Product Detailed Description

liposomal P5P (Pyridoxal 5'-Phosphate) 70% — High Bioavailability Active Vitamin B6 Supplement

Product Overview

Liposomal P5P 70% is a premium-grade dietary supplement ingredient delivering pyridoxal 5'-phosphate in an advanced liposomal delivery system. P5P (CAS 54-47-7 for the free acid; CAS 41468-25-1 for the monohydrate), also known as pyridoxal phosphate, PLP, phosphopyridoxal, or codecarboxylase, is the biologically active form of vitamin B6. It is chemically characterized by the molecular formula C₈H₁₀NO₆P and a molecular weight of 247.14 g/mol, and occurs as a pale yellow to white crystalline powder that is sensitive to light, air, and moisture.

P5P is the active coenzyme form of vitamin B6 and is directly utilized by more than 100 enzymes without requiring hepatic conversion. It plays a critical role in amino acid metabolism, neurotransmitter synthesis, glycogenolysis, and the regulation of homocysteine. The aldehyde group of P5P is highly reactive, forming a Schiff base with the ε-amino group of a specific lysine residue in the active site of P5P-dependent enzymes. P5P is the only form of vitamin B6 that can be directly utilized by the body, making it particularly valuable for individuals with impaired hepatic conversion capacity.

Why Liposomal Technology?

Conventional P5P presents significant formulation and stability challenges. P5P is notoriously unstable in aqueous solutions, being susceptible to degradation by light, pH variations, and interactions with other molecules. The primary photodegradation product has been identified as 4-pyridoxic acid 5'-phosphate (PAP), and studies have shown that PLP liquids prepared from dietary supplements are stable at room temperature (protected from light) after 24 hours but unstable after 4 hours when exposed to light. Additionally, the reactive aldehyde group of P5P can form Schiff bases with amino acids or other primary amines, leading to a decrease in the concentration of free, active P5P.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability and Photoprotection — The phospholipid bilayer shields P5P from light-induced degradation, pH-dependent breakdown, and Schiff base formation. Liposomal encapsulation provides a protective microenvironment that maintains the integrity of P5P during storage and gastrointestinal transit, significantly extending its stability profile.

2. Direct Cellular Delivery of the Active Form — liposomes fuse directly with cell membranes, facilitating efficient delivery of P5P into cells where it can immediately function as a coenzyme. This bypasses the need for hepatic conversion that pyridoxine hydrochloride requires, making P5P directly bioavailable at the cellular level.

3. Enhanced Bioavailability — Liposomal delivery systems achieve 3 to 4 times better absorption compared to conventional forms. The phospholipid bilayer protects P5P from gastric degradation and first-pass metabolism, ensuring more of the active coenzyme reaches systemic circulation.

4. Sustained Release for Prolonged Enzymatic Activity — Liposomal delivery provides a controlled-release profile that maintains steady plasma levels of P5P, supporting prolonged enzymatic cofactor activity rather than a sharp peak followed by rapid renal excretion.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% P5P in the liposomal formulation, with ≥98.0% (HPLC) assay available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 3 to 4 times better absorption compared to conventional forms and protects P5P from light-induced degradation and Schiff base formation.

• Directly Active Form — P5P is the biologically active coenzyme form of vitamin B6 that requires no hepatic conversion, making it directly available for enzymatic reactions.

• Clinically Validated for PNPO Deficiency — A systematic review demonstrated that clinical seizure responsiveness following P5P therapy was observed in 77.6% of patients with PNPO deficiency, and P5P treatment significantly improved survival (p < 0.001).

• Neurotransmitter Synthesis — P5P is an essential cofactor for the synthesis of serotonin, dopamine, GABA, and norepinephrine, supporting mood regulation, cognitive function, and nervous system health.

• Homocysteine Regulation — P5P is a cofactor for cystathionine β-synthase and cystathionine γ-lyase in the transsulfuration pathway, supporting healthy homocysteine metabolism.

• Cardiovascular Support — P5P supports a healthy cardiovascular system through its role in homocysteine regulation and neurotransmitter synthesis.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Commercial P5P supplements typically provide 25–100 mg of pyridoxal 5'-phosphate per serving, with a common daily dose of 50 mg. The Tolerable Upper Intake Level (UL) for vitamin B6 is 100 mg/day for adults. In China, the tolerable upper intake level for vitamin B6 is 60 mg/day. For supplemental use, many P5P products provide 25–50 mg per capsule or tablet, with a recommended intake of 1–2 servings daily with food. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and protection from degradation.

Important Safety Information: P5P is generally well tolerated at recommended doses. Prolonged intake of high doses (>200 mg/day of vitamin B6) has been associated with peripheral sensory neuropathy. Individuals with known hypersensitivity to pyridoxine or its derivatives should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. P5P may interact with certain medications, including levodopa, phenytoin, and penicillamine.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.