79$/KG
Product Detailed Description
liposomal Salicylic Acid 80% is a premium-grade dietary supplement ingredient delivering salicylic acid in an advanced liposomal delivery system. Salicylic acid (CAS 69-72-7), also known as 2-hydroxybenzoic acid or o-hydroxybenzoic acid, is a beta hydroxy acid (BHA) with the molecular formula C₇H₆O₃ and a molecular weight of 138.12 g/mol. It is a white crystalline powder that is poorly soluble in water (0.2% at 20°C) and is characterized by a pKa of 2.9 and a density of 1.44 g/cm³. Salicylic acid is the active metabolite of acetylsalicylic acid (aspirin) and is found naturally in the bark of willow trees and in various fruits and vegetables.
Salicylic acid is a lipophilic compound that penetrates the sebaceous follicles of the skin, where it exerts keratolytic, comedolytic, and anti-inflammatory effects. It works by dissolving the intercellular cement that holds corneocytes together, thereby promoting desquamation and unclogging pores. Salicylic acid has been present in OTC topical acne preparations at concentrations of 2% to 5%, external analgesics, skin protectants, and topical antifungal drugs. It is an approved active ingredient for use in topical OTC acne drug products at concentrations of 0.5% to 2%.
Conventional salicylic acid presents significant formulation challenges. The compound is poorly water-soluble and can cause irritation and stinging at effective concentrations. Following topical application, salicylic acid is rapidly absorbed through the skin, with approximately 15% of the systemic exposure of an oral 81 mg aspirin dose following application of a 2% topical product. This rapid systemic absorption limits its residence time in the target skin layers.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Skin Retention and Reduced Systemic Absorption — Liposomal encapsulation of salicylic acid resulted in a decrease in systemic absorption relative to control formulations and an increase in skin concentration, especially in the stratum corneum and epidermis. This targeted delivery profile maximizes local efficacy while minimizing systemic exposure.
2. Prolonged Tissue Residence Time — A salicylic acid/γ-cyclodextrin (SA/γ-CyD) conjugate entrapped in liposomes demonstrated a higher entrapment ratio than SA alone, with the release of the conjugate from RAW264.7 cells markedly slower compared with free SA. The residence time of the conjugate in tissues was significantly prolonged compared with conventional liposomal systems.
3. Protection from Degradation — The SA/γ-CyD conjugate in solid state was found to be an amorphous powder, and the release of SA from the conjugate in phosphate-buffered saline was tolerant to chemical and enzymatic degradation, demonstrating enhanced stability of the encapsulated form.
4. Sustained Release for Prolonged Activity — Liposomal delivery provides a controlled-release profile that maintains steady levels of salicylic acid at the target site, supporting prolonged keratolytic and sebum-regulating activity rather than a sharp peak followed by rapid clearance.
High Purity — Standardized to ≥80% salicylic acid by HPLC, with typical purity of 99.7–99.9% for premium cosmetic-grade material.
Liposomal Enhancement — Phospholipid bilayer encapsulation achieves decreased systemic absorption and increased skin concentration, especially in the stratum corneum and epidermis.
Prolonged Tissue Residence — SA/γ-CyD conjugate entrapped in liposomes demonstrated a higher entrapment ratio and significantly prolonged residence time in tissues compared with conventional liposomal systems.
Sebum-Regulating and Anti-Acne — Salicylic acid penetrates lipid-rich sebaceous follicles, dissolves intercellular cement, and reduces corneocyte cohesion to unclog pores and reduce acne.
Keratolytic and Skin-Renewing — Promotes desquamation and skin renewal by dissolving the intercellular cement that holds corneocytes together.
Anti-Inflammatory Support — Salicylic acid exhibits anti-inflammatory activity that reduces acne inflammation and redness.
Regulatory Compliant — Salicylic acid is an FDA-approved active ingredient for topical OTC acne drug products at concentrations of 0.5% to 2%. CIR Expert Panel concluded that salicylic acid is "safe as used when formulated to avoid irritation and when formulated to avoid increased sun sensitivity".
Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 50–100 mg per serving | 1–2 capsules daily with meals |
| Functional Beverages | 25–50 mg per 250 mL | Water-dispersible; suitable for RTD formats |
| Powdered Drink Mixes | 50–200 mg per sachet | Best absorbed when taken with food |
| Sebum Regulation Formulas | 50–100 mg per serving | Often combined with zinc, niacinamide, or green tea extract |
| Skin Renewal Formulas | 50–100 mg per serving | Often combined with vitamin C, collagen, or hyaluronic acid |
| Anti-Acne Formulas | 50–100 mg per serving | Often combined with zinc, vitamin B6, or probiotics |
| Topical Formulations | 0.5–2% in formulation | Compatible with non-ionic emulsifiers; can be compounded with niacinamide, hyaluronic acid, or glycerin |
Clinical studies and regulatory guidelines provide guidance on salicylic acid dosing. For topical OTC acne drug products, salicylic acid is approved at concentrations of 0.5% to 2%. Salicylic acid has been present in OTC topical acne preparations at concentrations of 2% to 5%, external analgesics and skin protectants for poison ivy, oak, and sumac, and topical antifungal drugs. For treating corns, salicylic acid ointment at approximately 5% concentration is applied twice daily, and for antifungal corn treatments, compound salicylic acid liniment at approximately 6% concentration is applied 3–4 times daily. For oral supplementation, 50–200 mg per day is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and targeted skin delivery.
Important Safety Information: Salicylic acid should not be used by individuals with known hypersensitivity to salicylates or aspirin. The FDA advises that similar precautions be taken for the use of cosmetics containing BHAs: test any product on a small area of skin before applying it to a large area; if skin irritation or prolonged stinging occurs, stop using the product and consult a physician; do not exceed the recommended applications; avoid using BHA-containing products on infants and children; and use sun protection if using a BHA product. Pregnant or lactating women and children should consult a healthcare professional before use. The long-term safety of salicylic acid in cosmetics is being evaluated in studies initiated by FDA and sponsored by the National Toxicology Program.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
79$/KG
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