• Premium Liposomal quercetin 70% Cellular Defense and Anti-Inflammatory Formula

Product Detailed Description

Liposomal Quercetin 70% — High Bioavailability Flavonoid Supplement

Product Overview

Liposomal Quercetin 70% is a premium-grade dietary supplement ingredient delivering quercetin in an advanced liposomal delivery system. Quercetin is a pentahydroxyflavone (3,3′,4′,5,7-pentahydroxyflavone) belonging to the flavonol subclass of flavonoids, with the molecular formula C₁₅H₁₀O₇ and a molecular weight of 302.24 g/mol. It is one of the most abundant flavonoids in edible vegetables, fruits, and wine, and is widely distributed in apples, onions, berries, green tea, and herbal medicines.

Quercetin has been extensively studied for its broad-spectrum pharmacological activities, including antioxidant, anti-inflammatory, anti-allergic, cardioprotective, neuroprotective, and senotherapeutic effects. It acts through multiple mechanisms, including activation of the Nrf2/ARE antioxidant response pathway and inhibition of NF-κB and the NLRP3 inflammasome. However, its clinical potential is severely limited by extremely poor water solubility and low oral bioavailability. Liposomal encapsulation addresses these challenges by protecting quercetin from degradation and enhancing its delivery to target cells.

Why Liposomal Technology?

Conventional quercetin presents significant formulation challenges due to its poor aqueous solubility (less than 10 μg/mL), limited solubility in organic solvents, and poor stability under conditions of light, high temperature, and high humidity. Following oral administration, its bioavailability is low due to low solubility and easy metabolism in the gastrointestinal tract, with most quercetin being metabolized by intestinal flora or excreted with feces before absorption.

Liposomal encapsulation provides three critical advantages:

1. Solubility and Stability Enhancement — By encapsulating quercetin within a phospholipid bilayer, its solubility and stability are significantly improved. The phospholipid bilayer structure protects quercetin from the influence of the external environment while making it more dispersible in water, showing properties similar to colloidal solutions.

2. Digestive Protection — The liposomal membrane shields quercetin from enzymatic degradation and premature metabolism in the gastrointestinal tract, preserving its intact molecular structure until reaching target cells.

3. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. By encapsulating quercetin in liposomes, its stability, solubility, and bioavailability can be improved, making it have better application prospects in the fields of medicine and health products.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% quercetin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Sunflower phospholipid bilayer encapsulation significantly improves quercetin's solubility, stability, and bioavailability compared to standard quercetin.

• Senotherapeutic Activity — Quercetin exhibits dual senolytic (selectively eliminating senescent cells) and senomorphic (modulating the harmful effects of these cells) capabilities, targeting the fundamental biological hallmarks of aging.

• Antioxidant and Anti-Inflammatory — Quercetin activates the Nrf2/ARE signaling pathway, inducing endogenous antioxidant enzymes, while inhibiting NF-κB and the NLRP3 inflammasome.

• Immunomodulatory Effects — Quercetin modulates the MAPK signaling pathway, shifts macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2, and regulates immune responses.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated quercetin at doses ranging from 500 mg per day to 2,000 mg per day. A randomized controlled trial in patients with Type 2 Diabetes Mellitus demonstrated that 500 mg of daily quercetin supplementation over 32 weeks improved glycated hemoglobin (HbA1c), reduced systolic blood pressure, and improved lung function, sleep quality, anxiety levels, and overall quality of life. A pilot Phase II clinical trial in COPD patients used quercetin at 2,000 mg/day for 6 months and found it to be safely tolerated. A Phase 1 study in children and young adults with Fanconi anemia established a recommended dose with a maximum adult daily dose of 4,000 mg/d. For general antioxidant and immune support, 500 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.