• Premium liposomal Bisbentiamine 70% Neuropathy and Cellular Energy Support Formula

Product Summary

Liposomal Bisbentiamine 70% is a high-purity, liposomal-encapsulated form of bisbentiamine (O-benzoylthiamine disulfide)—a lipid-soluble synthetic thiamine (vitamin B1) derivative engineered for superior membrane permeability and oral bioavailability—standardized to ≥70% active content. Bisbentiamine is a disulfide-linked, O-benzoylated thiamine derivative with a molecular weight of 770.9 g/mol and a LogP of 5.59, which enables passive membrane diffusion across the intestinal epithelium and the blood-brain barrier, in contrast to water-soluble thiamine salts (LogP ≈ −3.0) that rely on saturable carrier-mediated transport. Lipid-soluble thiamine precursors such as bisbentiamine have a much higher bioavailability than genuine thiamine and are therefore more suitable for therapeutic purposes. Bisbentiamine is efficiently converted to active thiamine diphosphate (TDP) in erythrocytes and tissues, supporting transketolase activity in the pentose phosphate pathway and Energy Metabolism in nerve tissue. Bisbentiamine is pH-dependently soluble, dissolving readily in acidic environments and poorly at neutral pH, and is intrinsically resistant to thiaminase degradation. However, native bisbentiamine presents formulation challenges including pH-dependent solubility and limited aqueous dispersibility. Liposomal encapsulation within a phospholipid bilayer addresses these limitations by protecting bisbentiamine from premature degradation during digestive transit and facilitating efficient cellular delivery. This water-dispersible powder is suitable for capsules, functional beverages, and nutritional formulations targeting vitamin B1 supplementation, nerve health, and cellular energy metabolism. Each batch is HPLC-standardized and quality-tested for purity, identity, and bisbentiamine content.