Product Detailed Description

liposomal proanthocyanidins 70% — High Bioavailability Antioxidant Supplement

Product Overview

Liposomal Proanthocyanidins 70% is a premium-grade dietary supplement ingredient delivering proanthocyanidins in an advanced liposomal delivery system. Proanthocyanidins (CAS 4852-22-6), also known as procyanidins, oligomeric proanthocyanidins (OPCs), or procyanidolic oligomers (PCOs), are a class of polyphenolic bioflavonoids characterized by the molecular formula C₃₀H₂₆O₁₃ and a molecular weight of 594.52 g/mol. They are composed of oligomers and polymers of flavan-3-ol units, primarily catechin and epicatechin, linked through carbon-carbon bonds. Proanthocyanidins occur as reddish-brown to reddish-brown fine powder with a slight characteristic odor and astringent taste.

Proanthocyanidins are widely distributed in the plant kingdom, with the most commercially significant sources being grape seed extract (Vitis vinifera) and maritime pine bark extract (Pinus pinaster). Grape seed proanthocyanidin extract (GSPE) constituents are based on either catechin or epicatechin, and include monomers, dimers, trimers, and other oligomers, with dimeric procyanidins designated as procyanidin B1, B2, B3, and B4 depending on the configuration of catechin and epicatechin subunits. Proanthocyanidins are widely used for the treatment of vascular disorders such as varicose veins, venous insufficiency, and microvascular problems in Europe.

Why Liposomal Technology?

Conventional oral proanthocyanidins present significant bioavailability challenges. Proanthocyanidins display lower stability and are susceptible to degradation during storage and gastrointestinal transit. Their high molecular weight and polymeric nature limit their biological activity due to poor bioavailability, and the poor biostability and bioavailability of proanthocyanidins significantly limit their therapeutic applications.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Bioaccessibility — Ultrasonic-assisted nanoencapsulation of proanthocyanidins in liposomes using lecithin-based nanoliposomes achieved an encapsulation efficiency of 73.84% and increased bioaccessibility during in vitro digestion by 2.28–3.07-fold, with in vivo analyses showing over 200% increase in bioaccessibility compared to the control. This nanoliposomal delivery system effectively overcomes the bioavailability and stability limitations of free proanthocyanidins, providing new insights into the management of oxidative stress in inflammatory diseases.

2. High Encapsulation Efficiency and Stability — Liposomal and chitosan-coated liposomal nanocarriers for grape seed proanthocyanidins displayed high encapsulation efficiency exceeding 90% with particle sizes of 120–150 nm and low polydispersity. Co-encapsulation of proanthocyanidins with α-tocopherol in complex phospholipid liposomes achieved encapsulation efficiencies of 78.02% ± 2.02% and 81.67% ± 1.25%, respectively, with retention remaining above 60% after 30 days of storage at 4°C.

3. Synergistic Antioxidant Enhancement — Co-encapsulation of proanthocyanidins with α-tocopherol in complex phospholipid liposomes resulted in a synergistic antioxidant effect, with DPPH radical scavenging activity reaching 87.52%, significantly higher than that of single-embedded proanthocyanidin and α-tocopherol liposomes.

4. Sustained Release and Targeted Delivery — The release of proanthocyanidins from liposomal formulations during simulated digestion was low and followed the Ritger-Peppas release model, indicating a remarkable sustained release and delivery to the small intestine. Liposomal encapsulation protects proanthocyanidins from degradation during gastric transit and facilitates targeted delivery to the intestinal epithelium where absorption occurs.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% oligomeric proanthocyanidins by HPLC and ≥95% total proanthocyanidins by UV, ensuring consistent active content.

• Liposomal Enhancement — Ultrasonic-assisted nanoencapsulation achieves 73.84% encapsulation efficiency and increases bioaccessibility by 2.28–3.07-fold (in vitro) and over 200% (in vivo) compared to free proanthocyanidins.

• Potent Antioxidant Activity — Proanthocyanidins are among the most effective free radical scavengers ever discovered, with antioxidant activity significantly higher than vitamins C and E, and GSPE causes a 60–90% reduction in oxidation of LDL-C.

• Cardiovascular Health Support — Proanthocyanidins help maintain capillary integrity, support healthy venous function, and reduce LDL oxidation, supporting cardiovascular health.

• Clinically Studied for NAFLD — A randomized controlled trial in 50 patients with non-alcoholic fatty liver disease used 500 mg/day of GSE containing 250 mg of proanthocyanidins for two months.

• Clinically Studied for Cognitive Function — A randomized, double-blind, placebo-controlled clinical trial evaluated GSPE at 320 mg/day on cognitive function in older adults with mild cognitive impairment (MCI).

• Synergistic Formulation Potential — Co-encapsulation with α-tocopherol in complex phospholipid liposomes significantly enhances antioxidant activity through synergistic effects, with DPPH radical scavenging activity reaching 87.52%.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies have evaluated proanthocyanidins across a range of doses. A randomized controlled trial in 50 patients with non-alcoholic fatty liver disease used 2 tablets of grape seed extract containing 250 mg of proanthocyanidins per tablet for two months. A randomized, double-blind, placebo-controlled clinical trial evaluated grape seed proanthocyanidin extract (GSPE) at 320 mg per day on cognitive function in older adults with mild cognitive impairment (MCI). A study in patients with type 2 diabetes and urinary tract infections used GSPE at 300 mg once daily in combination with metformin for 12 weeks. Cranberry proanthocyanidins have been studied at doses of 2 × 18.5 mg daily (37 mg/day) for urinary tract infection prevention in healthy women. For general antioxidant and cardiovascular support, 100–250 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and protection from degradation.

Important Safety Information: Proanthocyanidins are generally well tolerated. The most common side effects are mild gastrointestinal discomfort, including nausea, abdominal cramping, and diarrhea, particularly at high doses. Individuals with known hypersensitivity to proanthocyanidins or related polyphenols should avoid supplementation. Proanthocyanidins may interact with certain medications, including anticoagulants and antiplatelet agents. Pregnant or lactating women and children should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.