Product Detailed Description

Liposomal spermidine hydrochloride 70% — High Bioavailability Autophagy Induction Supplement

Product Overview

liposomal Spermidine Hydrochloride 70% is a premium-grade dietary supplement ingredient delivering spermidine trihydrochloride in an advanced liposomal delivery system. Spermidine (CAS 124-20-9 for free base; CAS 334-50-9 for trihydrochloride) is a naturally occurring polyamine with the chemical name N-(3-aminopropyl)butane-1,4-diamine. The trihydrochloride form has the molecular formula C₇H₂₂Cl₃N₃ and a molecular weight of 254.63 g/mol, and is typically supplied as a white to off-white crystalline solid with purity ≥98%.

Spermidine is synthesized from putrescine and is present in all living organisms, where it plays essential roles in cell growth, proliferation, DNA and RNA stabilization, enzymatic modulation, and regulation of gene transcription and translation. The highest dietary concentrations are found in wheat germ, soybean products, and fermented foods such as cheese and miso. Spermidine is a natural, non-toxic autophagy inducer and has been characterized as a geroprotective compound that counteracts immunosenescence and supports healthy aging.

Why Liposomal Technology?

Conventional spermidine presents significant formulation challenges. The compound is highly hygroscopic and sensitive to oxidation, which limits its stability in powder and aqueous formulations. Spermidine also undergoes rapid metabolism and excretion, limiting its systemic bioavailability following oral administration.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability — Our liposomal format preserves spermidine’s identity while addressing hygroscopicity and oxidative sensitivity. The plant-derived phospholipid bilayer coating coats the polyamine within a protective shield that prevents moisture absorption and locks in ambient stability.

2. Improved Bioavailability — Liposomal delivery encapsulates spermidine in a lipid bilayer that mimics the body’s cell membranes, improving absorption into the bloodstream and resulting in enhanced bioavailability and efficacy. Liposomal spermidine trihydrochloride delivers spermidine encapsulated in phospholipid liposomes for improved bioavailability and a slower, steadier release.

3. Enhanced Dispersion and Formulation Flexibility — Liposomal encapsulation significantly optimizes ingredient dispersion and bioavailability in advanced supplement formulations. The liposomal form is dispersible in water, forming a stable liposomal suspension suitable for capsules, powders, and liquid formulations.

4. Clean-Label Compatible — The phospholipid carrier is sourced from plant-derived lipids, keeping the entire delivery system aligned with vegan values and clean-label positioning. No synthetic modifiers, solvent residues, or controversial processing aids are used.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% spermidine trihydrochloride by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Plant-derived phospholipid bilayer encapsulation achieves ≥80% encapsulation efficiency (typically ~83%), with rehydrated particle size of 80–300 nm and PDI ≤0.35, protecting spermidine from moisture absorption and oxidative degradation.

• Powerful Autophagy Induction — Spermidine is a naturally occurring, non-toxic autophagy inducer that triggers the cellular recycling process, removing damaged organelles and protein aggregates to maintain cellular homeostasis and support anti-aging effects.

• Clinically Validated for Immune Function — A double-blind, randomized, placebo-controlled pilot study in 40 adults over 65 years demonstrated that daily oral spermidine supplementation (6 mg, 13 weeks) was well-tolerated and significantly enhanced spike-specific IgG secretion, memory B cell recall responses, and neutralising antibody activity, specifically in vaccine non-responders.

• Epigenetic Regulation — Spermidine exerts anti-inflammatory action by reducing the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), inhibiting NF-κB translocation, and regulating lipid metabolism through the AMPK signaling pathway.

• Cellular and Neuronal Homeostasis — Spermidine interacts with nucleic acids, lipids, proteins, and ATP to modulate cell growth, cell proliferation, DNA and RNA stabilization, and gene transcription regulation.

• Water-Dispersible — Dispersible in water, forming a stable liposomal suspension; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated spermidine across a range of doses. A double-blind, randomized, placebo-controlled pilot study in 40 adults over 65 years following their third SARS-CoV-2 vaccine dose used daily oral spermidine supplementation at 6 mg for 13 weeks, demonstrating excellent tolerability and significantly enhanced vaccine-induced immunity in non-responders. An open-label dose-escalation study is evaluating spermidine in capsule form through three consecutive 28-day courses with escalating doses of 40 mg, 120 mg, and 400 mg. A German clinical trial registered varying daily doses of 12 mg, 24 mg, 48 mg, and 96 mg orally per day across four groups. For general healthy aging and autophagy support, 6–15 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.