taste. Liposomal encapsulation further minimizes direct contact between calcium and the gastrointestinal mucosa, reducing the risk of bloating and constipation associated with traditional calcium salts.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% calcium lactate, with elemental calcium content of 13.1%–14.5% (anhydrous basis).

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 93.42% encapsulation efficiency with 172.1 nm particle size, protecting calcium from gastric degradation and dietary inhibitors and enhancing cellular delivery.

• Superior Bioavailability — Calcium lactate has excellent bioavailability and body absorption properties, with high water solubility (approximately 9 g/100 mL at 25°C) and no known side effects.

• GRAS and FDA Affirmed — Calcium lactate is Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1207 for use as a direct human food ingredient with no limitation other than current good manufacturing practice.

• Neutral Taste Profile — Calcium lactate has a neutral taste and nearly odorless character, making it ideal for beverages and oral formulations.

• Gentle on the Stomach — Calcium lactate features low gastrointestinal irritation and does not require gastric acid for dissolution, making it suitable for individuals with sensitive stomachs or low gastric acid output.

• Clinically Established for Calcium Deficiency — Calcium lactate is indicated for the treatment of calcium deficiency states as a therapeutic supplement in pregnancy, lactation, osteoporosis, post-gastrectomy malabsorption, osteomalacia, and rickets.

• Water-Dispersible — Freely soluble in water; suitable for capsules, tablets, powder drink mixes, functional beverages, and food fortification applications.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical guidelines for calcium lactate recommend 300–600 mg per day for adults including the elderly (1–2 tablets daily). Pregnant women during the third trimester and lactation should take 0.9–1.2 g daily (3–4 tablets). Children over 3 years may take 300 mg daily (one tablet). The Recommended Dietary Allowance (RDA) for elemental calcium is 1,000 mg/day for adults aged 18–50 years, 1,000 mg/day for males aged 51–70 years, and 1,200 mg/day for females aged 51–70 years and all adults aged 71 years and older. The Tolerable Upper Intake Level (UL) for elemental calcium is 2,500 mg/day for adults aged 19–50 years and 2,000 mg/day for adults aged 51 years and older. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.