Product Detailed Description

Liposomal ferrous fumarate 80% — High Bioavailability Gentle Iron Supplement

Product Overview

liposomal Ferrous Fumarate 80% is a premium-grade dietary supplement ingredient delivering ferrous fumarate in an advanced liposomal delivery system. Ferrous fumarate (CAS 141-01-5) is an iron(II) salt of fumaric acid, chemically designated as iron(2+) fumarate (1:1) or iron(2+) (E)-2-butenedioate (1:1). It is a fine, reddish orange or reddish brown powder that is slightly soluble in water and very slightly soluble in ethanol, and is most commonly used as a nutrient or dietary supplement.

Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Ferrous fumarate contains approximately 32% elemental iron—the highest among common ferrous salts—making it an efficient iron source. It has been recommended as a dietary supplement for infants and teenagers because of its superior sensory qualities and research showing that it can raise iron status. However, conventional ferrous salts, including ferrous fumarate, often cause nausea, abdominal discomfort, constipation, or diarrhea, which may lead to poor compliance or early discontinuation.

Why Liposomal Technology?

Conventional ferrous fumarate presents significant formulation challenges. While effective in replenishing iron stores, ferrous salts predictably cause dose-dependent gastrointestinal side effects. These adverse effects limit adherence and reduce treatment effectiveness in real-world settings.

Liposomal encapsulation provides four critical advantages:

1. Gastric Protection and Delayed Deterioration — The liposomal phospholipid bilayer is similar to that found in human cell membranes. Iron is able to withstand the stomach environment because of liposomal protection, which delays early deterioration and inactivation. This protective coating also prevents the early oxidation that usually happens with regular ferrous sulphate or ferrous fumarate tablets.

2. Direct Cellular Absorption — This allows liposomal iron to be directly absorbed through the enterocyte's cell membrane via endocytosis, vesicular fusion, and diffusion. Liposomal carriage of iron is linked to targeted delivery of iron and enables lower doses to be administered due to direct absorption into the bloodstream without the need for protein carriers.

3. Reduced Gastrointestinal Side Effects — Liposomal iron is associated with reduced exposure to gastric contents, decreased interaction with food contents, and no exposure to various digestive juices. The protective liposomal coating reduces gastrointestinal side effects like nausea and constipation. Liposomal iron formulations are absorbed two to three times better than regular iron salts.

4. Clinically Validated Superior Hemoglobin Response — A randomized controlled study comparing liposomal iron versus iron fumarate in 100 pregnant women with mild anemia (Hb 9–11 g/dL) demonstrated that hemoglobin at 28–32 weeks was significantly higher in the liposomal iron group (11.18 ± 0.44) than in the ferrous iron group (10.70 ± 0.39). Clinical research suggests that liposomal iron dramatically raises hemoglobin and ferritin levels in both pregnant women and women with iron insufficiency.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% ferrous fumarate, with elemental iron content of 31.79%–33.20% (USP/FCC).

• Highest Elemental Iron Content — Ferrous fumarate contains approximately 32% elemental iron, the highest among common ferrous salts, making it an efficient and concentrated iron source.

• Liposomal Enhancement — Phospholipid bilayer encapsulation shields iron from the gastric environment, delays early deterioration and inactivation, and enables direct cellular absorption through endocytosis, vesicular fusion, and diffusion.

• Clinically Validated Superior Hemoglobin Response — Randomized controlled study demonstrated significantly higher Hb levels at 28–32 weeks in the liposomal iron group (11.18 ± 0.44 g/dL) compared to ferrous fumarate (10.70 ± 0.39 g/dL).

• Improved Gastrointestinal Tolerability — The protective liposomal coating reduces gastrointestinal side effects like nausea and constipation, and liposomal iron formulations are absorbed two to three times better than regular iron salts.

• Reduced Dosing Frequency — Liposomal carriage of iron enables lower doses to be administered due to direct absorption into the bloodstream without the need for protein carriers.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated ferrous fumarate across a range of doses. A multicenter, randomized, open-label trial is comparing ferrous fumarate 200 mg once daily versus 400 mg on alternate days for 8 weeks in adults with iron deficiency anemia. A randomized controlled study in pregnant women with mild anemia used oral tablets at 180 mg/day for both the liposomal iron group and the iron fumarate group. Another study in pregnant women used alternate-day ferrous fumarate (305 mg, equivalent to 100 mg elemental iron) versus daily dosing. For general iron deficiency anemia treatment, 200 mg once daily or 400 mg on alternate days for 8 weeks is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.