Product Detailed Description

Liposomal Ferric Phosphate 80% — High Bioavailability Gentle Iron Supplement

Product Overview

liposomal Ferric Phosphate 80% is a premium-grade dietary supplement ingredient delivering ferric phosphate in an advanced liposomal delivery system. Ferric phosphate (CAS 10045-86-0), also known as iron(III) phosphate or ferric orthophosphate, is an inorganic iron salt composed of ferric iron (Fe³⁺) and phosphate anions (PO₄³⁻). It is chemically characterized by the molecular formula FePO₄·nH₂O (anhydrous molecular weight 150.82 g/mol) and occurs as a pale yellow to off-white, odorless powder that is insoluble in water but soluble in acids.

Iron is an essential trace mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Ferric phosphate is a widely used iron fortificant due to its excellent sensory neutrality and stability. It is virtually tasteless and odorless, and does not impart undesirable color or oxidative deterioration to food products, making it the preferred iron source for fortifying rice, cereals, and other sensitive food matrices where soluble iron salts would cause unacceptable taste or appearance changes. However, ferric phosphate is poorly soluble in water, with solubility in 0.1N HCl being the parameter that most highly correlates with its bioavailability.

Why Liposomal Technology?

Conventional ferric phosphate presents significant formulation challenges. The compound is water-insoluble, and its limited solubility results in a low relative bioavailability compared to soluble iron salts such as ferrous sulfate. Studies have demonstrated that the relative bioavailability of ferric orthophosphate is strongly influenced by particle size and solubility in 0.1N HCl, with commercial samples varying widely from 6 to 46 RBV.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Bioavailability — Liposomal iron (iron phosphate encapsulated within a phospholipid membrane) has enhanced iron bioavailability. Once ingested, liposomes remain stable in the stomach and are absorbed intact in the small intestine via M cells, primarily in the duodenum, through endocytosis or membrane fusion. A study on iron pyrophosphate nanoparticles demonstrated that encapsulation efficiency in liposomes was significantly enhanced from 27.8% for unmodified nanoparticles to 74.9% for modified nanoparticles, with intracellular iron concentrations reaching 171.54 μmol/L compared to 115.24 μmol/L for unencapsulated iron, and total antioxidant levels reaching 9.04 U/mg prot vs. 7.28 U/mg prot.

2. Clinically Validated Superior Hemoglobin Response — A randomized controlled trial in children aged 6–59 months compared oral liposomal ferric phosphate with ferrous sulfate as intermittent prophylaxis. Forty children in each group received 20 mg elemental iron twice weekly for 3 months. The liposomal iron group showed significant improvements in mean hemoglobin (p < 0.0001), serum iron (p = 0.0444), TSAT (p = 0.008), MCHC (p = 0.0491), and RDW (p = 0.0225) levels. At follow-up, the liposomal iron group had greater improvements in mean hemoglobin [LFP: 0.76 g/dL vs. FS: 0.16 g/dL] and serum iron [LFP: 22.93 μg/dL vs. FS: 9.72 μg/dL] levels. The liposomal iron group experienced fewer side effects and better compliance (77% vs. 68.9% of doses administered).

3. Reduced Gastrointestinal Side Effects — In a pediatric CKD trial, adverse event incidence was lower in the liposomal iron group (19.4%) compared to the conventional iron group (43.7%). Liposomal iron has a pattern of better bioavailability and tolerance, with fewer adverse effects and good gastrointestinal absorption.

4. Sensory Neutrality — Ferric phosphate has minimal metallic odor and a relatively light color, which prevents it from imparting undesirable taste or color to food vehicles. Liposomal encapsulation further improves taste and stability by minimizing metallic taste and protecting iron from oxidation and interactions with food components.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% ferric phosphate, with elemental iron content of 26.0%–32.0%.

• Liposomal Enhancement — Phospholipid bilayer encapsulation enhances iron bioavailability and absorption through endocytosis and membrane fusion, with encapsulation efficiency up to 89.01%.

• Clinically Validated Superior Hemoglobin Response — Randomized controlled trial demonstrated significantly greater hemoglobin improvement (0.76 g/dL vs. 0.16 g/dL) and serum iron increase (22.93 μg/dL vs. 9.72 μg/dL) compared to ferrous sulfate.

• Superior Gastrointestinal Tolerability — Adverse event incidence was lower in the liposomal iron group (19.4%) compared to the conventional iron group (43.7%). Liposomal iron shows good compliance (77% vs. 68.9% of doses administered).

• GRAS and FDA Affirmed — Ferric phosphate is Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1301 for use as a nutrient supplement in conventional foods and infant formula.

• Sensory Neutral — Ferric phosphate has minimal metallic odor and a relatively light color, making it ideal for food fortification applications where taste and appearance are critical.

• Ideal for Rice Fortification — Ferric pyrophosphate (a related iron phosphate compound) was found to be the only acceptable iron fortificant for extruded rice because all other compounds colored the rice brown or gray.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, functional beverages, and food fortification applications.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated ferric phosphate across a range of doses. A randomized controlled trial in children aged 6–59 months used 20 mg elemental iron twice weekly for 3 months as intermittent iron prophylaxis. For food fortification, the recommended levels are: cereals and cereal products: 150–290 mg/kg (as elemental iron); beverages: 60–120 mg/kg (as elemental iron); dairy products and infant foods: 360–600 mg/kg (as elemental iron). For adult supplementation, 30–60 mg elemental iron per day is commonly used. Iron status should be monitored through hemoglobin, ferritin, and transferrin saturation to guide dosing. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.