Liposomal Inositol 80% — High Bioavailability PCOS and Mood Support Supplement

Product Overview

liposomal Inositol 80% is a premium-grade dietary supplement ingredient delivering myo-inositol in an advanced liposomal delivery system. Myo-inositol (CAS 87-89-8), also known as cis-1,2,3,5-trans-4,6-cyclohexanehexol, is a naturally occurring sugar alcohol and a member of the vitamin B complex family. It is chemically characterized by the molecular formula C₆H₁₂O₆ and a molecular weight of 180.16 g/mol. Myo-inositol is a white crystalline powder that is optically inactive, stable in air, and freely soluble in water (1 g in 6 mL).

Myo-inositol is the most abundant form of inositol in nature and mammalian cells, comprising up to 99% of total inositol content. It is a precursor for phosphatidylinositol (PI), a key membrane phospholipid that, upon cellular stimulation, is cleaved into second messengers such as inositol triphosphate (IP₃) and diacylglycerol (DAG). These second messengers regulate intracellular calcium levels and activate protein kinase cascades, influencing cell growth, secretion, and metabolic activity. This pathway is particularly critical in insulin signal transduction and ovarian function regulation.

Why Liposomal Technology?

Conventional inositol presents significant formulation challenges. The compound has a large effective dose requirement (typically 4 g/day for PCOS management), is rapidly cleared by the kidneys, and exhibits limited passive diffusion across intestinal membranes. These factors limit its practical utility and clinical efficacy.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Intestinal Absorption — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways and bypassing passive diffusion limitations. This complements the sodium-dependent myo-inositol transporter (SMIT1) utilized by free inositol, supporting enhanced systemic absorption.

2. Sustained Release — Liposomal formulations provide controlled release of inositol, maintaining consistent active levels for prolonged cellular signaling support and reducing the dosing frequency required for therapeutic efficacy.

3. Reduced Renal Clearance — The phospholipid bilayer protects inositol from rapid renal filtration and excretion, extending its circulation time and improving bioavailability.

4. Clinically Validated Metabolic and Reproductive Benefits — Clinical trials demonstrate that inositol supplementation improves insulin sensitivity, reduces androgen levels, and restores ovulation in women with PCOS. The combination of myo-inositol (2 g) plus D-chiro-inositol (50 mg) twice daily significantly improved menstrual cyclicity in 64.6% of PCOS patients in a 12-week randomized controlled trial.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% myo-inositol by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects inositol from rapid renal clearance and enhances intestinal absorption through lipid-mediated pathways.

• PCOS Management Support — Clinical trials demonstrate that inositol supplementation improves insulin sensitivity, reduces testosterone levels, and restores ovulation in women with PCOS. A 12-week RCT showed 64.6% of PCOS patients achieved menstrual cyclicity improvement with inositol supplementation.

• Insulin Sensitivity — Myo-inositol serves as a precursor for inositol phosphoglycans (IPGs), which act as second messengers in insulin signaling. Research shows inositol improves insulin sensitivity at the cellular level.

• Mood and Anxiety Support — Inositol is involved in serotonin neurotransmitter metabolism. Research suggests it may help balance serotonin levels, supporting mood regulation and reducing symptoms of anxiety and depression.

• Ovarian Function — Clinical studies demonstrate that myo-inositol administration to PCOS patients resulted in decreased circulating insulin and serum total testosterone levels, with restored ovulation.

• Water-Dispersible — Soluble in water (1 g in 6 mL); suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 2–4 g of myo-inositol per day. The most commonly recommended dose for myo-inositol in PCOS treatment is 4 g per day, often divided into two doses of 2 g each. A 12-week randomized controlled trial in 192 women with PCOS used myo-inositol 2 g plus D-chiro-inositol 50 mg twice daily (4 g myo-inositol total daily). Doses of 2–4 g/day are considered safe in standard randomized controlled trials. For mood and anxiety support, higher doses up to 18 g/day have been used in clinical studies. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.