Product Detailed Description

Liposomal vitamin B1 Thiamine Nitrate 70% — High Bioavailability Vitamin B1 Supplement

Product Overview

liposomal Vitamin B1 Thiamine Nitrate 70% is a premium-grade dietary supplement ingredient delivering thiamine nitrate in an advanced liposomal delivery system. Thiamine nitrate (CAS 532-43-4), also known as thiamine mononitrate, vitamin B1 nitrate, or 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate, is a synthetic, stable salt of thiamine (vitamin B1). It is chemically characterized by the molecular formula C₁₂H₁₇N₅O₄S and a molecular weight of 327.36 g/mol. The compound occurs as white to off-white crystalline powder or crystals with a melting point of approximately 193°C (with decomposition), is sparingly soluble in water, freely soluble in boiling water, and very slightly soluble in ethanol.

Thiamine nitrate is the most stable salt form of thiamine and is widely used in dietary supplements, food fortification, and pharmaceutical applications due to its superior stability compared to thiamine hydrochloride. Thiamine (vitamin B1) helps turn the food you eat into the energy you need and is important for the growth, development, and function of the cells in your body. As a cofactor for pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and transketolase, thiamine is indispensable for carbohydrate metabolism and nerve function.

Why Liposomal Technology?

Conventional thiamine nitrate presents significant bioavailability challenges. Water-soluble thiamine salts rely on saturable, rate-limited active transport mechanisms for intestinal absorption. As the dose increases, these transporters become saturated, and absorption efficiency declines. Additionally, thiamine is highly unstable in neutral to alkaline conditions (pH > 6), and the degradation rate increases significantly as the pH rises.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Bioavailability — Liposomal Vitamin B1 increases the bioavailability of vitamin B1 by 3–4 times, avoiding degradation by gastric acid and digestive loss. The phospholipid bilayer shields thiamine nitrate from the harsh gastric environment and facilitates efficient cellular uptake through lipid-mediated pathways.

2. pH-Dependent Controlled Release — The liposomal formulation exhibits a pH-dependent controlled-release profile, releasing the encapsulated vitamin B1 selectively in the intestinal environment where absorption is optimal. Research published in the International Journal of Molecular Sciences confirmed that the release of encapsulated vitamin B1 from liposomal nanocarriers is pH-dependent, enabling targeted delivery to the small intestine.

3. Enhanced Stability and Protection — The phospholipid bilayer effectively protects vitamin B1, resisting oxidation, light exposure, and high temperatures, preventing its failure during storage and processing. Nanoliposomes containing thiamine have been demonstrated to be highly stable for up to 3 months at different temperatures.

4. Gentle on the Stomach and Water-Dispersible — Liposomal Thiamine has no irritation to the gastrointestinal tract and does not require a complex digestive process. The liposomal powder can quickly disperse in water to form a uniform suspension, suitable for functional beverages and liquid formulations.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% thiamine nitrate by HPLC, with USP/EP/JP grade assay of 98.0%–102.0% on dried basis available.

• Liposomal Enhancement — Liposomal Vitamin B1 increases bioavailability by 3–4 times compared to conventional thiamine, avoiding degradation by gastric acid and digestive loss.

• pH-Dependent Controlled Release — The liposomal formulation releases the encapsulated vitamin B1 selectively in the intestinal environment, where absorption is optimal.

• Superior Stability — Thiamine nitrate is the most stable salt form of thiamine, and liposomal encapsulation further protects it from oxidation, light, and high-temperature degradation.

• Energy Metabolism Support — Thiamine is an essential cofactor for pyruvate dehydrogenase and other enzymes in carbohydrate metabolism, helping to convert food into the energy the body requires.

• Nervous System Health — Liposomal Vitamin B1 heals injured nerve cells, controls nerve conduction, and reduces symptoms including neuritis and nerve numbness.

• Cognitive Function Support — Thiamine participates in the synthesis of brain neurotransmitters and enhances the brain‘s blood and oxygen supply to boost mental and cognitive function.

• Immune Function — Liposomal Thiamine regulates the balance of body metabolism and enhances the activity of immune cells.

• Water-Dispersible — Liposomal powder can quickly disperse in water to form a uniform suspension; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for thiamine is 1.2 mg/day for adult men and 1.1 mg/day for adult women. During pregnancy and lactation, the requirement increases to 1.4 mg/day. For supplemental use, many multivitamin supplements provide 20–25 mg of thiamine, which is more than adequate for most people. There is no clear evidence to suggest that either thiamine hydrochloride or thiamine nitrate—the two most commonly used supplement forms of thiamine—is preferable to the other. For therapeutic applications in thiamine deficiency, doses of up to 100 mg/day may be used under medical supervision. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: Thiamine nitrate is generally well tolerated. Thiamine is a water-soluble vitamin, and excess amounts are excreted in the urine. No tolerable upper intake level (UL) has been established for thiamine due to its low toxicity. Individuals with known hypersensitivity to thiamine or its derivatives should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. Thiamine nitrate should not be used concurrently with strong oxidizing agents.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.