Product Detailed Description

liposomal Calcium D-Pantothenate 80% — High Bioavailability Vitamin B5 Supplement

Product Overview

Liposomal Calcium D-Pantothenate 80% is a premium-grade dietary supplement ingredient delivering calcium D-pantothenate in an advanced liposomal delivery system. Calcium D-pantothenate (CAS 137-08-6), also known as D-calcium pantothenate, vitamin B5 calcium, or calcium (R)-pantothenate, is the calcium salt of the dextrorotatory isomer of pantothenic acid. It is chemically characterized by the molecular formula C₁₈H₃₂CaN₂O₁₀ and a molecular weight of 476.53 g/mol. The compound occurs as a white crystalline powder that is odorless, has a slightly bitter taste, and is slightly hygroscopic. It is readily soluble in water and practically insoluble in ethanol.

Calcium D-pantothenate is the most stable, directly bioavailable form of vitamin B5 used in dietary supplements and food fortification. Pantothenic acid is the amide between pantoic acid and β-alanine and is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Only the D-isomer possesses biological activity, while the L-isomer may antagonize the effects of the D-isomer. The name “pantothenic” is derived from the Greek word pantothen, meaning “from everywhere,” reflecting its widespread presence in foods including whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt.

Why Liposomal Technology?

Conventional vitamin B5 supplementation faces significant pharmacokinetic challenges. The primary absorption mechanism for pantothenic acid and its derivatives is the sodium-dependent multivitamin transporter (SMVT), which is saturable and exhibits dose-dependent absorption kinetics. At higher doses, SMVT becomes saturated, and absorption efficiency declines, limiting systemic bioavailability.

Liposomal encapsulation provides four critical advantages:

1. Bypass of SMVT Saturation — Liposomal encapsulation offers a biomimetic “Trojan horse” delivery mechanism that protects vitamin B5 from the acidic gastric environment. By utilizing a phospholipid bilayer, this technology enables non-saturable absorption pathways such as passive diffusion, endocytosis, and lymphatic uptake, effectively bypassing the competitive limitations of SMVT and the hepatic first-pass effect.

2. Enhanced Bioavailability — Liposomal formulations of calcium D-pantothenate have been shown to increase bioavailability to 94.7% in comparative studies. The phospholipid bilayer shields the active ingredient from gastric degradation and facilitates efficient cellular uptake through lipid-mediated pathways.

3. Enhanced Stability and Controlled Release — Liposomal encapsulation significantly improves the stability of pantothenic acid, particularly at moderately acidic pH and elevated temperatures. The phospholipid layer acts as a protective shell, preventing degradation due to light, oxidation, or pH changes, while enabling a slow release within the body to extend the duration of effectiveness.

4. Enhanced Cellular Uptake and Tissue Delivery — liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism is particularly advantageous for supporting skin barrier repair, tissue regeneration, and metabolic management through enhanced coenzyme A synthesis.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% calcium D-pantothenate in the liposomal formulation, with USP/FCC-grade assay of 98.0%–102.0% on dried basis available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 94.7% bioavailability compared to conventional forms, bypassing SMVT saturation through non-saturable absorption pathways.

• Coenzyme A Precursor — Vitamin B5 is the fundamental precursor for coenzyme A (CoA) biosynthesis, indispensable for the TCA cycle, fatty acid synthesis, and the metabolism of carbohydrates, proteins, and fats.

• Clinically Validated for Wound Healing — A 12-week study (n=120) demonstrated that liposomal calcium D-pantothenate (500 mg/day) reduced wound healing times by 37% compared to placebo (p=0.002) through enhanced fibroblast proliferation.

• Skin Barrier and Moisturization — Supports skin barrier repair, hydration, and natural moisture retention through enhanced CoA synthesis in epithelial cells.

• Cellular Energy Metabolism — Provides bioavailable vitamin B5 for CoA synthesis, supporting mitochondrial energy production and contributing to the reduction of tiredness and fatigue.

• GRAS and FDA Affirmed — Calcium pantothenate is Generally Recognized As Safe (GRAS) by the FDA under 21 CFR 184.1212 for use as a nutrient supplement, with no limitation other than current good manufacturing practice.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for pantothenic acid is 5 mg/day for adults, increasing to 6 mg/day during pregnancy and 7 mg/day during lactation. For supplemental use, commercial calcium pantothenate tablets typically provide 100 mg per tablet, with a typical dosing range of 1–2 tablets daily (100–200 mg/day). For therapeutic applications such as wound healing, clinical studies have used 500 mg/day of liposomal calcium D-pantothenate. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and bypass of SMVT saturation.

Important Safety Information: Calcium D-pantothenate is generally well tolerated. It is a water-soluble vitamin, and excess amounts are excreted in the urine. No tolerable upper intake level (UL) has been established for pantothenic acid due to its low toxicity. Individuals with known hypersensitivity to pantothenic acid or its salts should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.