Product Detailed Description

liposomal Calcium Citrate 80% — High Bioavailability Bone Health Supplement

Product Overview

Liposomal Calcium Citrate 80% is a premium-grade dietary supplement ingredient delivering calcium citrate in an advanced liposomal delivery system. Calcium citrate (CAS 813-94-5 for anhydrous; CAS 5785-44-4 for tetrahydrate) is the calcium salt of citric acid, chemically designated as 2-hydroxy-1,2,3-propanetricarboxylic acid calcium salt (2:3). It occurs as a white, odorless, crystalline powder that is soluble in water and contains approximately 21% elemental calcium.

Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth as hydroxyapatite complexes that provide strength and structure. The remaining 1% of "non-bone calcium" plays crucial roles in muscle contraction, nerve impulse transmission, blood clotting, and hormone secretion. Calcium citrate is preferred over calcium carbonate in several clinical situations, including chronic hypoparathyroidism, osteoporosis, hypochlorhydria (low gastric acid production), and bariatric surgery, because it does not depend on stomach acid for absorption. However, conventional calcium citrate still faces absorption limitations, and the rapid postprandial spike in serum calcium levels associated with traditional calcium supplements can lead to inefficient utilization.

Why Liposomal Technology?

Conventional calcium citrate already offers superior bioavailability compared to calcium carbonate. A meta-analysis of 15 studies demonstrated that calcium citrate is absorbed approximately 22–27% better than calcium carbonate, regardless of whether it is taken on an empty stomach or with meals. However, calcium absorption relies on tightly regulated intestinal transport systems, and increasing the administered dose does not proportionally enhance absorption efficiency but may instead lead to reduced fractional absorption and increased excretion.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability — A randomized crossover human absorption study demonstrated that solid-state liposomal calcium achieved a 1.56-fold increase in systemic calcium exposure compared to non-liposomal calcium. The AUC was 2.94 mg·h/dL for the liposomal group versus 1.88 mg·h/dL for the non-liposomal group.

2. Improved Absorption Kinetics — Liposomal calcium significantly increased blood calcium levels at early time points (1–2 h; p < 0.05) and maintained elevated levels up to 8 hours post-administration, indicating both a faster onset and a more sustained duration of action.

3. Lymphatic Absorption Pathway — By migrating directly into the lymphatic system, liposomal calcium avoids liver first-pass metabolism, elevating serum calcium safely and efficiently. This delivery route bypasses the rapid postprandial spike in serum calcium levels that can occur with traditional calcium supplements.

4. Reduced Gastrointestinal Side Effects — Liposomal encapsulation minimizes direct contact between calcium and the gastrointestinal mucosa, reducing the risk of the constipation and bloating frequently associated with conventional calcium supplements.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% calcium citrate, with elemental calcium content of ≥20.0%.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves a 1.56-fold increase in systemic calcium exposure compared to non-liposomal calcium.

• Superior Bioavailability — Calcium citrate is absorbed approximately 22–27% better than calcium carbonate, and liposomal encapsulation further enhances this advantage through lymphatic absorption pathways.

• Stomach-Acid Independent — Calcium citrate is absorbed equally well with or without food, making it ideal for individuals with low stomach acid, those taking proton pump inhibitors, and older adults.

• Osteoporosis Prevention — Clinical studies have demonstrated that calcium citrate supplementation (400 mg of calcium twice daily) averted bone loss and stabilized bone density in the spine through parathyroid suppression and inhibition of bone resorption.

• Reduced Kidney Stone Risk — Calcium citrate, in contrast to other calcium salts, reduces the risk of kidney stone formation.

• Enhanced Stability — Liposomal formulations exhibit remarkable physicochemical stability over a 6-month storage period at 4°C and 25°C, with retention rates of >98% for calcium.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

According to the International Osteoporosis Foundation, the recommended daily calcium intake for both women and men aged 19 to 50 years is 1,000 mg. This increases to 1,200 mg from the age of 51 in women, and after 70 in men. Approximately 20–30% of ingested dietary calcium is absorbed by the gut. Calcium citrate supplements typically provide 200–400 mg of elemental calcium per serving, and because calcium citrate is only 21% calcium, more tablets may be needed to meet daily requirements compared to calcium carbonate. The Tolerable Upper Intake Level (UL) for calcium is 2,000–2,500 mg per day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.