Product Detailed Description

Liposomal Curcumin 70% — High Bioavailability Turmeric Extract Supplement

Product Overview

liposomal Curcumin 70% is a premium-grade dietary supplement ingredient delivering curcumin in an advanced liposomal delivery system. Curcumin (diferuloylmethane or curcumin I) is the principal curcuminoid of turmeric, a perennial rhizomatous plant of the Zingiberaceae family native to tropical and subtropical regions. The three major chemical components of turmeric—curcumin, demethoxycurcumin, and bisdemethoxycurcumin—are collectively referred to as curcuminoids, with curcumin being the most abundant and biologically active constituent.

Curcumin has been extensively studied for its broad-spectrum pharmacological activities, including anti-inflammatory, antioxidant, anticancer, neuroprotective, and immunomodulatory effects. It modulates key signaling pathways such as NF-κB, NLRP3 inflammasome, and Nrf2, contributing to its diverse therapeutic potential. However, its clinical utility is severely limited by poor oral bioavailability. Liposomal encapsulation addresses this challenge by protecting curcumin from degradation and enhancing its delivery to target cells.

Why Liposomal Technology?

Curcumin presents significant formulation challenges. The compound is practically insoluble in water, degrades rapidly under alkaline conditions, and undergoes extensive first-pass metabolism in the intestine and liver. Following oral administration of conventional curcumin, the vast majority is metabolized by intestinal flora or excreted before absorption, with only a small fraction reaching systemic circulation. Native curcumin exhibits poor intestinal permeability, and its low solubility further limits absorption.

Liposomal encapsulation provides three critical advantages:

1. Solubility and Stability Enhancement — By encapsulating curcumin within a sunflower phospholipid bilayer, its solubility and stability are significantly improved. The encapsulation of liposomes forms an independent nanoparticle that can increase the solubility of curcumin in water while protecting it from external environmental factors including light, heat, and oxidation. The liposomal membrane shields curcumin from enzymatic degradation in the gastrointestinal tract, preserving its intact molecular structure until reaching target cells.

2. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. In a human clinical trial, liposomal curcumin achieved a maximum plasma concentration of 423 ng/mL versus 34 ng/mL for free curcumin, confirming substantially improved systemic exposure.

3. Superior Bioavailability — A randomized, double-blind, clinical trial compared a novel double-layered nano-liposomal curcumin (BNT–C060) versus conventional free curcumin in healthy male volunteers. The liposomal formulation demonstrated 23.2-fold higher dose-normalized plasma AUC₀–ₜ (5.00 vs. 0.22 ng·h/mL/mg), 53-fold higher Cmax (1.06 vs. 0.02 ng/mL/mg), and 35.3-fold higher urinary exposure. Tmax was also significantly earlier (0.86 vs. 3.3 h), indicating faster absorption. A single oral dose of the liposomal formulation was generally well tolerated within the evaluated dose range, with no clinically significant safety signals observed.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% curcumin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Sunflower phospholipid bilayer encapsulation achieves encapsulation efficiency of approximately 86% with particle size of 100–120 nm and zeta potential of −31 to −55 mV.

• Human Clinical Validation — Randomized, double-blind clinical trial demonstrated 23.2-fold higher plasma AUC₀–ₜ, 53-fold higher Cmax, and 35.3-fold higher urinary exposure compared to free curcumin.

• Superior Plasma Concentration — Liposomal curcumin achieved Cmax of 423 ng/mL versus 34 ng/mL for free curcumin in human pharmacokinetic study.

• Faster Absorption — Tmax of 0.86 h versus 3.3 h for free curcumin, indicating significantly faster onset of action.

• Anti-Inflammatory Mechanisms — Curcumin inhibits NF-κB signaling, reduces mitochondrial ROS generation, and suppresses NLRP3 inflammasome activation.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Clean-Label Compatible — Non-GMO sunflower phospholipid carrier; no synthetic excipients.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated liposomal curcumin across a range of doses. A randomized controlled trial in patients undergoing total laparoscopic hysterectomy used 50 mg oral liposomal curcumin twice daily, starting on preoperative day 1 and continuing for 2 postoperative days, demonstrating significantly lower postoperative 24-hour VAS scores (1.0 ± 0.4 vs 1.8 ± 1.1 for placebo; p = 0.007) and higher quality of recovery scores (112.4 ± 2.2 vs 105.6 ± 5.8; p < 0.001). A Phase I/II study evaluating intravenous liposomal curcumin in combination with standard radiation and temozolomide in patients with newly diagnosed high-grade gliomas used weekly doses of 300, 350, and 400 mg/m². For general antioxidant and anti-inflammatory support, 200–500 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.