Liposomal magnesium lactate 80% — High Bioavailability Magnesium Supplement

Product Overview

liposomal Magnesium Lactate 80% is a premium-grade dietary supplement ingredient delivering magnesium lactate in an advanced liposomal delivery system. Magnesium lactate (CAS 18917-93-6 for anhydrous; CAS 179308-96-4 for octahydrate) is the magnesium salt of lactic acid, chemically characterized by the molecular formula C₆H₁₀MgO₆ (anhydrous) and a molecular weight of 202.45 g/mol. The octahydrate form has a molecular weight of 238.48 g/mol. It is a white crystalline or granular powder that is practically odorless, has a neutral taste, and is soluble in water with good solubility (84 g/L).

Magnesium is the fourth most abundant cation in the human body and serves as an essential cofactor for more than 300 enzymatic reactions, including all enzymatic processes involving ATP. It plays a critical role in neurochemical transmission and muscular excitability, and is essential for maintaining normal bone density, cardiac rhythmicity, pulmonary function, and blood glucose regulation. Magnesium lactate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability, neutral taste, and excellent gastrointestinal tolerability. The lactate component provides an additional benefit—it is a natural energy source that muscles and the heart utilize directly.

Why Liposomal Technology?

Magnesium lactate already offers superior bioavailability compared to inorganic magnesium salts. A landmark comparative bioavailability study in normal volunteers demonstrated that magnesium oxide had a fractional absorption of only 4%, while magnesium lactate showed significantly higher absorption equivalent to magnesium chloride and magnesium aspartate. However, even well-absorbed magnesium salts face challenges related to the saturable nature of intestinal magnesium transport and the potential for gastrointestinal discomfort at higher doses.

Liposomal encapsulation provides four critical advantages:

1. Superior Bioavailability and Sustained Plasma Levels — A randomized, controlled, two-group human clinical trial in 20 metabolically healthy volunteers compared the bioavailability of 400 mg magnesium in liquid liposomal form versus non-liposomal tablet form. The liquid liposomal magnesium supplement achieved up to 5.18 times higher bioavailability than the non-liposomal tablet form. Liposomal magnesium also maintained elevated plasma levels throughout the entire study period, demonstrating sustained high concentrations during daily supplementation.

2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. The liposomal delivery system bypasses the saturable nature of carrier-mediated magnesium transport, providing an alternative route of cellular entry.

3. Gastrointestinal Protection — The phospholipid bilayer shields the magnesium-lactate complex from premature interaction with gastric contents, minimizing direct contact between magnesium and the gastrointestinal mucosa. Magnesium lactate is already known for its lack of laxative side effects compared to magnesium oxide and citrate, and liposomal encapsulation further enhances tolerability.

4. Neutral Taste and Excellent Dispersibility — Magnesium lactate has a neutral taste and is practically odorless. Liposomal encapsulation provides excellent water dispersibility, making it suitable for a wide range of beverage and liquid formulations.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% magnesium lactate, with elemental magnesium content of ≥12.0%.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves up to 5.18 times higher bioavailability compared to non-liposomal magnesium in tablet form in human clinical study, with sustained elevated plasma levels.

• Superior Bioavailability — Magnesium lactate demonstrates significantly higher absorption than magnesium oxide, with bioavailability equivalent to magnesium chloride and magnesium aspartate in comparative clinical studies.

• GRAS and FDA Affirmed — Magnesium lactate is self-affirmed Generally Recognized As Safe (GRAS) up to 20% of the daily value of magnesium when used in fortified food and beverages and is in full compliance with the US FDA. FDA GRAS Notice GRN 570 covers its use as a source of dietary magnesium in fruit-flavored beverages.

• No Laxative Side Effects — Magnesium lactate is absorbed more easily by the intestines compared to oxide or other inorganic forms, without the laxative side effects commonly associated with magnesium oxide and citrate.

• Synergistic Lactate Benefit — The lactate component binds to lactic acid, a natural energy source utilized by muscles and the heart.

• Clinically Studied for Muscle Cramps — Clinical trials have used 336 mg/day of slow-release magnesium lactate and 366 mg/day from primarily magnesium lactate and magnesium citrate tablets for skeletal muscle cramp relief.

• Water-Dispersible — Good solubility in water (84 g/L); neutral taste and practically odorless; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 200–400 mg of elemental magnesium per day from magnesium lactate. A representative commercial slow-release magnesium lactate tablet contains 84 mg elemental magnesium, with a suggested dose of two tablets twice daily (336 mg/day). For liposomal magnesium formulations, commercial products typically recommend 15 mL (providing 200 mg elemental magnesium) once daily for adults as a maintenance dose. A clinical trial in patients with implantable cardioverter defibrillators used oral magnesium L-lactate at 3 tablets twice daily (504 mg elemental magnesium daily) for 12 months. The Recommended Dietary Allowance (RDA) for elemental magnesium is 310–320 mg/day for adult females and 400–420 mg/day for adult males. The Tolerable Upper Intake Level (UL) for supplemental magnesium is 350 mg/day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.