Product Detailed Description

Liposomal calcium citrate malate 80% — High Bioavailability Bone Health Supplement

Product Overview

liposomal Calcium Citrate Malate 80% is a premium-grade dietary supplement ingredient delivering calcium citrate malate (CCM) in an advanced liposomal delivery system. Calcium citrate malate (CAS 142606-53-9) is a water-soluble calcium complex formed from calcium, citric acid, and malic acid in a 6:2:3 molar ratio, chemically characterized as Ca₆(C₆H₅O₇)₂(C₄H₄O₅)₃·6H₂O with a molecular weight of 1123.1 g/mol. It is a white, water-soluble powder with a pleasant fruity taste, making it suitable for both solid and liquid dosage forms.

Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth as hydroxyapatite. The remaining 1% of "non-bone calcium" plays critical roles in muscle contraction, nerve impulse transmission, blood clotting, and hormone secretion. Calcium citrate malate is recognized by the European Food Safety Authority as "slightly more bioavailable" than other calcium sources and has been the subject of extensive clinical research in bone health.

Why Liposomal Technology?

Calcium citrate malate already offers superior bioavailability compared to calcium carbonate, with clinical studies demonstrating significantly better absorption in both rats and humans. However, even water-soluble calcium salts face absorption challenges related to saturable intestinal transport systems and interactions with dietary inhibitors.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability and Protection — The phospholipid bilayer shields the calcium-citrate-malate complex from premature interaction with gastric contents and dietary inhibitors, preserving its intact structure until reaching optimal absorption sites in the small intestine.

2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. The citrate-malate component of CCM facilitates paracellular absorption, and liposomal encapsulation complements this mechanism for enhanced systemic uptake.

3. Superior Bioavailability — CCM has been shown to form significantly higher levels of soluble complexes at intestinal pH (pH 7.0) compared to other calcium salts, including calcium phosphate, which precipitates extensively under the same conditions. This solubility advantage translates directly into superior absorption.

4. Gentle on Digestion — Liposomal encapsulation minimizes direct contact between calcium and the gastrointestinal mucosa, reducing the risk of constipation and bloating frequently associated with conventional calcium supplements.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% calcium citrate malate, with elemental calcium content of 23.0%–24.2% (USP).

• Superior Bioavailability — Clinical studies demonstrate that calcium from CCM is absorbed significantly better than from calcium carbonate or milk in both animal and human studies.

• Water-Soluble Complex — CCM forms a soluble complex at intestinal pH (pH 7.0), unlike calcium phosphate which precipitates extensively under the same conditions.

• Stomach-Acid Independent — CCM is absorbed equally well with or without food, making it ideal for individuals with low stomach acid, those taking proton pump inhibitors, and older adults.

• Clinically Validated for Bone Health — A three-year, double-blind, placebo-controlled trial in 70 pairs of identical twins (mean age 10 ± 2 years) demonstrated that 1,000 mg/day of calcium citrate malate significantly increased bone mineral density.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects the mineral complex during digestive transit and enhances cellular delivery through lipid-mediated pathways.

• Water-Dispersible — Soluble in water with a pleasant fruity taste; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

According to the International Osteoporosis Foundation, the recommended daily calcium intake for both women and men aged 19 to 50 years is 1,000 mg, increasing to 1,200 mg from age 51 in women and after 70 in men. For CCM specifically, clinical trials have used 1,000 mg/day of elemental calcium in children and adolescents for bone mineral density support. A common supplemental dose range is 500–600 mg/day of elemental calcium from CCM, which can be taken with or without food. The Tolerable Upper Intake Level (UL) for calcium is 2,000–2,500 mg per day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.