Product Detailed Description

Liposomal copper gluconate 80% — High Bioavailability Trace Mineral Supplement

Product Overview

liposomal Copper Gluconate 80% is a premium-grade dietary supplement ingredient delivering copper gluconate in an advanced liposomal delivery system. Copper gluconate (CAS 527-09-3), also known as cupric gluconate or copper(II) D-gluconate, is an organic copper salt formed by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. It is chemically characterized by the molecular formula C₁₂H₂₂CuO₁₄ and a molecular weight of 453.84 g/mol. Copper gluconate occurs as light blue to bluish-green, odorless crystals, or as a fine, light blue powder, and is freely soluble in water.

Copper is an essential trace mineral present in all body tissues, with the highest concentrations found in the liver, brain, heart, and kidneys. It serves as a critical cofactor for a diverse array of enzymes that are fundamental to human physiology. Copper gluconate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability, excellent water solubility, and superior gastrointestinal tolerability compared to inorganic copper salts.

Why Liposomal Technology?

Copper gluconate already offers superior bioavailability and water solubility compared to inorganic copper salts. However, conventional copper formulations still face challenges related to the saturable nature of intestinal copper transport and interactions with competing minerals.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability and Absorption — Liposomal encapsulation improves mineral absorption 4–6× vs standard mineral powders. The liposomal delivery system protects copper from premature interaction with dietary inhibitors such as zinc and molybdenum, which compete for the same intestinal transport pathways.

2. Reduced Gastrointestinal Irritation — Liposomal encapsulation minimizes direct contact between copper and the gastrointestinal mucosa, reducing the risk of nausea and gastric discomfort commonly associated with conventional copper salts. The liposomal form is gentle on the stomach, highly absorbable, and bioavailable, making it suitable for individuals with sensitive stomachs.

3. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This mechanism complements the high-affinity copper transporter 1 (Ctrl) and ATP7A pathways utilized by free copper, supporting enhanced systemic absorption and intracellular delivery to copper-dependent enzymes.

4. Controlled Release — Liposomal formulations provide sustained release of copper, maintaining consistent active levels for prolonged enzymatic support and reducing the risk of rapid biliary excretion. Copper is primarily excreted through bile and feces, and sustained release supports more efficient utilization of the trace mineral.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% copper gluconate, with elemental copper content of 13.7%–14.3% (USP/FCC) and assay of 98.0%–102.0%.

• Liposomal Enhancement — Phospholipid bilayer encapsulation improves mineral absorption 4–6× compared to standard mineral powders, protects copper from gastric degradation and dietary inhibitors, and enhances cellular delivery through lipid-mediated pathways.

• GRAS and FDA Affirmed — Copper gluconate is Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1260 for use as a nutrient supplement and synergist in food, with no limitation other than current good manufacturing practice.

• Essential Enzyme Cofactor — Copper is a critical cofactor for cytochrome c oxidase (mitochondrial energy production), superoxide dismutase (antioxidant defense), ceruloplasmin (iron metabolism), and lysyl oxidase (collagen and elastin cross-linking).

• Iron Metabolism Support — Copper is required for the oxidation of iron to the Fe³⁺ state for transport by transferrin. Copper deficiency impairs iron mobilization, leading to anemia.

• Antioxidant Defense — Copper-zinc superoxide dismutase (CuZnSOD) is a copper-dependent enzyme that protects cells from oxidative damage by catalyzing the dismutation of superoxide radicals.

• Gentle on the Stomach — Copper gluconate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability and excellent gastrointestinal tolerability.

• Water-Dispersible — Freely soluble in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Copper gluconate is the preferred supplement for copper deficiency. Supplemental doses of elemental copper effective in several copper depletion/repletion experiments ranged from 2 to 6 mg daily. Replacement with 2 mg of elemental copper 2–3 times a day orally is the preferred method of copper replacement. Commercial copper gluconate supplements typically provide 2 mg elemental copper per tablet with a suggested intake of one tablet daily. The Tolerable Upper Intake Level (UL) for copper is 10 mg daily for adults. Copper intake should be balanced with zinc intake, as excessive zinc can interfere with copper absorption. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–7 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.