Product Detailed Description

Liposomal calcium lactate Gluconate 80% — High Bioavailability Bone Health Supplement

Product Overview

Liposomal calcium lactate gluconate 80% is a premium-grade dietary supplement ingredient delivering calcium lactate gluconate in an advanced liposomal delivery system. Calcium lactate gluconate (CAS 11116-97-5) is a water-soluble calcium complex formed from two molecules of calcium gluconate and three molecules of calcium lactate, chemically characterized by the molecular formula Ca₃(C₃H₅O₃)₆(C₆H₁₁O₇)₄·2H₂O and a molecular weight of 1551.4. Approximately 7.74 grams of calcium lactate gluconate (dihydrate) yields the equivalent of one gram of elemental calcium.

Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth as hydroxyapatite complexes. The remaining 1% of "non-bone calcium" plays critical roles in muscle contraction, nerve impulse transmission, blood clotting, and hormone secretion. Calcium lactate gluconate is recognized as one of the most intensively researched organic calcium salts with regard to bioavailability, demonstrating superior effects on fractional absorption rate of calcium and bone mineral density.

Why Liposomal Technology?

Calcium lactate gluconate already offers superior bioavailability compared to calcium carbonate, with its high water solubility attributed to the presence of lactate and gluconate anions. However, even highly soluble calcium salts face absorption challenges related to saturable intestinal transport systems and interactions with dietary inhibitors.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability and Absorption — A randomized crossover human absorption study evaluated solid-state liposomal calcium versus non-liposomal calcium over an 8-hour period. Solid-state liposomal calcium significantly increased blood calcium levels at early time points (1–2 h; p < 0.05) and maintained elevated levels up to 8 hours post-administration. The AUC was 2.94 mg·h/dL for the liposomal group versus 1.88 mg·h/dL for the non-liposomal group, representing a 1.56-fold increase in systemic calcium exposure.

2. Protection from Dietary Inhibitors — The phospholipid bilayer shields calcium from binding with oxalates or phytates in the diet, which normally block absorption. liposomes protect active ingredients from being destroyed by gastric acid and digestive enzymes.

3. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. Due to their affinity with cell membranes, active substances can penetrate the intestinal wall more efficiently and enter the bloodstream and cells directly.

4. Gentle on the Gastrointestinal Tract — Liposomal encapsulation minimizes direct contact between calcium and the gastrointestinal mucosa, reducing the risk of bloating and constipation associated with traditional calcium salts.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% calcium lactate gluconate, with elemental calcium content of 12.92% and assay of 96.0%–102.0% (TGA specification).

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves a 1.56-fold increase in systemic calcium exposure compared to non-liposomal calcium in human absorption study.

• Superior Bioavailability — Calcium lactate gluconate is among the most intensively researched organic calcium salts with regard to bioavailability, demonstrating a superior effect on fractional absorption rate of calcium.

• Clinically Validated for Bone Density — A meta-analysis of 16 clinical studies in elderly and late postmenopausal women demonstrated that calcium lactate gluconate supplementation increased BMD of the lumbar spine between +0.2 to +1.8%, whereas other supplements partly decreased BMD.

• GRAS and FDA Affirmed — Calcium lactate gluconate has GRAS (Generally Recognized As Safe) status under FDA with a low order of toxicity.

• Gentle on the Stomach — Liposomal encapsulation minimizes direct contact between calcium and the gastrointestinal mucosa, and calcium lactate gluconate is highly water-soluble and well-absorbed.

• Water-Dispersible — High water solubility attributed to the presence of lactate and gluconate anions; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

According to the International Osteoporosis Foundation, the recommended daily calcium intake for both women and men aged 19 to 50 years is 1,000 mg, increasing to 1,200 mg from age 51 in women and after 70 in men. Clinical trials using calcium lactate gluconate for bone health have used 500–1,250 mg/day of calcium for 12–48 months. A meta-analysis of 16 clinical studies in elderly and late postmenopausal women compared supplementation with 500–1,250 mg/day calcium as calcium lactate gluconate, calcium carbonate, calcium citrate, and other salts for 12–48 months. The Tolerable Upper Intake Level (UL) for calcium is 2,000–2,500 mg per day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.