Product Detailed Description

Liposomal vitamin B1 Hydrochloride Thiamine 70% — High Bioavailability Vitamin B1 Supplement

Product Overview

liposomal Vitamin B1 Hydrochloride Thiamine 70% is a premium-grade dietary supplement ingredient delivering thiamine hydrochloride in an advanced liposomal delivery system. Thiamine hydrochloride (CAS 67-03-8), also known as thiamine monohydrochloride, vitamin B1 hydrochloride, or aneurine hydrochloride, is the chloride-hydrochloride salt of thiamine, chemically characterized by the molecular formula C₁₂H₁₇ClN₄OS·HCl and a molecular weight of 337.27 g/mol. It occurs as colorless crystals or a white or yellowish-white crystalline powder with a slight characteristic odour reminiscent of thiazole or yeast, and is freely soluble in water (1 g in about 1 mL), soluble in glycerin, slightly soluble in alcohol, and practically insoluble in ether and benzene.

Thiamine hydrochloride is the most widely used and pharmacopoeially referenced salt form of vitamin B1, monographed in the USP, European Pharmacopoeia, International Pharmacopoeia, and Japanese Pharmacopoeia. It is affirmed as Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1875 for use as a flavoring agent and adjuvant or as a nutrient supplement, with no limitation other than current good manufacturing practice. Thiamine (vitamin B1) helps turn the food you eat into the energy you need and is important for the growth, development, and function of the cells in your body.

Why Liposomal Technology?

Conventional thiamine hydrochloride presents significant bioavailability challenges. Water-soluble thiamine salts rely on saturable, rate-limited active transport mechanisms for intestinal absorption. As the dose increases, these transporters become saturated, and absorption efficiency declines. Additionally, thiamine is highly unstable in neutral to alkaline conditions (pH > 6), and the degradation rate increases significantly as the pH rises. Even in the absence of light, thiamine hydrochloride is gradually degraded on exposure to a humid atmosphere, with decomposition being faster at higher temperatures.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Retention and Bioavailability — Thiamine hydrochloride-loaded asolectin-based liposomes with average hydrodynamic diameters of approximately 225 nm (physiological pH) and 245 nm (acidic pH) demonstrated 4.5-fold larger drug retention compared to unpackaged vitamin B1 under physiological conditions and 1.5-fold larger retention in artificial gastric juice. This enhanced retention translates directly into improved bioavailability and prolonged biological activity.

2. pH-Dependent Controlled Release — The liposomal formulation exhibits a pH-dependent controlled-release profile, releasing the encapsulated vitamin B1 selectively in the intestinal environment where absorption is optimal. Research published in the International Journal of Molecular Sciences confirmed that the release of encapsulated vitamin B1 from liposomal nanocarriers is pH-dependent, enabling targeted delivery to the small intestine.

3. Enhanced Stability and Protection — The phospholipid bilayer shields thiamine hydrochloride from the harsh gastric environment and protects it from oxidation, light, and high-temperature degradation. Nanoliposomes containing thiamine have been demonstrated to be highly stable for up to 3 months at different temperatures.

4. Gentle on the Stomach and Water-Dispersible — Liposomal Thiamine has no irritation to the gastrointestinal tract and does not require a complex digestive process. The liposomal powder can quickly disperse in water to form a uniform suspension, suitable for functional beverages and liquid formulations.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% thiamine hydrochloride in the liposomal formulation, with USP/EP/JP-grade assay of 98.0%–102.0% on anhydrous basis available.

• Liposomal Enhancement — Liposomal encapsulation achieves 4.5-fold larger drug retention under physiological conditions and 1.5-fold larger retention in artificial gastric juice compared to unpackaged vitamin B1.

• pH-Dependent Controlled Release — The liposomal formulation releases encapsulated vitamin B1 selectively in the intestinal environment where absorption is optimal.

• Superior Stability — Thiamine hydrochloride liposomes are highly stable for up to 3 months at different temperatures, and the phospholipid bilayer protects against oxidation, light, and heat degradation.

• Energy Metabolism Support — Thiamine is an essential cofactor for pyruvate dehydrogenase and other enzymes in carbohydrate metabolism, helping to convert food into ATP, the primary energy currency of cells.

• Nervous System Health — Liposomal Vitamin B1 heals injured nerve cells, controls nerve conduction, and reduces symptoms including neuritis and nerve numbness.

• Clinically Established for Thiamine Deficiency — Thiamine hydrochloride is indicated for the prevention and treatment of vitamin B1 deficiencies including beriberi, deficiency related to chronic alcoholism, and Wernicke-Korsakoff syndrome.

• GRAS and FDA Affirmed — Thiamine hydrochloride is Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1875 for use as a flavoring agent and adjuvant or as a nutrient supplement, with no limitation other than current good manufacturing practice.

• Water-Dispersible — Liposomal powder can quickly disperse in water to form a uniform suspension; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for thiamine is 1.2 mg/day for adult men and 1.1 mg/day for adult women. During pregnancy and lactation, the requirement increases to 1.4 mg/day. For supplemental use, many multivitamin supplements provide 20–25 mg of thiamine, which is more than adequate for most people. For therapeutic applications in thiamine deficiency, oral doses of 5–30 mg either as a single or in divided doses are typical, with severe deficiency including beriberi potentially requiring up to 300 mg daily in three divided doses under medical supervision. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: Thiamine hydrochloride is generally well tolerated. Thiamine is a water-soluble vitamin, and excess amounts are excreted in the urine. No tolerable upper intake level (UL) has been established for thiamine due to its low toxicity. Individuals with known hypersensitivity to thiamine or its derivatives should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. Thiamine hydrochloride should not be used concurrently with strong oxidizing agents and is incompatible with mercuric chloride, iodine, and iron salts.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas