Product Detailed Description

Liposomal Vitamin B3 Nicotinamide 80% — High Bioavailability Vitamin B3 Supplement

Product Overview

liposomal Vitamin B3 Nicotinamide 80% is a premium-grade dietary supplement ingredient delivering nicotinamide in an advanced liposomal delivery system. Nicotinamide (CAS 98-92-0), also known as niacinamide, nicotinic acid amide, or 3-pyridinecarboxamide, is the water-soluble amide form of vitamin B3 with the molecular formula C₆H₆N₂O and a molecular weight of 122.13 g/mol. It occurs as a white crystalline powder or colorless needles, is odorless or has a slight characteristic odor, and has a melting point of 128–131°C. Nicotinamide is freely soluble in water (1000 g/L) and ethanol, and is practically insoluble in ether and benzene.

Nicotinamide is one of the two primary forms of vitamin B3 and is the preferred form for applications requiring high-dose vitamin B3 supplementation without the flushing reaction associated with nicotinic acid. Nicotinamide is a critical precursor to nicotinamide adenine dinucleotide (NAD+) and its phosphate form (NADP+), which are essential coenzymes in cellular Energy Metabolism, DNA repair, and redox homeostasis. Over 400 enzymes require NAD+ to catalyze reactions within the body, including those involved in glycolysis, the Krebs cycle, and the electron transport chain. Nicotinamide is widely distributed in nature, with rich dietary sources including meat (especially liver), fish, poultry, dairy products, eggs, peanuts, and whole grains.

Why Liposomal Technology?

Conventional nicotinamide presents significant formulation and bioavailability challenges. The compound is highly water-soluble, which limits its passive diffusion across biological membranes and its penetration through the stratum corneum of the skin. Following oral administration, nicotinamide is rapidly absorbed and distributed throughout the body, but its hydrophilic nature causes rapid clearance and limited cellular retention.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Encapsulation Efficiency and Stability — Liposomal encapsulation of nicotinamide achieves 80% ± 5% encapsulation efficiency, with stability studies over three weeks at 4°C showing minimal changes in liposomal characteristics, indicating good stability. The phospholipid bilayer surrounds the nicotinamide molecule, forming a protective shell that shields it from premature degradation during storage and gastrointestinal transit.

2. Enhanced Skin Permeation and Accumulation — Liposomal formulations significantly improve skin permeation and accumulation of nicotinamide. Skin permeation studies of liposomes containing nicotinamide for cosmeceutical application indicated that the liposomal formulation could increase skin permeation and accumulation of nicotinamide in the skin. The incorporation of fatty alcohols into nanoliposomes enables ceramide and niacinamide to penetrate deeper into the stratum corneum layer, resulting in enhanced strengthening of the skin barrier and improved skin lightening effects.

3. Spatial Isolation and Controlled Release — Liposomal encapsulation provides spatial isolation of nicotinamide through physical encapsulation within the liposomal bilayer, achieving controlled release during use. This significantly improves storage stability, retaining over 85% of each active ingredient. The controlled-release profile supports prolonged biological activity rather than a sharp peak followed by rapid clearance.

4. Enhanced Cellular Uptake and Bioavailability — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This complements the aqueous transport pathways utilized by free nicotinamide, supporting enhanced systemic absorption and cellular delivery of the active vitamin.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% nicotinamide in the liposomal formulation, with USP/EP/ChP-grade assay of 99.0%–101.0% on dried basis available.

• Liposomal Enhancement — Liposomal encapsulation achieves 80% ± 5% encapsulation efficiency with good stability over three weeks at 4°C, and significantly enhances skin permeation and accumulation.

• NAD+ Precursor — Nicotinamide is a direct precursor to NAD+, a coenzyme essential for over 400 enzymatic reactions including glycolysis, the Krebs cycle, and DNA repair.

• Clinically Validated for Skin Cancer Prevention — A randomized controlled trial (ONTRAC) demonstrated that 500 mg of nicotinamide twice daily significantly reduced the rate of new non-melanoma skin cancers by 23% after 12 months.

• Skin Barrier and Pigmentation Support — Nicotinamide improves skin barrier function, reduces hyperpigmentation, and supports skin lightening through inhibition of melanosome transfer and improvement of skin barrier integrity.

• No Flushing — Unlike nicotinic acid, nicotinamide does not cause the characteristic flushing reaction, making it suitable for high-dose supplementation without vasodilation side effects.

• DNA Repair and Cellular Health — NAD+ is essential for DNA repair through PARP-mediated mechanisms, and nicotinamide supports healthy DNA repair and cellular energy metabolism.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for niacin is 14–16 mg NE/day for adults. Oral nicotinamide supplements have been studied at daily doses ranging from 25 mg to 6,000 mg (6 grams) for up to 5 years. For treating pellagra (a severe vitamin B3 deficiency), 300 mg daily of nicotinamide is usually sufficient. For skin cancer prevention, the ONTRAC trial used 500 mg of nicotinamide twice daily (1,000 mg/day) for 12 months. The tolerable upper intake level (UL) for nicotinamide is 5 mg/kg body weight, corresponding to approximately 350 mg/day for a 70 kg adult. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and skin permeation.

Important Safety Information: Nicotinamide is generally well tolerated at commonly used doses. Unlike nicotinic acid, nicotinamide does not cause flushing. High-dose nicotinamide (≥3 g/day) has been associated with hepatotoxicity in some studies and should only be used under medical supervision. Individuals with active liver disease should not use high-dose nicotinamide. Pregnant or lactating women and children should consult a healthcare professional before use. Nicotinamide may interact with certain medications, including anticoagulants and diabetes medications.