Product Detailed Description

Liposomal apigenin 70% — High Bioavailability Flavonoid Supplement

Product Overview

liposomal Apigenin 70% is a premium-grade dietary supplement ingredient delivering apigenin in an advanced liposomal delivery system. Apigenin (CAS 520-36-5), also known as 4′,5,7-trihydroxyflavone or 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, is a naturally occurring flavone belonging to the flavonoid class of plant secondary metabolites. It is chemically characterized by the molecular formula C₁₅H₁₀O₅ and a molecular weight of 270.24 g/mol. Apigenin is a yellow crystalline powder that is practically insoluble in water, with a solubility of less than 1 μg/mL to 2.16 μg/mL.

Apigenin is widely distributed in the plant kingdom and is the primary bioactive flavonoid in chamomile (Chamomilla matricaria L.), containing 3,000–5,000 μg/g in dried flower heads. Other rich dietary sources include parsley (45,035 μg/g), celery seeds (786.5 μg/g), and vine spinach (622 μg/g). Apigenin exhibits a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, neuroprotective, and senomorphic effects. Emerging clinical studies are beginning to affirm apigenin's therapeutic benefits, showing positive effects in treating cancer, cardiovascular diseases, diabetes, neurodegenerative disorders, and inflammatory conditions.

Why Liposomal Technology?

Conventional apigenin presents significant formulation challenges. The compound has poor aqueous solubility (less than 1 μg/mL), chemical instability, and low bioavailability, severely limiting its potential utilization in functional foods and supplements. Apigenin may also be inactivated in the gastrointestinal acidic environment, resulting in low bioavailability in vivo.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Solubility and Bioavailability — Liposomal encapsulation significantly improves the aqueous solubility of apigenin. Chitosan-coated apigenin liposomes (SCAL) demonstrated improved aqueous solubility (10.22 ± 0.18 mg/L), higher antioxidant capacity, and stability against simulated gastrointestinal digestion compared with unencapsulated apigenin. A dual-drug loaded liposomal nanocarrier bearing apigenin and 5-fluorouracil demonstrated a 262% increase in bioavailability compared to free apigenin.

2. Gastric Protection and Enhanced Stability — The phospholipid bilayer shields apigenin from premature degradation in the gastrointestinal tract and from oxidative degradation. The significant stability of the obtained amorphous apigenin dispersion was demonstrated for 12 months.

3. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism bypasses passive diffusion limitations and supports enhanced systemic absorption. Apigenin-loaded stealth liposomes demonstrated higher plasma retention time and stability, with improved bioavailability and enhanced therapeutic efficacy compared to standard apigenin.

4. Sustained Release — Liposomal formulations provide controlled release of apigenin, with the optimized apigenin-loaded liposome showing higher percentage drug release than plain apigenin following the Higuchi release model.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% apigenin by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves up to 262% increase in bioavailability compared to free apigenin, with improved aqueous solubility and stability against gastrointestinal digestion.

• Senomorphic Activity — Apigenin exhibits senomorphic potential, modulating the senescence-associated secretory phenotype (SASP) and supporting healthy cellular aging.

• Neuroprotective Effects — Apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes. It has demonstrated neuroprotective effects in preclinical models of Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

• Sleep Quality Support — Apigenin is a bioactive compound in chamomile tea, and clinical research has shown partial anxiolytic benefit with chamomile extract standardized to apigenin.

• Anti-Inflammatory and Antioxidant — Apigenin inhibits pro-inflammatory mediators and acts as a competitive CYP2C9 inhibitor (Ki = 2 μM), with broad antioxidant activity across numerous biological processes.

• Water-Dispersible — Liposomal encapsulation significantly improves aqueous dispersibility; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Dietary intake of apigenin is estimated at 0.45–5 mg daily from food sources. Commercial supplements typically contain 50 mg per capsule, and a common suggested use is one capsule daily. For best absorption, take at dinner or before bed with a source of dietary fat. Clinical trials using chamomile extract standardized to apigenin have used 200–1,000 mg per day for 8 weeks, providing approximately 2.4–12 mg of apigenin daily. Animal studies suggest that equivalent human doses may be in the range of 200–600 mg per day before accounting for metabolism. For general cellular health and sleep support, 50–100 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.