Product Detailed Description

Liposomal PQQ 70% — High Bioavailability Mitochondrial Energy Supplement

Product Overview

liposomal PQQ 70% is a premium-grade dietary supplement ingredient delivering pyrroloquinoline quinone (PQQ) in an advanced liposomal delivery system. PQQ (CAS 72909-34-3), also known as methoxatin, is a water-soluble, vitamin-like redox-cycling orthoquinone initially isolated from cultures of methylotropic bacteria. It is a tricyclic ortho-quinone having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups, with the molecular formula C₁₄H₆N₂O₈ and a molecular weight of 330.21 g/mol.

PQQ functions as a redox cofactor and an anionic redox-cycling protoquinone. Animal studies have demonstrated that insufficient dietary intake of PQQ can lead to notable deficits, including impaired growth and compromised reproductive outcomes. PQQ has been recognized for its neuroprotective effects in several in vitro and in vivo models of brain injury and disease, rendering it an attractive compound for treatment strategies targeting various neurological disorders.

Why Liposomal Technology?

Conventional PQQ faces formulation challenges including variable absorption and limited cellular delivery. While the disodium salt form of PQQ demonstrates improved solubility compared to the free acid, optimized delivery systems are required to maximize bioavailability and target tissue distribution.

Liposomal encapsulation provides three critical advantages:

1. Digestive Protection — The phospholipid bilayer shields PQQ from degradation during digestive transit, preserving its intact molecular structure until reaching optimal absorption sites. The incorporation of PQQ into liposomes and its interactions with lipids have been shown to enhance formulation stability for up to four weeks and allow sustained release for seven weeks.

2. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. Small-size liposomes have excellent absorbability, and liposomal encapsulation enables extension of the optimum concentration range in which the distinctive function of PQQ is exhibited.

3. Sustained Release — Liposomal PQQ formulations exhibit biphasic release behavior, initially driven by the gradient of non-encapsulated PQQ followed by a sustained release of encapsulated PQQ. Optimized formulations with higher cholesterol content demonstrate gradual liberation profiles, with up to 90.3% of PQQ released over 7 weeks.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% PQQ by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects PQQ during digestive transit, enhances cellular uptake, and provides sustained release with biphasic kinetics.

• Mitochondrial Biogenesis — PQQ stimulates mitochondrial biogenesis through activation of the SIRT1/PGC-1α signaling pathway, promoting new mitochondria formation and enhancing cellular energy capacity.

• Neuroprotective Effects — PQQ reduces oxidative stress and inflammation via Nrf2 activation and NF-κB inhibition. It alleviates cognitive decline and neurological injury in preclinical studies and improves folate transport in cerebral folate deficiency.

• Clinically Validated for Cognition — A randomized, double-blind, placebo-controlled trial in elderly individuals with mild cognitive impairment demonstrated that PQQ supplementation significantly elevated serum BDNF levels and improved cognitive function indices.

• Antioxidant Defense — PQQ is a potent antioxidant that scavenges reactive oxygen species and protects mitochondria from oxidative damage. It blocks the formation of inducible nitric oxide synthase (iNOS), a major source of reactive nitrogen species.

• Water-Soluble — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and regulatory guidelines commonly recommend 10–20 mg of PQQ per day. The baseline intake level of PQQ is considered to be 20 mg/day, which is at least 250 times higher than the estimated background intake of PQQ naturally occurring in food. Mitsubishi Gas Chemical Company, in its FDA NDI notification, recommended a daily intake of 20 mg/day with a maximum suggested intake of 50 mg/day. PQQ disodium salt is intended to be used in foods at a maximum level of 20 mg PQQ disodium salt per serving. For chronic inflammatory conditions, 5–10 mg daily reduces circulating inflammatory cytokines; cognitive health optimization requires 10–20 mg daily; and metabolic support for mitochondrial function reaches optimal efficacy at approximately 20 mg daily. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.