Product Detailed Description

liposomal Potassium Azeloycinate Diglycinate 70% — High Bioavailability Sebum-Regulating and Skin-Brightening Supplement

Product Overview

Liposomal Potassium Azeloycinate Diglycinate 70% is a premium-grade dietary supplement ingredient delivering potassium azeloyl diglycinate (PAD) in an advanced liposomal delivery system. Potassium azeloyl diglycinate (CAS 477773-67-4), also known as PAD, Azeloglicina, or potassium hydrogen heptylenedicarboxamidodiacetate, is the monopotassium salt of N,N'-(1,9-dioxo-1,9-nonanediyl)bis-glycine. It is chemically characterized by the molecular formula C₁₃H₂₁KN₂O₆ and a molecular weight of 340.41 g/mol. PAD is a water-soluble azelaic acid derivative formed by the neutralization of azelaic acid with glycine, typically supplied as a colorless to light yellow transparent liquid or a white to off-white powder.

PAD is a highly efficient modified form of azelaic acid, combining the oil control, anti-inflammatory, and whitening effects of azelaic acid with the moisturizing and soothing effects of glycine. Its excellent water solubility and low irritation make it a mild functional ingredient that can be used for sensitive skin, making it an "upgraded version" of azelaic acid. PAD has demonstrated sebostatic and whitening activities, inhibiting sebum secretion and melanin production while helping to even out skin tone and lighten spots.

Why Liposomal Technology?

Conventional PAD, while already offering superior water solubility and tolerability compared to azelaic acid, can be further enhanced through liposomal encapsulation. Liposomal delivery systems provide an additional protective layer that enhances skin penetration and facilitates efficient cellular delivery.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Skin Penetration and Delivery — Liposomal encapsulation utilizes phospholipid-based carrier technology to enhance the percutaneous absorption of PAD. The liposomal bilayer mimics cell membrane structure, facilitating fusion with skin cells and efficient delivery of PAD to the target layers. This complements PAD's inherent water solubility and improves its bioavailability at the site of action.

2. Protection from Degradation — The phospholipid bilayer shields PAD from oxidative degradation and premature breakdown during storage and application, preserving its intact molecular structure until reaching target cells. PAD is known for strong stability and is not easy to oxidize, and liposomal encapsulation further extends this stability profile.

3. Reduced Irritation Potential — PAD is already recognized for its low irritation and suitability for sensitive skin. Liposomal encapsulation further minimizes direct contact between PAD and the skin surface, reducing the risk of the stinging sensation that can occur with azelaic acid and its derivatives, and improving tolerability for fragile or compromised skin.

4. Sustained Release for Prolonged Activity — Liposomal delivery provides a controlled-release profile that maintains steady levels of PAD at the target site, supporting prolonged sebum-regulating and skin-brightening activity rather than a sharp peak followed by rapid decline.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% potassium azeloyl diglycinate by HPLC, with ≥98% assay available for premium applications.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances skin penetration, protects from oxidative degradation, and provides sustained release for prolonged activity.

• Superior Water Solubility — PAD is completely soluble in water, unlike azelaic acid, making it easy to formulate and apply in a wide range of product formats.

• Sebum-Regulating and Anti-Acne — Inhibits sebum secretion, tightens pores, and effectively improves acne, blackheads, and pimples caused by excessive oil.

• Mild Whitening and Spot Reduction — By inhibiting tyrosinase activity and melanin production, PAD helps to even out skin tone and lighten spots and acne marks.

• Anti-Inflammatory and Soothing — Reduces acne inflammation and redness, suitable for soothing formulas for sensitive and acne-prone skin.

• High Safety and Low Irritation — Suitable for sensitive skin, with excellent water solubility and low irritation making it a mild functional ingredient.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend varying doses of PAD depending on the application. For topical formulations, the general recommended addition amount is 2–8%, with suggested adding amounts of 2–15% for drench and 2–10% for residual formulations. PAD powder is water-soluble, requires a lower dosage than azelaic acid, and has a strong anti-inflammatory effect. For oral supplementation, 100–500 mg per day is commonly used, depending on the intended application and formulation. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.